HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31101761
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, SH2~SOCS_box
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 536
+	Hs
		146668 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		181770 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		181765 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FYN_HUMAN (1-536): 0: 598: 68.39
+	Hs
		146582 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		411552 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		412098 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		FYN_HUMAN (1-536): 0: 598: 68.39
+	Hs
		411545 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		FYN_HUMAN (1-536): 0: 598: 68.39
+	Hs
		181764 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LCK_HUMAN (75-534): 0: 552: 58.48
+	Hs
		181771 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LYN_HUMAN (1-531): 0: 532: 52.44
+	Hs
		146580 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		LCK_HUMAN (75-534): 0: 552: 58.48
+	Hs
		411544 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		LCK_HUMAN (75-534): 0: 552: 58.48
+	Hs
		181824 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		BLK_HUMAN (45-531): 1.62e-179: 516: 57.58
+	Hs
		181753 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00
+	Hs
		411553 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		LYN_HUMAN (1-531): 0: 532: 52.44
+	Dm
		337688 Q8INY1_DROME (26-210): 6.61e-43: 154: 23.00		SRC64_DROME (56-535): 7.2e-178: 514: 51.43
+	Dm
		337701 Q9VJA1_DROME (26-210): 3.45e-43: 154: 23.00		SRC64_DROME (56-535): 7.2e-178: 514: 51.43
+	Mm
		337630 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		ABL1_MOUSE (47-536): 4.29e-169: 509: 40.00
+	Hs
		181852 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ITK_HUMAN (54-525): 1.53e-160: 472: 34.23
+	Hs
		181816 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TEC_HUMAN (83-528): 6.43e-155: 458: 37.36
+	Hs
		147492 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		TXK_HUMAN (13-526): 7.51e-161: 469: 34.55