Protein: SMAD3
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)

Gene: SMAD3
Organism: Homo sapiens
Interactions: 396
UniProt ID: P84022

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1014496

SMAD4
Mothers against decapentaplegic homolog 4

66

19

Small-scale

0.997

High

555377

SKI
Ski oncogene

16

16

Small-scale

0.987

High

336092

ZFYV9
Zinc finger FYVE domain-containing protein 9

10

12

Small-scale

0.978

High

1014524

SMAD2
Mothers against decapentaplegic homolog 2

12

20

Small-scale

0.977

High

555467

SKIL
Ski-like protein

8

16

Small-scale

0.964

High

1014471

SMAD3
Mothers against decapentaplegic homolog 3

5

19

Small-scale

0.918

High

181876

SMAD9
Mothers against decapentaplegic homolog 9

3

19

High-throughput

0.861

High

1014525

SMAD1
Mothers against decapentaplegic homolog 1

2

19

Small-scale

0.783

High

1014490

NFIA
Nuclear factor 1 A-type

2

7

Small-scale

0.768

High

1014486

EP300
Histone acetyltransferase p300

19

20

Small-scale

0.765

High

1014620

SMUF2
E3 ubiquitin-protein ligase SMURF2

13

20

Small-scale

0.761

High

1014567

CBP
CREB-binding protein

10

17

Small-scale

0.754

High

1014611

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

7

20

Small-scale

0.750

High

1014661

TRI33
E3 ubiquitin-protein ligase TRIM33

7

7

Small-scale

0.736

High

861565

NEDD4
E3 ubiquitin-protein ligase NEDD4

6

20

Small-scale

0.734

High

1014669

MAN1
Inner nuclear membrane protein Man1

6

14

Small-scale

0.733

High

464906

SP1
Transcription factor Sp1

6

6

Small-scale

0.731

High

131948

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

5

20

Small-scale

0.729

High

288080

FOXH1
Forkhead box protein H1

5

17

Small-scale

0.719

High

429728

JUN
Transcription factor Jun

5

10

Small-scale

0.718

High

787379

TGFR1
TGF-beta receptor type-1

5

20

Small-scale

0.714

High

177670

SMAD7
Mothers against decapentaplegic homolog 7

1

18

Small-scale

0.713

High

1014528

HIF1A
Hypoxia-inducible factor 1-alpha

4

8

Small-scale

0.707

High

1014513

CASL
Enhancer of filamentation 1

4

5

Small-scale

0.703

High

764656

CTNB1
Catenin beta-1

5

5

Small-scale

0.702

High

1014539

RN111
E3 ubiquitin-protein ligase Arkadia

5

9

Small-scale

0.702

High

1014588

ERBIN
Erbin

4

10

Small-scale

0.702

High

1014498

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

4

1

Small-scale

0.701

High

1014582

NED4L
E3 ubiquitin-protein ligase NEDD4-like

4

20

Small-scale

0.698

High

1014675

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

4

12

Small-scale

0.696

High

519945

ANDR
Androgen receptor

3

14

Small-scale

0.690

High

1014624

SMUF1
E3 ubiquitin-protein ligase SMURF1

4

20

Small-scale

0.683

High

1014478

MECOM
Histone-lysine N-methyltransferase MECOM

3

15

Small-scale

0.683

High

1014484

TLE5
TLE family member 5

3

1

High-throughput

0.683

High

1014554

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

3

3

High-throughput

0.683

High

1014570

KAT2B
Histone acetyltransferase KAT2B

4

13

Small-scale

0.680

High

877087

KC1D
Casein kinase I isoform delta

3

5

Small-scale

0.675

High

1014575

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

7

Small-scale

0.672

High

180988

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

1

High-throughput

0.667

High

1014595

SMAD5
Mothers against decapentaplegic homolog 5

1

19

Small-scale

0.665

High

1014507

RUNX2
Runt-related transcription factor 2

3

16

Small-scale

0.664

High

1014612

GO45
Golgin-45

3

0

High-throughput

0.658

High

1014520

TGIF1
Homeobox protein TGIF1

3

11

Small-scale

0.656

High

893815

MEOX2
Homeobox protein MOX-2

2

6

High-throughput

0.654

High

1014549

PHC2
Polyhomeotic-like protein 2

2

2

High-throughput

0.654

High

1014499

HDAC1
Histone deacetylase 1

3

12

Small-scale

0.647

High

403982

GCR
Glucocorticoid receptor

2

14

Small-scale

0.646

High

1014650

LEF1
Lymphoid enhancer-binding factor 1

2

20

Small-scale

0.646

High

219718

FOXO3
Forkhead box protein O3

2

19

Small-scale

0.641

High

1014505

RUNX3
Runt-related transcription factor 3

3

16

Small-scale

0.640

High

1014500

SNW1
SNW domain-containing protein 1

2

2

Small-scale

0.639

High

1014573

IRF7
Interferon regulatory factor 7

2

4

Small-scale

0.639

High

1014609

LACRT
Extracellular glycoprotein lacritin

3

0

High-throughput

0.638

High

1014497

SQSTM
Sequestosome-1

2

3

Small-scale

0.631

High

1014552

PIAS4
E3 SUMO-protein ligase PIAS4

2

16

Small-scale

0.631

High

1014659

CHIP
E3 ubiquitin-protein ligase CHIP

2

5

Small-scale

0.629

High

212719

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

2

12

Small-scale

0.624

High

617147

ATF3
Cyclic AMP-dependent transcription factor ATF-3

2

17

Small-scale

0.624

High

891447

GSK3B
Glycogen synthase kinase-3 beta

2

8

Small-scale

0.624

High

1014640

WWOX
WW domain-containing oxidoreductase

2

1

Small-scale

0.624

High

473915

NFIC
Nuclear factor 1 C-type

1

7

Small-scale

0.618

High

675459

TYY1
Transcriptional repressor protein YY1

2

11

Small-scale

0.611

High

703535

MK01
Mitogen-activated protein kinase 1

2

3

Small-scale

0.611

High

421918

A4
Amyloid-beta precursor protein

2

3

High-throughput

0.611

High

370631

FOS
Protein c-Fos

2

17

Small-scale

0.606

High

543487

VDR
Vitamin D3 receptor

2

11

Small-scale

0.606

High

1014537

ZN774
Zinc finger protein 774

2

4

High-throughput

0.606

High

606624

CEBPB
CCAAT/enhancer-binding protein beta

2

8

Small-scale

0.602

High

624241

TFE3
Transcription factor E3

2

4

Small-scale

0.602

High

1014581

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.602

High

608544

DDX5
Probable ATP-dependent RNA helicase DDX5

2

10

Small-scale

0.602

High

585448

VEGFA
Vascular endothelial growth factor A, long form

2

2

Small-scale

0.601

High

1014622

PRD16
Histone-lysine N-methyltransferase PRDM16

2

14

Small-scale

0.601

High

245612

ZEB2
Zinc finger E-box-binding homeobox 2

2

15

Small-scale

0.600

High

798989

BRCA1
Breast cancer type 1 susceptibility protein

2

0

Small-scale

0.598

High

586268

ZEP1
Zinc finger protein 40

2

6

High-throughput

0.595

High

1014678

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

2

7

Small-scale

0.595

High

686801

S10A4
Protein S100-A4

1

4

Small-scale

0.589

High

719129

MPIP1
M-phase inducer phosphatase 1

2

0

Small-scale

0.588

High

652494

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

12

Small-scale

0.586

High

583533

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

9

Small-scale

0.586

High

241395

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

424593

PAI1
Plasminogen activator inhibitor 1

2

3

Small-scale

0.584

High

612972

EGR1
Early growth response protein 1

2

6

Small-scale

0.584

High

789470

PPARG
Peroxisome proliferator-activated receptor gamma

2

14

Small-scale

0.584

High

1014475

RUNX1
Runt-related transcription factor 1

2

16

Small-scale

0.584

High

1014526

EZH2
Histone-lysine N-methyltransferase EZH2

2

11

Small-scale

0.584

High

1014589

TRIB3
Tribbles homolog 3

2

11

Small-scale

0.584

High

633660

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

1014472

DAB2
Disabled homolog 2

1

3

Small-scale

0.578

High

1014504

FHL3
Four and a half LIM domains protein 3

1

13

Small-scale

0.578

High

371759

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.573

High

1014578

RNF31
E3 ubiquitin-protein ligase RNF31

1

3

High-throughput

0.573

High

1014597

MYD88
Myeloid differentiation primary response protein MyD88

1

4

High-throughput

0.573

High

1014605

SETD2
Histone-lysine N-methyltransferase SETD2

1

6

High-throughput

0.573

High

1014607

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

6

High-throughput

0.573

High

1014613

CHRD
Chordin

1

11

High-throughput

0.573

High

1014672

T22D4
TSC22 domain family protein 4

1

2

High-throughput

0.573

High

209980

CRX
Cone-rod homeobox protein

1

9

High-throughput

0.573

High

1014561

TEKT4
Tektin-4

1

1

High-throughput

0.573

High

1014477

FLI1
Friend leukemia integration 1 transcription factor

1

4

High-throughput

0.568

High

289077

DEDD
Death effector domain-containing protein

1

0

Small-scale

0.561

High

180781

TIF1A
Transcription intermediary factor 1-alpha

1

18

Small-scale

0.561

High

413618

P53
Cellular tumor antigen p53

1

4

Small-scale

0.561

High

704938

RBL1
Retinoblastoma-like protein 1

1

1

Small-scale

0.561

High

775522

NU214
Nuclear pore complex protein Nup214

1

5

Small-scale

0.561

High

833916

HNF4A
Hepatocyte nuclear factor 4-alpha

1

10

Small-scale

0.561

High

857411

NOTC1
Neurogenic locus notch homolog protein 1

1

12

Small-scale

0.561

High

886446

CTCF
Transcriptional repressor CTCF

1

5

Small-scale

0.561

High

887412

CEBPD
CCAAT/enhancer-binding protein delta

1

14

Small-scale

0.561

High

890811

TSC2
Tuberin

1

1

Small-scale

0.561

High

904274

BRCA2
Breast cancer type 2 susceptibility protein

1

1

Small-scale

0.561

High

940915

HDAC4
Histone deacetylase 4

1

17

Small-scale

0.561

High

1006894

KC1G2
Casein kinase I isoform gamma-2

1

13

Small-scale

0.561

High

1014483

FOXM1
Forkhead box protein M1

1

5

Small-scale

0.561

High

1014491

HYAL2
Hyaluronidase-2

1

2

Small-scale

0.561

High

1014503

FHL1
Four and a half LIM domains protein 1

1

17

Small-scale

0.561

High

1014511

FHL2
Four and a half LIM domains protein 2

1

13

Small-scale

0.561

High

1014516

IMB1
Importin subunit beta-1

1

8

Small-scale

0.561

High

1014551

MYCD
Myocardin

1

6

Small-scale

0.561

High

1014555

EID2
EP300-interacting inhibitor of differentiation 2

1

2

Small-scale

0.561

High

1014568

KAT6A
Histone acetyltransferase KAT6A

1

4

Small-scale

0.561

High

1014579

OTUB1
Ubiquitin thioesterase OTUB1

1

5

Small-scale

0.561

High

1014598

CITE2
Cbp/p300-interacting transactivator 2

1

2

Small-scale

0.561

High

1014601

TRI62
E3 ubiquitin-protein ligase TRIM62

1

2

Small-scale

0.561

High

1014629

SH22A
SH2 domain-containing protein 2A

1

6

Small-scale

0.561

High

1014655

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

16

Small-scale

0.561

High

1014656

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.561

High

1014663

HDAC5
Histone deacetylase 5

1

17

Small-scale

0.561

High

1014682

PIAS3
E3 SUMO-protein ligase PIAS3

1

16

Small-scale

0.561

High

1014606

DOCK9
Dedicator of cytokinesis protein 9

1

4

Small-scale

0.554

High

503699

SBK3
Uncharacterized serine/threonine-protein kinase SBK3

2

10

High-throughput

0.553

High

1014529

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

High-throughput

0.549

High

1014531

ZC12A
Endoribonuclease ZC3H12A

1

0

High-throughput

0.549

High

193003

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

High-throughput

0.541

High

211226

HXC11
Homeobox protein Hox-C11

1

18

High-throughput

0.541

High

273991

CREST
Calcium-responsive transactivator

1

6

High-throughput

0.541

High

298899

DNJB5
DnaJ homolog subfamily B member 5

1

4

High-throughput

0.541

High

339156

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

1

High-throughput

0.541

High

654488

FBLN1
Fibulin-1

1

9

High-throughput

0.541

High

695208

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.541

High

961476

ISL1
Insulin gene enhancer protein ISL-1

1

3

High-throughput

0.541

High

965619

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

High-throughput

0.541

High

1014479

TF65
Transcription factor p65

1

7

High-throughput

0.541

High

1014510

GIT2
ARF GTPase-activating protein GIT2

1

7

High-throughput

0.541

High

1014602

RIOK2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.541

High

1014617

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

5

High-throughput

0.541

High

1014527

E2F4
Transcription factor E2F4

1

0

Small-scale

0.537

High

1014576

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.536

High

517464

GLI2
Zinc finger protein GLI2

1

8

Small-scale

0.536

High

1014480

SRY
Sex-determining region Y protein

1

13

Small-scale

0.536

High

1014535

KCD16
BTB/POZ domain-containing protein KCTD16

1

2

High-throughput

0.536

High

1014546

LSR
Lipolysis-stimulated lipoprotein receptor

1

2

High-throughput

0.536

High

1014550

TM192
Transmembrane protein 192

1

2

High-throughput

0.536

High

1014632

HINT3
Adenosine 5'-monophosphoramidase HINT3

1

1

High-throughput

0.536

High

1014649

ZF69B
Zinc finger protein 69 homolog B

1

2

High-throughput

0.536

High

983759

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.529

High

189144

IPO8
Importin-8

1

6

Small-scale

0.527

High

603638

JUNB
Transcription factor JunB

1

9

Small-scale

0.527

High

1014532

CPTP
Ceramide-1-phosphate transfer protein

1

0

High-throughput

0.518

High

1014571

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.518

High

1014638

AATF
Protein AATF

1

0

High-throughput

0.518

High

64661

FA83G
Protein FAM83G

1

2

Small-scale

0.515

High

177844

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

6

Small-scale

0.515

High

224265

BUB3
Mitotic checkpoint protein BUB3

1

6

Small-scale

0.515

High

245456

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

1

Small-scale

0.515

High

258837

DNJA2
DnaJ homolog subfamily A member 2

1

5

Small-scale

0.515

High

550230

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.515

High

592640

ITB4
Integrin beta-4

1

2

Small-scale

0.515

High

664039

PRTN3
Myeloblastin

1

5

Small-scale

0.515

High

685504

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

Small-scale

0.515

High

711095

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

2

Small-scale

0.515

High

772483

IRS1
Insulin receptor substrate 1

1

5

Small-scale

0.515

High

913641

VAV2
Guanine nucleotide exchange factor VAV2

1

4

Small-scale

0.515

High

952744

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.515

High

964578

DCAF7
DDB1- and CUL4-associated factor 7

1

2

Small-scale

0.515

High

1014473

FOXO4
Forkhead box protein O4

1

19

Small-scale

0.515

High

1014487

SRBP2
Sterol regulatory element-binding protein 2

1

8

Small-scale

0.515

High

1014502

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

15

Small-scale

0.515

High

1014506

KLF5
Krueppel-like factor 5

1

12

Small-scale

0.515

High

1014514

DHX8
ATP-dependent RNA helicase DHX8

1

2

Small-scale

0.515

High

1014521

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

3

Small-scale

0.515

High

1014556

PJA1
E3 ubiquitin-protein ligase Praja-1

1

8

Small-scale

0.515

High

1014562

ATX2L
Ataxin-2-like protein

1

5

Small-scale

0.515

High

1014563

PSPC1
Paraspeckle component 1

1

5

Small-scale

0.515

High

1014586

MED15
Mediator of RNA polymerase II transcription subunit 15

1

20

Small-scale

0.515

High

1014592

HTF4
Transcription factor 12

1

2

Small-scale

0.515

High

1014593

NOTC4
Neurogenic locus notch homolog protein 4

1

12

Small-scale

0.515

High

1014599

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

1

Small-scale

0.515

High

1014603

SARG
Specifically androgen-regulated gene protein

1

1

Small-scale

0.515

High

1014625

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

2

Small-scale

0.515

High

1014626

E41L5
Band 4.1-like protein 5

1

2

Small-scale

0.515

High

1014639

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

9

Small-scale

0.515

High

1014647

DACH1
Dachshund homolog 1

1

2

Small-scale

0.515

High

1014662

CD11A
Cyclin-dependent kinase 11A

1

3

Small-scale

0.515

High

1014666

SIK3
Serine/threonine-protein kinase SIK3

1

2

Small-scale

0.515

High

1014668

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

12

Small-scale

0.515

High

1014676

YTHD2
YTH domain-containing family protein 2

1

1

Small-scale

0.515

High

605639

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

13

High-throughput

0.515

High

699695

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.515

High

712849

CASP1
Caspase-1

1

1

High-throughput

0.515

High

1014482

APLP2
Amyloid beta precursor like protein 2

1

3

High-throughput

0.515

High

1014564

JPH3
Junctophilin-3

1

2

High-throughput

0.515

High

1014664

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.515

High

488769

FURIN
Furin

1

0

High-throughput

0.513

High

718384

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.513

High

1014621

UD110
UDP-glucuronosyltransferase 1A10

1

0

High-throughput

0.513

High

127932

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

4

High-throughput

0.508

High

245689

GANP
Germinal-center associated nuclear protein

1

5

High-throughput

0.508

High

472643

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.508

High

558039

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.508

High

637454

FLNA
Filamin-A

1

4

High-throughput

0.508

High

642540

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.508

High

717771

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.508

High

903044

ZNF83
Zinc finger protein 83

1

3

High-throughput

0.508

High

1014481

ZBT16
Zinc finger and BTB domain-containing protein 16

1

4

High-throughput

0.508

High

1014492

ANK3
Ankyrin-3

1

3

High-throughput

0.508

High

1014494

PAPP1
Pappalysin-1

1

11

High-throughput

0.508

High

1014512

IL27B
Interleukin-27 subunit beta

1

2

High-throughput

0.508

High

1014515

NCOA6
Nuclear receptor coactivator 6

1

8

High-throughput

0.508

High

1014530

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

10

High-throughput

0.508

High

1014536

PLAG1
Zinc finger protein PLAG1

1

7

High-throughput

0.508

High

1014542

CXXC5
CXXC-type zinc finger protein 5

1

3

High-throughput

0.508

High

1014545

ZN329
Zinc finger protein 329

1

2

High-throughput

0.508

High

1014590

RANB9
Ran-binding protein 9

1

6

High-throughput

0.508

High

1014596

EPAS1
Endothelial PAS domain-containing protein 1

1

8

High-throughput

0.508

High

1014610

SP130
Histone deacetylase complex subunit SAP130

1

4

High-throughput

0.508

High

1014631

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

1

6

High-throughput

0.508

High

1014652

GGA1
ADP-ribosylation factor-binding protein GGA1

1

6

High-throughput

0.508

High

1014654

PRDM4
PR domain zinc finger protein 4

1

2

High-throughput

0.508

High

1014657

PLAL1
Zinc finger protein PLAGL1

1

8

High-throughput

0.508

High

1014658

KMT2B
Histone-lysine N-methyltransferase 2B

1

14

High-throughput

0.508

High

1014667

KDM2A
Lysine-specific demethylase 2A

1

3

High-throughput

0.508

High

1014674

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.508

High

1014677

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

4

High-throughput

0.508

High

1014679

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

1

High-throughput

0.508

High

159335

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

16

Small-scale

0.501

High

179709

MDM4
Protein Mdm4

1

1

Small-scale

0.501

High

297792

PIAS2
E3 SUMO-protein ligase PIAS2

1

16

Small-scale

0.501

High

440026

LCK
Tyrosine-protein kinase Lck

1

2

Small-scale

0.501

High

549118

CDK4
Cyclin-dependent kinase 4

1

4

Small-scale

0.501

High

605070

JUND
Transcription factor JunD

1

10

Small-scale

0.501

High

660605

IF4B
Eukaryotic translation initiation factor 4B

1

2

Small-scale

0.501

High

667769

CDK2
Cyclin-dependent kinase 2

1

2

Small-scale

0.501

High

776947

PPM1A
Protein phosphatase 1A

1

2

Small-scale

0.501

High

838982

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

Small-scale

0.501

High

881507

CDK8
Cyclin-dependent kinase 8

1

10

Small-scale

0.501

High

886746

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

Small-scale

0.501

High

890303

NU153
Nuclear pore complex protein Nup153

1

12

Small-scale

0.501

High

897740

CDK9
Cyclin-dependent kinase 9

1

7

Small-scale

0.501

High

959560

MAX
Protein max

1

9

Small-scale

0.501

High

1014489

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

Small-scale

0.501

High

1014558

PARD3
Partitioning defective 3 homolog

1

7

Small-scale

0.501

High

1014591

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.501

High

1014614

HIPK2
Homeodomain-interacting protein kinase 2

1

18

Small-scale

0.501

High

1014651

DNM3L
DNA

1

2

Small-scale

0.501

High

1014634

RNC
Ribonuclease 3

1

3

Small-scale

0.500

High

610622

TCPA
T-complex protein 1 subunit alpha

1

0

Small-scale

0.493

High

785100

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.493

High

810044

RL3
Large ribosomal subunit protein uL3

1

0

Small-scale

0.493

High

1014604

RFIP5
Rab11 family-interacting protein 5

1

0

Small-scale

0.493

High

428710

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.486

High

1014485

PCDH1
Protocadherin-1

1

0

High-throughput

0.486

High

1014495

TMED1
Transmembrane emp24 domain-containing protein 1

1

0

High-throughput

0.486

High

1014543

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.486

High

1014619

VISTA
V-type immunoglobulin domain-containing suppressor of T-cell activation

1

0

High-throughput

0.486

High

126304

TLR4
Toll-like receptor 4

1

1

High-throughput

0.481

High

366342

PLMN
Plasminogen

1

2

High-throughput

0.481

High

724383

COR1A
Coronin-1A

1

2

High-throughput

0.481

High

1014519

ZMY11
Zinc finger MYND domain-containing protein 11

1

20

High-throughput

0.481

High

1014565

ZCH14
Zinc finger CCHC domain-containing protein 14

1

7

High-throughput

0.481

High

1014635

UBQL4
Ubiquilin-4

1

6

High-throughput

0.481

High

1014636

FAME
Factor associated with metabolism and energy

1

1

High-throughput

0.481

High

1014643

DNJB4
DnaJ homolog subfamily B member 4

1

4

High-throughput

0.481

High

1014653

PARP4
Protein mono-ADP-ribosyltransferase PARP4

1

1

High-throughput

0.481

High

1014584

XPO6
Exportin-6

1

0

Small-scale

0.480

High

128966

MEN1
Menin

1

5

Small-scale

0.479

High

141421

DDX3X
ATP-dependent RNA helicase DDX3X

1

11

Small-scale

0.479

High

154668

ARI1A
AT-rich interactive domain-containing protein 1A

1

17

Small-scale

0.479

High

166515

BACH1
Transcription regulator protein BACH1

1

8

Small-scale

0.479

High

169512

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

9

Small-scale

0.479

High

176055

KDM6B
Lysine-specific demethylase 6B

1

6

Small-scale

0.479

High

193101

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

11

Small-scale

0.479

High

216414

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

6

Small-scale

0.479

High

282369

MED24
Mediator of RNA polymerase II transcription subunit 24

1

5

Small-scale

0.479

High

287781

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

Small-scale

0.479

High

288389

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

13

Small-scale

0.479

High

384132

CO1A1
Collagen alpha-1(I) chain

1

16

Small-scale

0.479

High

395904

ESR1
Estrogen receptor

1

14

Small-scale

0.479

High

488452

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

7

Small-scale

0.479

High

507832

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.479

High

520553

RARA
Retinoic acid receptor alpha

1

11

Small-scale

0.479

High

639712

TAF1
Transcription initiation factor TFIID subunit 1

1

20

Small-scale

0.479

High

651278

CBL
E3 ubiquitin-protein ligase CBL

1

7

Small-scale

0.479

High

685154

PAX6
Paired box protein Pax-6

1

4

Small-scale

0.479

High

714027

PML
Protein PML

1

7

Small-scale

0.479

High

718541

CDC27
Cell division cycle protein 27 homolog

1

6

Small-scale

0.479

High

728168

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.479

High

761635

HSP74
Heat shock 70 kDa protein 4

1

2

Small-scale

0.479

High

767164

MERL
Merlin

1

2

High-throughput

0.479

High

776287

SOX11
Transcription factor SOX-11

1

15

Small-scale

0.479

High

787287

ACV1B
Activin receptor type-1B

1

20

Small-scale

0.479

High

788896

TGFR2
TGF-beta receptor type-2

1

20

Small-scale

0.479

High

790021

ZEB1
Zinc finger E-box-binding homeobox 1

1

20

Small-scale

0.479

High

808020

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

Small-scale

0.479

High

832302

ID1
DNA-binding protein inhibitor ID-1

1

1

Small-scale

0.479

High

833721

KDM5C
Lysine-specific demethylase 5C

1

5

Small-scale

0.479

High

858628

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

17

High-throughput

0.479

High

862035

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.479

High

873073

SOX9
Transcription factor SOX-9

1

17

Small-scale

0.479

High

897451

TOB1
Protein Tob1

1

12

Small-scale

0.479

High

903313

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

2

Small-scale

0.479

High

937712

FOXA1
Hepatocyte nuclear factor 3-alpha

1

11

Small-scale

0.479

High

945698

FOXL2
Forkhead box protein L2

1

7

Small-scale

0.479

High

987541

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.479

High

1005570

PITX1
Pituitary homeobox 1

1

5

Small-scale

0.479

High

1014474

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

5

Small-scale

0.479

High

1014476

RELB
Transcription factor RelB

1

7

Small-scale

0.479

High

1014488

FOXO1
Forkhead box protein O1

1

19

Small-scale

0.479

High

1014493

CDC16
Cell division cycle protein 16 homolog

1

6

Small-scale

0.479

High

1014501

CUL1
Cullin-1

1

7

Small-scale

0.479

High

1014508

NFYC
Nuclear transcription factor Y subunit gamma

1

2

Small-scale

0.479

High

1014509

ARHG7
Rho guanine nucleotide exchange factor 7

1

2

Small-scale

0.479

High

1014518

RBBP5
Retinoblastoma-binding protein 5

1

3

Small-scale

0.479

High

1014523

NCOA1
Nuclear receptor coactivator 1

1

9

Small-scale

0.479

High

1014534

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1014538

TAF2
Transcription initiation factor TFIID subunit 2

1

1

Small-scale

0.479

High

1014541

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1014544

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

3

Small-scale

0.479

High

1014547

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

3

Small-scale

0.479

High

1014557

SMRC2
SWI/SNF complex subunit SMARCC2

1

16

Small-scale

0.479

High

1014559

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

15

Small-scale

0.479

High

1014569

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.479

High

1014572

SMRC1
SWI/SNF complex subunit SMARCC1

1

7

Small-scale

0.479

High

1014574

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

Small-scale

0.479

High

1014577

MRTFA
Myocardin-related transcription factor A

1

17

Small-scale

0.479

High

1014580

PDLI5
PDZ and LIM domain protein 5

1

7

Small-scale

0.479

High

1014585

CIC
Protein capicua homolog

1

12

High-throughput

0.479

High

1014594

PITX2
Pituitary homeobox 2

1

5

Small-scale

0.479

High

1014600

OVOL2
Transcription factor Ovo-like 2

1

7

Small-scale

0.479

High

1014608

TGIF2
Homeobox protein TGIF2

1

11

Small-scale

0.479

High

1014615

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1014616

RGCC
Regulator of cell cycle RGCC

1

1

Small-scale

0.479

High

1014618

RANB3
Ran-binding protein 3

1

1

Small-scale

0.479

High

1014623

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

Small-scale

0.479

High

1014630

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

Small-scale

0.479

High

1014633

DDX4
Probable ATP-dependent RNA helicase DDX4

1

11

Small-scale

0.479

High

1014641

IL37
Interleukin-37

1

1

Small-scale

0.479

High

1014645

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1014665

FBW1A
F-box/WD repeat-containing protein 1A

1

5

Small-scale

0.479

High

1014670

MED16
Mediator of RNA polymerase II transcription subunit 16

1

2

Small-scale

0.479

High

1014671

STRAP
Serine-threonine kinase receptor-associated protein

1

8

Small-scale

0.479

High

1014673

GRIP1
Glutamate receptor-interacting protein 1

1

2

Small-scale

0.479

High

1014681

NCOA3
Nuclear receptor coactivator 3

1

10

Small-scale

0.479

High

292115

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

3

Small-scale

0.470

High

1014583

CSMD1
CUB and sushi domain-containing protein 1

1

7

Small-scale

0.470

High

1014680

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

1

Small-scale

0.470

High

97279

E9PSE9
Coiled-coil domain containing 198

1

1

High-throughput

0.470

High

424112

CP11A
Cholesterol side-chain cleavage enzyme, mitochondrial

1

3

High-throughput

0.464

High

390885

TRFE
Serotransferrin

1

0

High-throughput

0.460

High

403158

APOB
Apolipoprotein B-100

1

0

High-throughput

0.460

High

1014566

PROX1
Prospero homeobox protein 1

1

0

High-throughput

0.460

High

1014646

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

253401

MAFK
Transcription factor MafK

1

0

Small-scale

0.458

High

347645

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

376804

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

985128

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

1014517

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1014522

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1014540

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1014560

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1014587

Q96RS2
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

1014660

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

0

High-throughput

0.458

High

851744

NKX21
Homeobox protein Nkx-2.1

1

9

Small-scale

0.457

High

159606

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

11

Small-scale

0.445

High

1014627

JPH1
Junctophilin-1

1

1

Small-scale

0.445

High

1014642

I36RA
Interleukin-36 receptor antagonist protein

1

1

Small-scale

0.445

High

366169

HPT
Haptoglobin

1

3

High-throughput

0.439

High

472294

CFAH
Complement factor H

1

10

High-throughput

0.439

High

516042

CSH2
Chorionic somatomammotropin hormone 2

1

4

High-throughput

0.439

High

105756

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1014533

OTUD1
OTU domain-containing protein 1

1

1

Small-scale

0.437

High

566129

K1C10
Keratin, type I cytoskeletal 10

1

0

Small-scale

0.426

High

772601

GDE
Glycogen debranching enzyme

1

0

Small-scale

0.426

High

1008011

P78451
Somatomammotropin

1

4

High-throughput

0.417

High

566630

PDIA4
Protein disulfide-isomerase A4

1

2

High-throughput

0.407

High

1014553

CCD33
Coiled-coil domain-containing protein 33

4

0

High-throughput

0.362

High

1014548

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

767525

RECO
Recoverin

1

0

High-throughput

0.282

High

1014637

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

1014644

CFDP1
Craniofacial development protein 1

1

0

High-throughput

0.265

Low

1014648

SIA7B
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

1

0

High-throughput

0.265

Low

613894

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.251

Low

1014628

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.251

Low

482239

PAEP
Glycodelin

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025