Protein: TYRO3
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)

Gene: TYRO3
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q06418

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001764 - neuron migration
GO:0001779 - natural killer cell differentiation
GO:0004713 - protein tyrosine kinase activity
GO:0004714 - transmembrane receptor protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987571

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.858

High

1055047

GAS6
Growth arrest-specific protein 6

2

20

Small-scale

0.812

High

461393

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.767

High

468294

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.767

High

699708

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.713

High

1055041

TYRO3
Tyrosine-protein kinase receptor TYRO3

2

18

Small-scale

0.712

High

291779

STK16
Serine/threonine-protein kinase 16

1

16

High-throughput

0.691

High

1052791

ACHB3
Neuronal acetylcholine receptor subunit beta-3

3

1

High-throughput

0.667

High

1055075

LPAR1
Lysophosphatidic acid receptor 1

3

2

High-throughput

0.667

High

362257

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.646

High

409361

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

18

High-throughput

0.646

High

421978

A4
Amyloid-beta precursor protein

1

20

High-throughput

0.646

High

472047

MET
Hepatocyte growth factor receptor

1

19

High-throughput

0.646

High

564820

NCAM1
Neural cell adhesion molecule 1

1

20

High-throughput

0.646

High

580762

PVR
Poliovirus receptor

1

20

High-throughput

0.646

High

774310

BASI
Basigin

1

20

High-throughput

0.646

High

787386

TGFR1
TGF-beta receptor type-1

1

14

High-throughput

0.646

High

1055045

PTK7
Inactive tyrosine-protein kinase 7

1

19

High-throughput

0.646

High

1055059

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

20

High-throughput

0.646

High

1055078

LRC59
Leucine-rich repeat-containing protein 59

1

20

High-throughput

0.646

High

1055087

TBB6
Tubulin beta-6 chain

1

12

High-throughput

0.646

High

1055093

RAB1B
Ras-related protein Rab-1B

1

12

High-throughput

0.646

High

1055052

CC50B
Cell cycle control protein 50B

2

6

High-throughput

0.628

High

410794

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

720199

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.621

High

557250

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

710194

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.618

High

840952

ABL2
Tyrosine-protein kinase ABL2

1

20

High-throughput

0.618

High

1055043

ARHG5
Rho guanine nucleotide exchange factor 5

1

20

High-throughput

0.618

High

1055084

COCA1

1

17

High-throughput

0.618

High

1055110

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.618

High

1055113

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

20

High-throughput

0.618

High

685839

KRA59
Keratin-associated protein 5-9

3

16

High-throughput

0.613

High

1055096

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

1055051

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.578

High

1055085

MDFI
MyoD family inhibitor

1

1

High-throughput

0.573

High

1055118

NEMO
NF-kappa-B essential modulator

1

15

High-throughput

0.561

High

1055070

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.555

High

74116

VWC2L
von Willebrand factor C domain-containing protein 2-like

2

6

High-throughput

0.553

High

1055089

KRA92
Keratin-associated protein 9-2

2

6

High-throughput

0.553

High

1055091

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

12

High-throughput

0.541

High

1055049

TNIP1
TNFAIP3-interacting protein 1

2

20

High-throughput

0.539

High

698601

CALX
Calnexin

1

20

High-throughput

0.536

High

1055071

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

5

High-throughput

0.536

High

1055077

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

1055116

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.536

High

950236

KR107
Keratin-associated protein 10-7

1

15

High-throughput

0.523

High

950459

KR108
Keratin-associated protein 10-8

1

15

High-throughput

0.523

High

950749

KR109
Keratin-associated protein 10-9

1

18

High-throughput

0.523

High

1055060

K1C40
Keratin, type I cytoskeletal 40

1

8

High-throughput

0.523

High

1055090

KRA42
Keratin-associated protein 4-2

1

6

High-throughput

0.523

High

1055115

KLK4
Kallikrein-4

1

20

High-throughput

0.523

High

1055069

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

1

0

High-throughput

0.513

High

124317

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.500

High

170735

CLGN
Calmegin

1

20

High-throughput

0.500

High

172728

XPO1
Exportin-1

1

16

High-throughput

0.500

High

299975

CBPD
Carboxypeptidase D

1

13

High-throughput

0.500

High

321224

ERLN2
Erlin-2

1

7

High-throughput

0.500

High

390548

TFR1
Transferrin receptor protein 1

1

6

High-throughput

0.500

High

417393

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

6

High-throughput

0.500

High

418083

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

6

High-throughput

0.500

High

420506

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.500

High

424861

ADT2
ADP/ATP translocase 2

1

6

High-throughput

0.500

High

467466

4F2
Amino acid transporter heavy chain SLC3A2

1

6

High-throughput

0.500

High

533647

CLUS
Clusterin

1

6

High-throughput

0.500

High

534969

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.500

High

540417

LAMP1
Lysosome-associated membrane glycoprotein 1

1

7

High-throughput

0.500

High

548488

MPRI
Cation-independent mannose-6-phosphate receptor

1

13

High-throughput

0.500

High

552209

ADT3
ADP/ATP translocase 3

1

6

High-throughput

0.500

High

566645

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.500

High

598069

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.500

High

618246

CADH2
Cadherin-2

1

20

High-throughput

0.500

High

627320

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

9

High-throughput

0.500

High

633845

MPRD
Cation-dependent mannose-6-phosphate receptor

1

2

High-throughput

0.500

High

727772

DNJA1
DnaJ homolog subfamily A member 1

1

20

High-throughput

0.500

High

764316

CTNA1
Catenin alpha-1

1

14

High-throughput

0.500

High

764690

CTNB1
Catenin beta-1

1

20

High-throughput

0.500

High

813070

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

5

High-throughput

0.500

High

844759

EAA1
Excitatory amino acid transporter 1

1

16

High-throughput

0.500

High

847508

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.500

High

863461

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

5

High-throughput

0.500

High

869849

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

2

High-throughput

0.500

High

894700

EMD
Emerin

1

14

High-throughput

0.500

High

931348

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

2

High-throughput

0.500

High

963054

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

7

High-throughput

0.500

High

1008105

PRKDC
DNA-dependent protein kinase catalytic subunit

1

19

High-throughput

0.500

High

1024336

S25A3
Solute carrier family 25 member 3

1

9

High-throughput

0.500

High

1032456

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

13

High-throughput

0.500

High

1055048

DSC3
Desmocollin-3

1

20

High-throughput

0.500

High

1055050

OZF
Zinc finger protein OZF

1

6

High-throughput

0.500

High

1055055

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

7

High-throughput

0.500

High

1055056

NU188
Nucleoporin NUP188

1

2

High-throughput

0.500

High

1055057

ATD3B
ATPase family AAA domain-containing protein 3B

1

10

High-throughput

0.500

High

1055058

SE1L2
Protein sel-1 homolog 2

1

9

High-throughput

0.500

High

1055062

CNNM4
Metal transporter CNNM4

1

6

High-throughput

0.500

High

1055065

QSOX2
Sulfhydryl oxidase 2

1

20

High-throughput

0.500

High

1055068

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.500

High

1055072

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

2

High-throughput

0.500

High

1055074

S39A7
Zinc transporter SLC39A7

1

9

High-throughput

0.500

High

1055086

NTPCR
Cancer-related nucleoside-triphosphatase

1

12

High-throughput

0.500

High

1055092

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

2

High-throughput

0.500

High

1055094

TMX1
Thioredoxin-related transmembrane protein 1

1

20

High-throughput

0.500

High

1055101

T106B
Transmembrane protein 106B

1

5

High-throughput

0.500

High

1055103

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

1

High-throughput

0.500

High

1055105

TECR
Very-long-chain enoyl-CoA reductase

1

4

High-throughput

0.500

High

1055106

HACD3
Very-long-chain

1

8

High-throughput

0.500

High

1055108

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.500

High

1055109

DDX20
Probable ATP-dependent RNA helicase DDX20

1

5

High-throughput

0.500

High

1055111

ITM2B
Integral membrane protein 2B

1

6

High-throughput

0.500

High

1055114

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.500

High

158565

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

12

High-throughput

0.494

High

387412

APOE
Apolipoprotein E

1

5

High-throughput

0.481

High

876318

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.479

High

1055067

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.479

High

1055082

NEUR1
Sialidase-1

1

0

High-throughput

0.479

High

1055117

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.479

High

281035

TACC1
Transforming acidic coiled-coil-containing protein 1

1

20

High-throughput

0.479

High

469066

SRPRA
Signal recognition particle receptor subunit alpha

1

11

High-throughput

0.479

High

475956

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

10

High-throughput

0.479

High

1055042

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

1055046

STIM1
Stromal interaction molecule 1

1

17

High-throughput

0.479

High

1055064

NFXL1
NF-X1-type zinc finger protein NFXL1

1

20

High-throughput

0.479

High

1055076

US6NL
USP6 N-terminal-like protein

1

14

High-throughput

0.479

High

1055079

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1055081

CLCC1
Chloride channel CLIC-like protein 1

1

9

High-throughput

0.479

High

1055088

RFIP5
Rab11 family-interacting protein 5

1

10

High-throughput

0.479

High

1055097

GORS2
Golgi reassembly-stacking protein 2

1

13

High-throughput

0.479

High

1055099

JPH1
Junctophilin-1

1

10

High-throughput

0.479

High

1055107

STIM2
Stromal interaction molecule 2

1

17

High-throughput

0.479

High

697412

DCK
Deoxycytidine kinase

1

0

High-throughput

0.458

High

1055080

RANB9
Ran-binding protein 9

1

8

Small-scale

0.457

High

1055100

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

137706

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

9

High-throughput

0.457

High

215712

COCH
Cochlin

1

4

High-throughput

0.457

High

220901

XPOT
Exportin-T

1

14

High-throughput

0.457

High

317831

LTN1
E3 ubiquitin-protein ligase listerin

1

2

High-throughput

0.457

High

441477

AGAL
Alpha-galactosidase A

1

5

High-throughput

0.457

High

784592

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

2

High-throughput

0.457

High

1055044

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.457

High

1055054

GXLT1
Glucoside xylosyltransferase 1

1

3

High-throughput

0.457

High

1055061

SFXN4
Sideroflexin-4

1

1

High-throughput

0.457

High

1055066

MON2
Protein MON2 homolog

1

9

High-throughput

0.457

High

1055073

FACR1
Fatty acyl-CoA reductase 1

1

3

High-throughput

0.457

High

1055095

RNF41
E3 ubiquitin-protein ligase NRDP1

1

13

High-throughput

0.457

High

1055098

TM9S3
Transmembrane 9 superfamily member 3

1

3

High-throughput

0.457

High

1055102

FANCI
Fanconi anemia group I protein

1

7

High-throughput

0.457

High

254984

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

11

High-throughput

0.445

High

388400

B3AT
Band 3 anion transport protein

1

15

High-throughput

0.445

High

369666

A2MG
Alpha-2-macroglobulin

1

3

High-throughput

0.439

High

949859

KR103
Keratin-associated protein 10-3

1

15

High-throughput

0.439

High

1055063

F171B
Protein FAM171B

1

18

High-throughput

0.437

High

1055083

CDCA3
Cell division cycle-associated protein 3

1

10

High-throughput

0.437

High

1055112

CHTOP
Chromatin target of PRMT1 protein

1

5

High-throughput

0.437

High

903680

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.261

Low

1055053

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1055104

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025