HitPredict

Interactor 1: ALX4 (O35137)
Homeobox protein aristaless-like 4 (ALX-4)
Gene: ALX4

Interactor 2: HXC4 (Q08624)
Homeobox protein Hox-C4 (Homeobox protein Hox-3.5)
Gene: Hoxc4

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0009952 - anterior/posterior pattern specification GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048704 - embryonic skeletal system morphogenesis and 1 others more... GO:0071837 - HMG box domain binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 399 Mm			1 264
+	Mm
		192283 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		HXA10_MOUSE (15-226): 6.78e-37: 136: 30.26
+	Hs
		568043 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		HXB6_HUMAN (8-233): 1.95e-39: 138: 34.80
+	Mm
		192275 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		ALX4_MOUSE (74-262): 5.44e-31: 120: 20.11
+	Hs
		1077278 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		ALX1_HUMAN (39-258): 1.26e-34: 128: 15.70
+	Hs
		1328470 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		ALX4_HUMAN (74-262): 4.32e-31: 120: 19.05
+	Hs
		678782 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		HXD3_HUMAN (114-216): 1.44e-16: 80.5: 46.55
+	Dm
		949988 AL_DROME (159-383): 2.47e-39: 146: 29.03		UBX_DROME (19-217): 5.81e-32: 122: 27.54
+	Hs
		447229 NKX21_HUMAN (24-374): 1.78e-38: 143: 19.83		HXB5_HUMAN (27-231): 2.77e-33: 123: 38.65
+	Hs
		678775 HXD3_HUMAN (8-376): 4.7e-39: 146: 17.82		HXC8_HUMAN (3-224): 7.12e-32: 119: 25.21
+	Hs
		174008 SHOX_HUMAN (191-397): 2.79e-37: 138: 28.50		SHOX_HUMAN (138-218): 8.2e-34: 125: 32.10
+	Mm
		192281 PAX3_MOUSE (138-379): 1.22e-33: 132: 26.98		ALX4_MOUSE (74-262): 5.44e-31: 120: 20.11
+	Dm
		185927 PITX_DROME (178-394): 1.87e-32: 129: 29.22		UBX_DROME (19-217): 5.81e-32: 122: 27.54
+	Mm
		192276 RX_MOUSE (122-395): 1.23e-33: 130: 29.08		ALX4_MOUSE (74-262): 5.44e-31: 120: 20.11
+	Hs
		829821 PITX1_HUMAN (138-393): 1.88e-33: 128: 28.04		HXA1_HUMAN (22-229): 8.85e-32: 121: 29.68
+	Hs
		641327 PAX6_HUMAN (123-379): 1.66e-32: 128: 24.81		HXC8_HUMAN (3-224): 7.12e-32: 119: 25.21
+	Hs
		150341 PITX1_HUMAN (138-393): 1.88e-33: 128: 28.04		CDX4_HUMAN (33-251): 2.19e-30: 116: 23.71
+	Dm
		668243 AL_DROME (159-383): 2.47e-39: 146: 29.03		ABDA_DROME (152-216): 3.52e-21: 94.4: 75.39
+	Dm
		185925 PITX_DROME (178-394): 1.87e-32: 129: 29.22		ABDA_DROME (152-216): 3.52e-21: 94.4: 75.39