Protein: TIAM1
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)

Gene: TIAM1
Organism: Homo sapiens
Interactions: 200
UniProt ID: Q13009

Gene Ontology (top 5):
GO:0003300 - cardiac muscle hypertrophy
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005874 - microtubule
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925241

RAC1
Ras-related C3 botulinum toxin substrate 1

4

20

Small-scale

0.878

High

159201

CSKP
Peripheral plasma membrane protein CASK

3

19

Small-scale

0.864

High

893952

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

900428

RHOA
Transforming protein RhoA

2

20

High-throughput

0.768

High

350128

RASK
GTPase KRas

2

18

High-throughput

0.754

High

915642

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1022426

PARD3
Partitioning defective 3 homolog

2

10

Small-scale

0.754

High

1022475

FBW1A
F-box/WD repeat-containing protein 1A

1

9

Small-scale

0.747

High

1022389

SNTB2
Beta-2-syntrophin

2

9

High-throughput

0.737

High

904505

1433G
14-3-3 protein gamma

6

20

High-throughput

0.730

High

822003

KC1A
Casein kinase I isoform alpha

1

5

Small-scale

0.724

High

1022440

NEB2
Neurabin-2

1

20

Small-scale

0.713

High

981966

1433F
14-3-3 protein eta

5

20

High-throughput

0.709

High

164119

ARHGA
Rho guanine nucleotide exchange factor 10

1

17

High-throughput

0.698

High

592656

RAB6A
Ras-related protein Rab-6A

1

3

High-throughput

0.698

High

942336

DLG4
Disks large homolog 4

1

10

High-throughput

0.698

High

1021484

DLG1
Disks large homolog 1

1

10

High-throughput

0.698

High

1022476

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

20

High-throughput

0.698

High

549889

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

9

High-throughput

0.691

High

1022452

WNK1
Serine/threonine-protein kinase WNK1

1

17

High-throughput

0.691

High

646851

1433T
14-3-3 protein theta

4

20

High-throughput

0.691

High

683307

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

926988

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.691

High

349282

RASH
GTPase HRas

1

14

Small-scale

0.665

High

909501

1433E
14-3-3 protein epsilon

3

9

High-throughput

0.656

High

397159

KPCG
Protein kinase C gamma type

1

20

Small-scale

0.647

High

408612

KPCB
Protein kinase C beta type

1

19

Small-scale

0.647

High

566377

KPCA
Protein kinase C alpha type

1

19

Small-scale

0.647

High

930821

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

Small-scale

0.647

High

969077

KPCE
Protein kinase C epsilon type

1

19

Small-scale

0.647

High

983819

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.647

High

984488

KPCD
Protein kinase C delta type

1

19

Small-scale

0.647

High

1022388

SNTA1
Alpha-1-syntrophin

1

12

High-throughput

0.625

High

1022464

NRBP
Nuclear receptor-binding protein

1

2

High-throughput

0.625

High

166557

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

High-throughput

0.618

High

196437

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.618

High

216926

KIF1C
Kinesin-like protein KIF1C

1

9

High-throughput

0.618

High

253347

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

7

High-throughput

0.618

High

318122

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.618

High

348640

RASN
GTPase NRas

1

18

High-throughput

0.618

High

433734

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.618

High

564502

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

830340

KC1E
Casein kinase I isoform epsilon

1

13

Small-scale

0.618

High

895058

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.618

High

912879

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.618

High

950956

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

960360

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.618

High

997146

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

10

High-throughput

0.618

High

1022387

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

8

Small-scale

0.618

High

1022390

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

10

High-throughput

0.618

High

1022394

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

1022402

SPD2A
SH3 and PX domain-containing protein 2A

1

19

High-throughput

0.618

High

1022406

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.618

High

1022412

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1022415

PHLB2
Pleckstrin homology-like domain family B member 2

1

14

High-throughput

0.618

High

1022420

KSR1
Kinase suppressor of Ras 1

1

14

High-throughput

0.618

High

1022438

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

12

High-throughput

0.618

High

1022443

RTKN
Rhotekin

1

2

High-throughput

0.618

High

1022453

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1022454

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1022455

KI13B
Kinesin-like protein KIF13B

1

9

High-throughput

0.618

High

1022458

LIN7C
Protein lin-7 homolog C

1

15

High-throughput

0.618

High

1022470

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.618

High

1022474

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

8

Small-scale

0.618

High

1022461

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.586

High

513853

DMD
Dystrophin

2

17

High-throughput

0.571

High

880247

MAZ
Myc-associated zinc finger protein

2

2

High-throughput

0.571

High

1022407

FIP1
Pre-mRNA 3'-end-processing factor FIP1

2

1

High-throughput

0.571

High

1022478

DTNA
Dystrobrevin alpha

2

1

High-throughput

0.571

High

578841

SDC1
Syndecan-1

1

4

Small-scale

0.566

High

156279

PSA7
Proteasome subunit alpha type-7

1

1

High-throughput

0.561

High

346660

MYC
Myc proto-oncogene protein

1

9

Small-scale

0.561

High

556699

ANK1
Ankyrin-1

1

11

Small-scale

0.561

High

1022400

FND3B
Fibronectin type III domain-containing protein 3B

1

8

Small-scale

0.555

High

230868

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

15

High-throughput

0.553

High

1022401

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

6

High-throughput

0.553

High

1022439

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.553

High

1022446

WDR33
pre-mRNA 3' end processing protein WDR33

1

8

High-throughput

0.553

High

1022473

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

17

High-throughput

0.553

High

64279

ABTB3
Ankyrin repeat and BTB/POZ domain-containing protein 3

1

10

High-throughput

0.541

High

131831

KRIT1
Krev interaction trapped protein 1

1

7

High-throughput

0.541

High

213538

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

High-throughput

0.541

High

359008

CRYAB
Alpha-crystallin B chain

1

2

High-throughput

0.541

High

827183

ARRB1
Beta-arrestin-1

1

2

High-throughput

0.541

High

843456

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

1

High-throughput

0.541

High

849096

DHB4
Peroxisomal multifunctional enzyme type 2

1

1

High-throughput

0.541

High

1022416

DAAM2
Disheveled-associated activator of morphogenesis 2

1

1

High-throughput

0.541

High

1022430

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

High-throughput

0.541

High

1022434

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.541

High

1022450

ATG5
Autophagy protein 5

1

1

High-throughput

0.541

High

1022459

TBC23
TBC1 domain family member 23

1

1

High-throughput

0.541

High

1022466

MBD1
Methyl-CpG-binding domain protein 1

1

1

High-throughput

0.541

High

529053

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.536

High

1019711

ILF3
Interleukin enhancer-binding factor 3

1

1

High-throughput

0.536

High

1022393

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

Small-scale

0.523

High

1022437

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

2

1

High-throughput

0.521

High

169839

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.518

High

179411

MRP5
ATP-binding cassette sub-family C member 5

1

0

High-throughput

0.518

High

805653

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.518

High

1022399

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.518

High

1022421

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.518

High

1022447

SENP6
Sentrin-specific protease 6

1

0

High-throughput

0.518

High

1022449

SHRPN
Sharpin

1

0

High-throughput

0.518

High

1022467

ENPP5
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5

1

0

High-throughput

0.518

High

253704

SDC3
Syndecan-3

1

6

Small-scale

0.501

High

475688

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

555135

CD44
CD44 antigen

1

4

Small-scale

0.501

High

680358

SDC4
Syndecan-4

1

2

Small-scale

0.501

High

713085

SDC2
Syndecan-2

1

3

Small-scale

0.501

High

229795

ZN292
Zinc finger protein 292

1

1

High-throughput

0.494

High

442116

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.494

High

508490

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.494

High

825822

NASP
Nuclear autoantigenic sperm protein

1

3

High-throughput

0.494

High

879674

ATPK
ATP synthase subunit f, mitochondrial

1

1

High-throughput

0.494

High

881800

SOX10
Transcription factor SOX-10

1

2

High-throughput

0.494

High

1022395

RYR3
Ryanodine receptor 3

1

3

High-throughput

0.494

High

1022397

NDF2
Neurogenic differentiation factor 2

1

2

High-throughput

0.494

High

1022410

ZN793
Zinc finger protein 793

1

3

High-throughput

0.494

High

1022419

DZIP1
Cilium assembly protein DZIP1

1

12

High-throughput

0.494

High

1022423

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.494

High

1022431

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

2

High-throughput

0.494

High

1022436

ZN558
Zinc finger protein 558

1

1

High-throughput

0.494

High

1022448

ZN350
Zinc finger protein 350

1

2

High-throughput

0.494

High

1022422

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

11

High-throughput

0.489

High

1022385

SRSF5
Serine/arginine-rich splicing factor 5

1

2

Small-scale

0.481

High

1022429

CBP
CREB-binding protein

1

3

Small-scale

0.481

High

178513

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

236757

CCNT1
Cyclin-T1

1

5

High-throughput

0.479

High

264301

GGYF1
GRB10-interacting GYF protein 1

1

9

High-throughput

0.479

High

279536

FLOT1
Flotillin-1

1

10

High-throughput

0.479

High

316249

NADK
NAD kinase

1

1

High-throughput

0.479

High

506996

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

548903

NDKA
Nucleoside diphosphate kinase A

1

3

Small-scale

0.479

High

567037

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

598469

NF1
Neurofibromin

1

8

High-throughput

0.479

High

673475

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

673575

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

684005

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

793295

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

880704

HDAC4
Histone deacetylase 4

1

14

High-throughput

0.479

High

974790

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1021392

ANK3
Ankyrin-3

1

10

Small-scale

0.479

High

1022386

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

1022391

CUL4B
Cullin-4B

1

9

High-throughput

0.479

High

1022398

OCLN
Occludin

1

3

High-throughput

0.479

High

1022404

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.479

High

1022409

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.479

High

1022411

SYDE1
Rho GTPase-activating protein SYDE1

1

6

High-throughput

0.479

High

1022417

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

6

Small-scale

0.479

High

1022418

DDX42
ATP-dependent RNA helicase DDX42

1

2

High-throughput

0.479

High

1022424

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1022425

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1022427

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

5

Small-scale

0.479

High

1022442

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1022451

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

1022456

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

6

High-throughput

0.479

High

1022462

CING
Cingulin

1

5

High-throughput

0.479

High

1022463

LIMA1
LIM domain and actin-binding protein 1

1

10

High-throughput

0.479

High

1022468

NGAP
Ras GTPase-activating protein nGAP

1

7

High-throughput

0.479

High

1022469

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1022471

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1022472

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1022477

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1022479

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.479

High

1022444

OSBL1
Oxysterol-binding protein-related protein 1

1

0

Small-scale

0.460

High

237208

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

390202

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

1022414

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1022441

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1022435

SPTCS
Spatacsin

1

2

Small-scale

0.457

High

162685

XPO1
Exportin-1

1

4

High-throughput

0.445

High

353930

IGHM
Immunoglobulin heavy constant mu

1

6

High-throughput

0.445

High

354057

IGHA1
Immunoglobulin heavy constant alpha 1

1

3

High-throughput

0.445

High

1022396

SYCP1
Synaptonemal complex protein 1

1

5

Small-scale

0.439

High

1022432

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

3

Small-scale

0.439

High

171212

CTDSL
CTD small phosphatase-like protein

1

3

High-throughput

0.437

High

305435

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

331800

NSD2
Histone-lysine N-methyltransferase NSD2

1

4

Small-scale

0.437

High

839580

SERPH
Serpin H1

1

7

High-throughput

0.437

High

873407

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

3

High-throughput

0.437

High

985664

CTSL2
CTD small phosphatase-like protein 2

1

3

High-throughput

0.437

High

1022392

ZN638
Zinc finger protein 638

1

2

High-throughput

0.437

High

1022405

AN34A
Ankyrin repeat domain-containing protein 34A

1

18

High-throughput

0.437

High

1022408

LRC31
Leucine-rich repeat-containing protein 31

1

3

High-throughput

0.437

High

1022428

SRS12
Serine/arginine-rich splicing factor 12

1

4

High-throughput

0.437

High

1022433

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1022465

ATIF1
ATPase inhibitor, mitochondrial

1

1

High-throughput

0.437

High

1022480

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.437

High

240569

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.282

High

335098

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.282

High

855837

ZN133
Zinc finger protein 133

1

0

High-throughput

0.282

High

952304

H33
Histone H3.3

1

0

High-throughput

0.282

High

1002114

CCD15
Coiled-coil domain-containing protein 15

1

0

High-throughput

0.282

High

1022403

DAAF9
Dynein axonemal assembly factor 9

1

0

High-throughput

0.282

High

1022413

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.282

High

1022457

ZHANG
CREB/ATF bZIP transcription factor

1

0

High-throughput

0.282

High

1022445

CNTP4
Contactin-associated protein-like 4

1

0

Small-scale

0.279

Low

363781

ALBU
Albumin

1

0

High-throughput

0.279

Low

518987

PIP
Prolactin-inducible protein

1

0

High-throughput

0.279

Low

1022460

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024