HitPredict

Interactor 1: HY5 (O24646)
Transcription factor HY5 (Protein LONG HYPOCOTYL 5) (bZIP transcription factor 56) (AtbZIP56)
Gene: HY5

Interactor 2: COP1 (P43254)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1) (RING-type E3 ubiquitin transferase COP1)
Gene: COP1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	19802365, 10990463, 9755158, 9659918, 21097709, 24610722, 24858936, 14597662, 11226162, 22692212, 23425305
Identification Methods	pull down, two hybrid, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0009585 - red, far-red light phototransduction GO:0009963 - positive regulation of flavonoid biosynthetic process GO:0010224 - response to UV-B
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 168 At			1 675
+	Hs
		831919 CEBPD_HUMAN (14-162): 8.35e-26: 101: 16.78		FBXW7_HUMAN (185-667): 4.17e-79: 268: 13.56
+	Hs
		1281297 CR3L1_HUMAN (29-142): 1.5e-21: 92.3: 21.05		FBXW7_HUMAN (185-667): 4.17e-79: 268: 13.56
+	Mm
		1257400 CR3L1_MOUSE (29-142): 8.93e-21: 89.9: 20.18		FBXW7_MOUSE (185-667): 5.01e-79: 267: 13.56
+	Hs
		402320 JUN_HUMAN (5-151): 8.03e-21: 88.8: 17.76		FBXW7_HUMAN (185-667): 4.17e-79: 268: 13.56
+	Hs
		571822 XBP1_HUMAN (51-168): 1.06e-20: 87.3: 31.11		FBXW7_HUMAN (185-667): 4.17e-79: 268: 13.56
+	At
		1341101 BZP28_ARATH (17-153): 2.59e-22: 94.6: 19.26		WDR5A_ARATH (223-533): 2.04e-49: 177: 12.06
+	Hs
		402335 JUN_HUMAN (5-151): 8.03e-21: 88.8: 17.76		SNR40_HUMAN (537-674): 1.23e-29: 122: 21.83
+	Mm
		959185 CEBPD_MOUSE (8-163): 8.45e-28: 106: 16.67		COP1_MOUSE (502-674): 1.42e-20: 98.6: 15.76
+	At
		189290 HY5_ARATH (1-168): 4.17e-21: 86.1: 100.00		SPA1_ARATH (508-674): 1.28e-22: 105: 16.38
+	Hs
		579360 ATF6A_HUMAN (13-156): 3.34e-21: 91.1: 18.95		COP1_HUMAN (502-674): 9.64e-21: 99: 15.22
+	Hs
		566776 JUNB_HUMAN (34-154): 4.47e-21: 89.6: 22.66		COP1_HUMAN (502-674): 9.64e-21: 99: 15.22
+	At
		794472 Q1H5E5_ARATH (1-168): 4.17e-21: 86.1: 100.00		COP1_ARATH (508-674): 7.27e-22: 102: 14.12
+	Hs
		402265 JUN_HUMAN (5-151): 8.03e-21: 88.8: 17.76		COP1_HUMAN (502-674): 9.64e-21: 99: 15.22
+	At
		794482 HYH_ARATH (35-156): 6.31e-21: 85.3: 50.00		COP1_ARATH (508-674): 7.27e-22: 102: 14.12
+	Hs
		402083 JUN_HUMAN (5-151): 8.03e-21: 88.8: 17.76		RBBP7_HUMAN (452-674): 5.17e-21: 98: 17.34
+	Hs
		402538 JUN_HUMAN (5-151): 8.03e-21: 88.8: 17.76		NLE1_HUMAN (581-674): 3.09e-20: 96.3: 14.89
+	Hs
		401754 JUN_HUMAN (5-151): 8.03e-21: 88.8: 17.76		WDR5_HUMAN (582-675): 8.48e-20: 93.2: 21.28
+	Hs
		569504 CEBPB_HUMAN (53-150): 1.86e-18: 82.6: 19.39		WDR5_HUMAN (582-675): 8.48e-20: 93.2: 21.28
+	Hs
		401900 JUN_HUMAN (5-151): 8.03e-21: 88.8: 17.76		RBBP4_HUMAN (500-673): 8.63e-16: 82.2: 17.01
+	Hs
		569650 CEBPB_HUMAN (53-150): 1.86e-18: 82.6: 19.39		RBBP4_HUMAN (500-673): 8.63e-16: 82.2: 17.01