HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: VAV2 (P52735)
Guanine nucleotide exchange factor VAV2 (VAV-2)
Gene: VAV2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29991678, 10022833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~SH2, SH2~SH2, SH2~SH3_2, SH2~SOCS_box
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 878
+	Hs
		412098 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		VAV2_HUMAN (1-878): 0: 658: 100.00
+	Hs
		181787 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		VAV_HUMAN (1-875): 8.4e-175: 529: 47.20
+	Hs
		411580 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		VAV_HUMAN (1-875): 8.4e-175: 529: 47.20
+	Hs
		411981 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		VAV_HUMAN (1-875): 8.4e-175: 529: 47.20
+	Hs
		411673 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		FGD1_HUMAN (103-618): 4.37e-71: 255: 16.46
+	Hs
		412357 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		ECT2_HUMAN (99-622): 1.95e-67: 243: 13.85
+	Hs
		224698 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		KALRN_HUMAN (164-650): 4.79e-62: 231: 15.81
+	Hs
		224699 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		KALRN_HUMAN (164-650): 4.79e-62: 231: 15.81
+	Hs
		279830 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		TRIO_HUMAN (187-658): 6.64e-51: 197: 13.25
+	Hs
		146674 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62
+	Hs
		181839 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62
+	Hs
		209055 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		ARHG6_HUMAN (742-874): 2.14e-14: 79.5: 24.81
+	Hs
		209051 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		ARHG7_HUMAN (684-877): 7.11e-14: 78: 18.00
+	Hs
		924732 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62
+	Hs
		924938 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62
+	Hs
		557687 NCK1_HUMAN (17-175): 2.39e-36: 132: 21.25		ARHG7_HUMAN (684-877): 7.11e-14: 78: 18.00
+	Hs
		855781 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62
+	Mm
		1141129 VAV2_MOUSE (1-181): 1.07e-38: 143: 17.11		GRB2_MOUSE (821-873): 5.79e-11: 65.2: 39.62
+	Mm
		763393 FYN_MOUSE (64-194): 1.54e-37: 138: 18.44		GRB2_MOUSE (821-873): 5.79e-11: 65.2: 39.62
+	Hs
		557655 NCK1_HUMAN (17-175): 2.39e-36: 132: 21.25		GRB2_HUMAN (821-873): 5.47e-11: 65.2: 39.62