HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	29991678, 11297560
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005654 - nucleoplasm GO:0019221 - cytokine-mediated signaling pathway GO:0030225 - macrophage differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 972
+	Mm
		193337 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		CSF1R_MOUSE (1-972): 0: 726: 74.57
+	Hs
		181778 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		256847 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		499278 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		499291 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		146585 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		147481 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		411567 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		KIT_HUMAN (16-956): 0: 609: 37.13
+	Hs
		181810 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Hs
		452495 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31
+	Hs
		452375 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31
+	Hs
		146603 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Hs
		147491 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Hs
		411619 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35
+	Mm
		193364 SOCS2_MOUSE (37-211): 1.07e-42: 144: 28.57		FLT3_MOUSE (13-953): 2.07e-173: 533: 31.11
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (13-300): 6.13e-55: 207: 15.92
+	Hs
		147484 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		FGFR3_HUMAN (13-300): 6.13e-55: 207: 15.92
+	Mm
		193336 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		KIT_MOUSE (9-293): 5.75e-23: 107: 13.08
+	Hs
		181803 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		UFO_HUMAN (1-308): 2.37e-23: 108: 14.49
+	Hs
		411613 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		UFO_HUMAN (1-308): 2.37e-23: 108: 14.49