Protein: INSR
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]

Gene: INSR
Organism: Mus musculus
Interactions: 24
UniProt ID: P15208

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0002092 - positive regulation of receptor internalization
GO:0003007 - heart morphogenesis
GO:0004713 - protein tyrosine kinase activity
GO:0005009 - insulin receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

581968

SH2B2
SH2B adapter protein 2

2

20

Small-scale

0.754

High

581963

GRB10
Growth factor receptor-bound protein 10

2

20

Small-scale

0.703

High

431318

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.691

High

581952

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.691

High

205419

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.618

High

312044

SORL
Sortilin-related receptor

1

20

Small-scale

0.618

High

581951

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

581954

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.618

High

581962

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

14

Small-scale

0.618

High

581964

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.618

High

581966

SNX9
Sorting nexin-9

1

20

Small-scale

0.618

High

581953

RAB24
Ras-related protein Rab-24

1

20

High-throughput

0.575

High

581965

RAB34
Ras-related protein Rab-34

1

20

High-throughput

0.575

High

581955

CAV1
Caveolin-1

2

9

Small-scale

0.571

High

581958

DOK1
Docking protein 1

1

20

Small-scale

0.555

High

205454

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.553

High

581967

ARRB2
Beta-arrestin-2

1

4

Small-scale

0.536

High

581969

DOK3
Docking protein 3

1

20

Small-scale

0.481

High

148497

FLOT1
Flotillin-1

1

15

Small-scale

0.479

High

581956

CAV3
Caveolin-3

1

9

Small-scale

0.479

High

581959

PLAK
Junction plakoglobin

1

20

Small-scale

0.479

High

581961

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

581960

TRI72
Tripartite motif-containing protein 72

1

4

Small-scale

0.457

High

581957

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

1

Small-scale

0.445

High


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Last updated: 11Aug2025