HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29991678
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 780
+	Hs
		146692 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193357 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		256856 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1265273 SOCS4_MOUSE (3-210): 2.25e-46: 160: 18.98		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		222648 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1263831 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		146642 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		147544 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		1274062 CISH_HUMAN (22-211): 6.28e-41: 141: 26.45		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193366 SOCS2_MOUSE (37-211): 1.07e-42: 144: 28.57		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1143676 CISH_MOUSE (22-211): 1.94e-41: 142: 26.56		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1322060 SOCS6_MOUSE (66-209): 7.1e-39: 141: 26.06		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		193394 SOCS3_MOUSE (39-207): 3.5e-41: 141: 27.60		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1042817 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		411713 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		146625 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		855795 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		147421 SOCS3_HUMAN (39-207): 3.53e-40: 138: 27.73		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		181856 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Hs
		1041477 CISH_HUMAN (22-211): 6.28e-41: 141: 26.45		CUL2_HUMAN (6-780): 0: 699: 26.36