Protein: TXD12
Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19)

Gene: TXD12, TXNDC12
Organism: Homo sapiens
Interactions: 81
UniProt ID: O95881

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0015035 - protein-disulfide reductase activity
GO:0019153 - protein-disulfide reductase (glutathione) activity
GO:1902236 - negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

350633

UBQL1
Ubiquilin-1

2

6

High-throughput

0.628

High

350619

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

3

7

High-throughput

0.616

High

350585

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

2

1

High-throughput

0.606

High

350638

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

2

High-throughput

0.606

High

350580

TBG1
Tubulin gamma-1 chain

2

7

High-throughput

0.574

High

350604

MZT2B
Mitotic-spindle organizing protein 2B

2

1

High-throughput

0.574

High

350605

MZT2A
Mitotic-spindle organizing protein 2A

2

1

High-throughput

0.574

High

350618

GCP3
Gamma-tubulin complex component 3

2

4

High-throughput

0.574

High

350622

GCP6
Gamma-tubulin complex component 6

2

4

High-throughput

0.574

High

350623

GCP5
Gamma-tubulin complex component 5

2

4

High-throughput

0.574

High

350625

GCP2
Gamma-tubulin complex component 2

2

4

High-throughput

0.574

High

350631

GCP4
Gamma-tubulin complex component 4

2

4

High-throughput

0.574

High

350637

NDK7
Nucleoside diphosphate kinase homolog 7

2

1

High-throughput

0.574

High

350616

REQU
Zinc finger protein ubi-d4

2

3

High-throughput

0.553

High

350632

UBQL2
Ubiquilin-2

2

6

High-throughput

0.553

High

350592

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

226649

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

7

High-throughput

0.523

High

350572

HCK
Tyrosine-protein kinase HCK

2

1

High-throughput

0.521

High

350582

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.521

High

350596

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.521

High

350610

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

3

High-throughput

0.521

High

350613

SH2D3
SH2 domain-containing protein 3C

2

4

High-throughput

0.521

High

350617

ARHG1
Rho guanine nucleotide exchange factor 1

2

2

High-throughput

0.521

High

350611

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

350578

H2AX
Histone H2AX

1

2

High-throughput

0.489

High

350639

SAR1B
Small COPII coat GTPase SAR1B

1

8

High-throughput

0.489

High

217675

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

350576

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

319266

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

350620

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

142778

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.437

High

350567

ESR1
Estrogen receptor

1

1

High-throughput

0.437

High

350569

NPM
Nucleophosmin

1

1

High-throughput

0.437

High

350570

CATL1
Procathepsin L

1

1

High-throughput

0.437

High

350571

CATB
Cathepsin B

1

2

High-throughput

0.437

High

350573

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.437

High

350574

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.437

High

350581

CATS
Cathepsin S

1

1

High-throughput

0.437

High

350583

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.437

High

350589

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.437

High

350590

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

350593

PWP1
Periodic tryptophan protein 1 homolog

1

2

High-throughput

0.437

High

350594

CUL3
Cullin-3

1

1

High-throughput

0.437

High

350595

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.437

High

350597

RBBP7
Histone-binding protein RBBP7

1

1

High-throughput

0.437

High

350599

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.437

High

350600

EPHAA
Ephrin type-A receptor 10

1

1

High-throughput

0.437

High

350601

DCA10
DDB1- and CUL4-associated factor 10

1

2

High-throughput

0.437

High

350603

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

350606

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

350608

WDR53
WD repeat-containing protein 53

1

2

High-throughput

0.437

High

350612

WDTC1
WD and tetratricopeptide repeats protein 1

1

5

High-throughput

0.437

High

350614

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.437

High

350626

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

350627

DCA13
DDB1- and CUL4-associated factor 13

1

2

High-throughput

0.437

High

350630

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

350568

PRIO
Major prion protein

1

0

High-throughput

0.426

High

350575

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.407

High

329044

KLHL2
Kelch-like protein 2

3

0

High-throughput

0.348

High

350624

TM2D3
TM2 domain-containing protein 3

3

0

High-throughput

0.345

High

350577

BRAF
Serine/threonine-protein kinase B-raf

2

0

High-throughput

0.298

High

350621

YTDC1
YTH domain-containing protein 1

1

0

High-throughput

0.269

Low

350634

GBRT
Gamma-aminobutyric acid receptor subunit theta

1

0

High-throughput

0.269

Low

105040

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

292997

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

350566

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

350579

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

350584

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

350586

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

350588

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

350591

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.249

Low

350598

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.249

Low

350602

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

350607

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

350609

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.249

Low

350615

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

350628

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

350635

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

350636

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

350587

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.232

Low

350629

FBLN5
Fibulin-5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025