Protein: IPO8
Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)

Gene: IPO8
Organism: Homo sapiens
Interactions: 254
UniProt ID: O15397

Gene Ontology (top 5):
GO:0005635 - nuclear envelope
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

189094

RALB
Ras-related protein Ral-B

2

4

High-throughput

0.737

High

189142

RAC1
Ras-related C3 botulinum toxin substrate 1

2

13

High-throughput

0.737

High

189304

TN13B
Tumor necrosis factor ligand superfamily member 13B

4

8

High-throughput

0.699

High

189154

TIF1B
Transcription intermediary factor 1-beta

3

8

High-throughput

0.675

High

189270

REPI1
DNA-binding protein REPIN1

3

16

High-throughput

0.675

High

189124

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

14

High-throughput

0.667

High

189158

CUL3
Cullin-3

3

10

High-throughput

0.656

High

189141

RAN
GTP-binding nuclear protein Ran

1

20

Small-scale

0.647

High

189297

AGO2
Protein argonaute-2

2

5

High-throughput

0.635

High

189244

ZBT10
Zinc finger and BTB domain-containing protein 10

2

19

High-throughput

0.628

High

189136

H2B1D
Histone H2B type 1-D

1

15

High-throughput

0.618

High

189138

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.618

High

189241

H2B1A
Histone H2B type 1-A

1

14

High-throughput

0.618

High

189269

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

3

20

High-throughput

0.616

High

189289

ZN331
Zinc finger protein 331

3

19

High-throughput

0.616

High

189132

AK1C2
Aldo-keto reductase family 1 member C2

2

1

High-throughput

0.611

High

189105

WT1
Wilms tumor protein

2

20

High-throughput

0.606

High

189192

ZFP1
Zinc finger protein 1 homolog

3

20

High-throughput

0.604

High

189222

SIGL1
SIGLEC family-like protein 1

3

6

High-throughput

0.604

High

189139

1433E
14-3-3 protein epsilon

2

2

Small-scale

0.601

High

189172

ZNF74
Zinc finger protein 74

2

18

High-throughput

0.601

High

189211

Z354C
Zinc finger protein 354C

2

12

High-throughput

0.601

High

189089

IF4E
Eukaryotic translation initiation factor 4E

2

0

Small-scale

0.598

High

189281

AGO3
Protein argonaute-3

1

5

High-throughput

0.586

High

189285

AGO4
Protein argonaute-4

1

5

High-throughput

0.586

High

189298

AGO1
Protein argonaute-1

1

5

High-throughput

0.578

High

189162

ZN460
Zinc finger protein 460

2

15

High-throughput

0.574

High

189182

HP1B3
Heterochromatin protein 1-binding protein 3

2

2

High-throughput

0.574

High

189293

ZN629
Zinc finger protein 629

2

10

High-throughput

0.574

High

189129

PAXI
Paxillin

2

20

High-throughput

0.571

High

189292

RHG23
Rho GTPase-activating protein 23

2

5

High-throughput

0.571

High

189091

SRP19
Signal recognition particle 19 kDa protein

1

2

Small-scale

0.561

High

189170

SMAD1
Mothers against decapentaplegic homolog 1

1

6

Small-scale

0.561

High

189119

BASI
Basigin

2

10

High-throughput

0.558

High

189220

PNKD
Probable thioesterase PNKD

2

5

High-throughput

0.558

High

189135

TPTE
Putative tyrosine-protein phosphatase TPTE

1

8

High-throughput

0.554

High

189071

ZN264
Zinc finger protein 264

2

19

High-throughput

0.553

High

189190

ZN774
Zinc finger protein 774

2

19

High-throughput

0.553

High

189199

ZFP2
Zinc finger protein ZFP2

2

15

High-throughput

0.553

High

189082

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.553

High

189101

ZNF7
Zinc finger protein 7

2

12

High-throughput

0.549

High

189110

TNR5
Tumor necrosis factor receptor superfamily member 5

2

12

High-throughput

0.549

High

189145

EFNB1
Ephrin-B1

2

6

High-throughput

0.549

High

189155

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

20

High-throughput

0.549

High

189247

ZN764
Zinc finger protein 764

2

20

High-throughput

0.549

High

189258

ZN382
Zinc finger protein 382

2

16

High-throughput

0.549

High

138417

BIN1
Myc box-dependent-interacting protein 1

1

1

High-throughput

0.536

High

189070

MTLR
Motilin receptor

1

14

High-throughput

0.536

High

189078

RA51D
DNA repair protein RAD51 homolog 4

1

2

High-throughput

0.536

High

189095

CFTR
Cystic fibrosis transmembrane conductance regulator

1

11

High-throughput

0.536

High

189107

S1PR1
Sphingosine 1-phosphate receptor 1

1

12

High-throughput

0.536

High

189108

FPR1
fMet-Leu-Phe receptor

1

14

High-throughput

0.536

High

189111

STOM
Stomatin

1

9

High-throughput

0.536

High

189113

WEE1
Wee1-like protein kinase

1

9

High-throughput

0.536

High

189125

RANG
Ran-specific GTPase-activating protein

1

16

High-throughput

0.536

High

189126

CBX5
Chromobox protein homolog 5

1

1

Small-scale

0.536

High

189127

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

189153

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

High-throughput

0.536

High

189160

MAP7
Ensconsin

1

11

High-throughput

0.536

High

189178

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.536

High

189197

BCOR
BCL-6 corepressor

1

3

High-throughput

0.536

High

189232

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.536

High

189262

CDX2
Homeobox protein CDX-2

1

3

High-throughput

0.536

High

189264

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

4

High-throughput

0.536

High

189144

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.527

High

189295

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

189276

OSBL5
Oxysterol-binding protein-related protein 5

1

0

High-throughput

0.513

High

189133

ATX1
Ataxin-1

1

4

High-throughput

0.508

High

189164

IMB1
Importin subunit beta-1

1

10

Small-scale

0.501

High

165863

FFAR1
Free fatty acid receptor 1

1

20

High-throughput

0.489

High

182414

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.489

High

189076

TPST2
Protein-tyrosine sulfotransferase 2

1

3

High-throughput

0.489

High

189084

S1PR4
Sphingosine 1-phosphate receptor 4

1

14

High-throughput

0.489

High

189098

ZNF17
Zinc finger protein 17

1

15

High-throughput

0.489

High

189114

V2R
Vasopressin V2 receptor

1

12

High-throughput

0.489

High

189118

APJ
Apelin receptor

1

9

High-throughput

0.489

High

189122

P2RY2
P2Y purinoceptor 2

1

20

High-throughput

0.489

High

189128

AGRE5
Adhesion G protein-coupled receptor E5

1

2

High-throughput

0.489

High

189134

PAR2
Proteinase-activated receptor 2

1

19

High-throughput

0.489

High

189166

P2RY6
P2Y purinoceptor 6

1

20

High-throughput

0.489

High

189177

ZSC23
Zinc finger and SCAN domain-containing protein 23

1

20

High-throughput

0.489

High

189188

ZSC25
Zinc finger and SCAN domain-containing protein 25

1

20

High-throughput

0.489

High

189195

ZN773
Zinc finger protein 773

1

20

High-throughput

0.489

High

189196

BTNL9
Butyrophilin-like protein 9

1

6

High-throughput

0.489

High

189209

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

8

High-throughput

0.489

High

189210

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

20

High-throughput

0.489

High

189219

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

4

High-throughput

0.489

High

189230

ZN784
Zinc finger protein 784

1

20

High-throughput

0.489

High

189233

F174A
Membrane protein FAM174A

1

4

High-throughput

0.489

High

189243

ZN524
Zinc finger protein 524

1

20

High-throughput

0.489

High

189254

ZSC31
Zinc finger and SCAN domain-containing protein 31

1

20

High-throughput

0.489

High

189256

OPALI
Opalin

1

3

High-throughput

0.489

High

189259

SEC62
Translocation protein SEC62

1

2

High-throughput

0.489

High

189277

UN93B
Protein unc-93 homolog B1

1

7

High-throughput

0.489

High

189280

ZN696
Zinc finger protein 696

1

20

High-throughput

0.489

High

189283

ZN287
Zinc finger protein 287

1

13

High-throughput

0.489

High

189296

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

189308

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

20

High-throughput

0.489

High

189310

GPR45
Probable G-protein coupled receptor 45

1

15

High-throughput

0.489

High

189311

NPTN
Neuroplastin

1

9

High-throughput

0.489

High

189123

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.480

High

189073

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

189075

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

189080

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

189081

PCNT
Pericentrin

1

5

High-throughput

0.479

High

189083

SNAI1
Zinc finger protein SNAI1

1

20

High-throughput

0.479

High

189085

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.479

High

189088

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

189093

ARAF
Serine/threonine-protein kinase A-Raf

1

8

High-throughput

0.479

High

189096

T2FB
General transcription factor IIF subunit 2

1

3

High-throughput

0.479

High

189097

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

189104

TFE3
Transcription factor E3

1

1

Small-scale

0.479

High

189109

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.479

High

189112

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

189115

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

189117

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

189120

ZEB1
Zinc finger E-box-binding homeobox 1

1

20

Small-scale

0.479

High

189121

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

189130

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.479

High

189140

RL23A
Large ribosomal subunit protein uL23

1

4

Small-scale

0.479

High

189143

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.479

High

189146

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.479

High

189147

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

189149

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

Small-scale

0.479

High

189152

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.479

High

189157

BIRC3
Baculoviral IAP repeat-containing protein 3

1

8

High-throughput

0.479

High

189159

DCTN1
Dynactin subunit 1

1

3

High-throughput

0.479

High

189161

RBM39
RNA-binding protein 39

1

4

High-throughput

0.479

High

189167

KS6A2
Ribosomal protein S6 kinase alpha-2

1

8

High-throughput

0.479

High

189168

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

189169

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

2

High-throughput

0.479

High

189173

FSCN1
Fascin

1

1

High-throughput

0.479

High

189174

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

189175

DUS5
Dual specificity protein phosphatase 5

1

2

High-throughput

0.479

High

189176

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

189184

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

189185

FTM
Protein fantom

1

14

High-throughput

0.479

High

189187

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

189207

ZN598
E3 ubiquitin-protein ligase ZNF598

1

5

High-throughput

0.479

High

189208

LCA5
Lebercilin

1

6

High-throughput

0.479

High

189214

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.479

High

189228

ZBT38
Zinc finger and BTB domain-containing protein 38

1

20

Small-scale

0.479

High

189229

SERB1
SERPINE1 mRNA-binding protein 1

1

6

High-throughput

0.479

High

189237

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.479

High

189245

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

189252

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

14

High-throughput

0.479

High

189253

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

189261

DNJC2
DnaJ homolog subfamily C member 2

1

5

High-throughput

0.479

High

189265

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

189279

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

189282

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.479

High

189288

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

189291

PD1L1
Programmed cell death 1 ligand 1

1

20

Small-scale

0.479

High

189294

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

189302

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

189303

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

189307

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

189309

YTHD2
YTH domain-containing family protein 2

1

9

High-throughput

0.479

High

189242

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

171361

S27A2
Long-chain fatty acid transport protein 2

1

20

High-throughput

0.445

High

189087

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

189090

ACM4
Muscarinic acetylcholine receptor M4

1

11

High-throughput

0.445

High

189148

ZNF45
Zinc finger protein 45

1

9

High-throughput

0.445

High

189181

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

189189

ZN746
Zinc finger protein 746

1

20

High-throughput

0.445

High

189215

ZNF34
Zinc finger protein 34

1

17

High-throughput

0.445

High

189234

MO2R1
Cell surface glycoprotein CD200 receptor 1

1

2

High-throughput

0.445

High

189238

ZN480
Zinc finger protein 480

1

20

High-throughput

0.445

High

189239

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

20

High-throughput

0.445

High

189266

ZKSC3
Zinc finger protein with KRAB and SCAN domains 3

1

20

High-throughput

0.445

High

189274

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

189301

FZD10
Frizzled-10

1

7

High-throughput

0.445

High

104867

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

189074

KIF1B
Kinesin-like protein KIF1B

1

3

High-throughput

0.437

High

189077

PAGE4
P antigen family member 4

1

1

High-throughput

0.437

High

189079

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

189086

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

189092

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

2

High-throughput

0.437

High

189103

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

12

High-throughput

0.437

High

189106

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

12

High-throughput

0.437

High

189131

5HT6R
5-hydroxytryptamine receptor 6

1

9

Small-scale

0.437

High

189150

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.437

High

189165

HAPR1
HUWE1-associated protein modifying stress responses 1

1

4

High-throughput

0.437

High

189179

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.437

High

189200

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

189201

CE128
Centrosomal protein of 128 kDa

1

6

High-throughput

0.437

High

189205

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

189206

DNJB7
DnaJ homolog subfamily B member 7

1

3

High-throughput

0.437

High

189213

S15A3
Solute carrier family 15 member 3

1

9

High-throughput

0.437

High

189216

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.437

High

189236

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

10

High-throughput

0.437

High

189249

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.437

High

189272

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

189273

YTHD1
YTH domain-containing family protein 1

1

9

High-throughput

0.437

High

189275

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.437

High

189278

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

189300

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

189305

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.437

High

189263

GFI1
Zinc finger protein Gfi-1

1

20

Small-scale

0.417

High

845

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

50443

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.407

High

60166

ZN320
Zinc finger protein 320

1

20

High-throughput

0.407

High

67013

ZN729
Zinc finger protein 729

1

6

High-throughput

0.407

High

70554

ZN850
Zinc finger protein 850

1

6

High-throughput

0.407

High

76465

ZN736
Zinc finger protein 736

1

19

High-throughput

0.407

High

104070

F5H1C8
Solute carrier family 15 member 3

1

9

High-throughput

0.407

High

189072

ZN749
Zinc finger protein 749

1

12

High-throughput

0.407

High

189099

ZNF20
Zinc finger protein 20

1

12

High-throughput

0.407

High

189100

ZNF3
Zinc finger protein 3

1

20

High-throughput

0.407

High

189102

ZNF8
Zinc finger protein 8

1

15

High-throughput

0.407

High

189137

ZN445
Zinc finger protein 445

1

10

High-throughput

0.407

High

189151

ZN543
Zinc finger protein 543

1

11

High-throughput

0.407

High

189156

ZN211
Zinc finger protein 211

1

20

High-throughput

0.407

High

189163

ZN846
Zinc finger protein 846

1

11

High-throughput

0.407

High

189171

ZNF79
Zinc finger protein 79

1

20

High-throughput

0.407

High

189180

ZN484
Zinc finger protein 484

1

8

High-throughput

0.407

High

189186

ZN772
Zinc finger protein 772

1

20

High-throughput

0.407

High

189191

S27A4
Long-chain fatty acid transport protein 4

1

20

High-throughput

0.407

High

189193

ZN549
Zinc finger protein 549

1

17

High-throughput

0.407

High

189194

S27A1
Long-chain fatty acid transport protein 1

1

20

High-throughput

0.407

High

189198

ZN793
Zinc finger protein 793

1

20

High-throughput

0.407

High

189202

ZN534
Zinc finger protein 534

1

12

High-throughput

0.407

High

189203

ZN765
Zinc finger protein 765

1

20

High-throughput

0.407

High

189204

ZN627
Zinc finger protein 627

1

18

High-throughput

0.407

High

189212

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

2

High-throughput

0.407

High

189217

ZN567
Zinc finger protein 567

1

15

High-throughput

0.407

High

189221

ZN561
Zinc finger protein 561

1

20

High-throughput

0.407

High

189223

ZN611
Zinc finger protein 611

1

19

High-throughput

0.407

High

189224

ZN614
Zinc finger protein 614

1

20

High-throughput

0.407

High

189225

ZN557
Zinc finger protein 557

1

20

High-throughput

0.407

High

189226

ZN565
Zinc finger protein 565

1

15

High-throughput

0.407

High

189231

ZN248
Zinc finger protein 248

1

12

High-throughput

0.407

High

189240

ZN566
Zinc finger protein 566

1

20

High-throughput

0.407

High

189246

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

3

High-throughput

0.407

High

189248

ZN419
Zinc finger protein 419

1

20

High-throughput

0.407

High

189250

ZN479
Zinc finger protein 479

1

11

High-throughput

0.407

High

189251

S35E1
Solute carrier family 35 member E1

1

1

High-throughput

0.407

High

189255

ZN578
Zinc finger protein 578

1

17

High-throughput

0.407

High

189257

ZIM3
Zinc finger imprinted 3

1

20

High-throughput

0.407

High

189260

S1PR3
Sphingosine 1-phosphate receptor 3

1

12

High-throughput

0.407

High

189267

ZNF2
Zinc finger protein 2

1

20

High-throughput

0.407

High

189268

ZN577
Zinc finger protein 577

1

20

High-throughput

0.407

High

189271

ZN416
Zinc finger protein 416

1

20

High-throughput

0.407

High

189284

ZN160
Zinc finger protein 160

1

10

High-throughput

0.407

High

189286

ZFP14
Zinc finger protein 14 homolog

1

10

High-throughput

0.407

High

189287

ZN304
Zinc finger protein 304

1

17

High-throughput

0.407

High

189290

ZN446
Zinc finger protein 446

1

20

High-throughput

0.407

High

189299

ZN215
Zinc finger protein 215

1

20

High-throughput

0.407

High

189306

ZN337
Zinc finger protein 337

1

8

High-throughput

0.407

High

189218

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

3

0

High-throughput

0.345

High

189116

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

189235

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

189227

POC5
Centrosomal protein POC5

1

0

High-throughput

0.249

Low

189183

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025