HitPredict

Interactor 1: PER1 (O15534)
Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)
Gene: PER1

Interactor 2: CRY1 (Q16526)
Cryptochrome-1
Gene: CRY1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 23555304, 25756610, 26186194, 28514442, 10531061, 33961781
Identification Methods two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DNA_photolyase~Period_C, FAD_binding_7~Period_C
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007623 - circadian rhythm
GO:0032922 - circadian regulation of gene expression
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1290
Hs

1 586
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024