HitPredict

Interactor 1: MSI1 (O22467)
Histone-binding protein MSI1 (CAF-1 p48 homolog) (Chromatin assembly factor 1 subunit MSI1) (CAF-1 subunit MSI1) (Protein MULTICOPY SUPPRESSOR OF IRA 1) (AtMSI1) (Protein medicis) (WD-40 repeat-containing protein MSI1)
Gene: MSI1

Interactor 2: EZA1 (Q9ZSM8)
Histone-lysine N-methyltransferase EZA1 (EC 2.1.1.356) (CURLY LEAF-like 1) (Protein SET DOMAIN GROUP 10) (Protein SWINGER)
Gene: EZA1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.715

Property	Details
Experiments	23778966
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, protein cross-linking with a bifunctional reagent
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005677 - chromatin silencing complex GO:0031507 - heterochromatin formation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 424 At			1 856
+	At
		186924 MSI1_ARATH (17-424): 1.57e-113: 341: 100.00		CLF_ARATH (13-853): 0: 665: 45.03
+	Dm
		785628 CAF1_DROME (4-424): 1.11e-111: 336: 62.80		EZ_DROME (121-833): 2.68e-105: 344: 23.42
+	Hs
		975233 RBBP4_HUMAN (1-420): 1.48e-112: 338: 65.56		KMT2A_HUMAN (278-842): 1.57e-88: 310: 14.79
+	Hs
		997924 RBBP4_HUMAN (1-420): 1.48e-112: 338: 65.56		ASH1L_HUMAN (203-847): 6.76e-88: 308: 14.61
+	At
		186920 MSI1_ARATH (17-424): 1.57e-113: 341: 100.00		MEDEA_ARATH (23-498): 9.65e-89: 298: 29.30
+	Dm
		1099178 CAF1_DROME (4-424): 1.11e-111: 336: 62.80		ASH1_DROME (316-847): 7.52e-86: 302: 14.41
+	Mm
		222465 RBBP4_MOUSE (1-420): 1.48e-112: 338: 65.56		SUV91_MOUSE (542-841): 1.42e-78: 262: 19.82
+	Mm
		222466 RBBP7_MOUSE (4-423): 2.33e-111: 335: 64.37		SUV91_MOUSE (542-841): 1.42e-78: 262: 19.82
+	Hs
		203672 RBBP4_HUMAN (1-420): 1.48e-112: 338: 65.56		SUV91_HUMAN (542-841): 1.16e-76: 257: 19.82
+	Mm
		1141954 RBBP4_MOUSE (1-420): 1.48e-112: 338: 65.56		EHMT2_MOUSE (555-851): 4.76e-67: 245: 21.18
+	Hs
		165666 RBBP4_HUMAN (1-420): 1.48e-112: 338: 65.56		SET1A_HUMAN (693-832): 1.25e-50: 195: 28.17
+	Mm
		936646 RBBP4_MOUSE (1-420): 1.48e-112: 338: 65.56		EZH1_MOUSE (171-388): 5.23e-37: 151: 19.82
+	Hs
		997839 RBBP4_HUMAN (1-420): 1.48e-112: 338: 65.56		EZH1_HUMAN (171-388): 1.03e-36: 150: 19.82
+	Mm
		936647 RBBP7_MOUSE (4-423): 2.33e-111: 335: 64.37		EZH1_MOUSE (171-388): 5.23e-37: 151: 19.82
+	Hs
		997735 RBBP4_HUMAN (1-420): 1.48e-112: 338: 65.56		EZH2_HUMAN (176-409): 3.54e-36: 148: 16.81
+	Mm
		1141929 RBBP4_MOUSE (1-420): 1.48e-112: 338: 65.56		EZH2_MOUSE (178-409): 1e-35: 147: 16.53
+	Mm
		1141957 RBBP7_MOUSE (4-423): 2.33e-111: 335: 64.37		EZH2_MOUSE (178-409): 1e-35: 147: 16.53
+	Mm
		1141935 RBBP4_MOUSE (1-420): 1.48e-112: 338: 65.56		Q6AXH7_MOUSE (178-409): 1.87e-34: 143: 16.18
+	Mm
		1141960 RBBP7_MOUSE (4-423): 2.33e-111: 335: 64.37		Q6AXH7_MOUSE (178-409): 1.87e-34: 143: 16.18
+	Hs
		267764 TAF5L_HUMAN (3-393): 1.18e-61: 211: 18.59		EZH2_HUMAN (176-409): 3.54e-36: 148: 16.81