HitPredict

Interactor 1: RGS5 (O15539)
Regulator of G-protein signaling 5 (RGS5)
Gene: RGS5

Interactor 2: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	9079700, 11253162
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 355
+	Hs
		391357 RGS3_HUMAN (16-180): 6.47e-66: 219: 52.73		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		391358 RGS4_HUMAN (1-180): 2.89e-71: 216: 52.78		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Hs
		180650 RGS16_HUMAN (1-179): 3.59e-69: 210: 51.11		GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00
+	Rn
		500350 RGS4_RAT (1-179): 4.02e-71: 215: 53.07		GNAI1_RAT (1-355): 6.55e-178: 499: 87.89
+	Hs
		834937 RGS4_HUMAN (1-180): 2.89e-71: 216: 52.78		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		182448 RGS5_HUMAN (1-181): 8.22e-71: 213: 100.00		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		444692 RGS3_HUMAN (16-180): 6.47e-66: 219: 52.73		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		180657 RGS16_HUMAN (1-179): 3.59e-69: 210: 51.11		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		450989 RGS4_HUMAN (1-180): 2.89e-71: 216: 52.78		GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30
+	Hs
		182442 RGS5_HUMAN (1-181): 8.22e-71: 213: 100.00		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		182443 RGS5_HUMAN (1-181): 8.22e-71: 213: 100.00		GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30
+	Hs
		180652 RGS16_HUMAN (1-179): 3.59e-69: 210: 51.11		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		180653 RGS16_HUMAN (1-179): 3.59e-69: 210: 51.11		GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30
+	Rn
		834945 RGS4_RAT (1-179): 4.02e-71: 215: 53.07		GNAO_RAT (1-355): 7.36e-172: 483: 68.45
+	Mm
		579645 RGS16_MOUSE (1-179): 7.89e-69: 209: 48.05		GNAO_MOUSE (1-355): 1.69e-171: 482: 68.45
+	Hs
		834936 RGS4_HUMAN (1-180): 2.89e-71: 216: 52.78		GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42
+	Hs
		182446 RGS5_HUMAN (1-181): 8.22e-71: 213: 100.00		GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42
+	Hs
		670435 RGS3_HUMAN (16-180): 6.47e-66: 219: 52.73		GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42
+	Hs
		180656 RGS16_HUMAN (1-179): 3.59e-69: 210: 51.11		GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42
+	Hs
		180658 RGS16_HUMAN (1-179): 3.59e-69: 210: 51.11		GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72