HitPredict

Interactor 1: ALX4 (O35137)
Homeobox protein aristaless-like 4 (ALX-4)
Gene: ALX4

Interactor 2: Q8R0B5 (Q8R0B5)
Orthodenticle homeobox 2 (Otx2 protein)
Gene: Otx2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	20211142
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 399 Mm			1 297
+	Mm
		192304 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		Q8VD35_MOUSE (1-297): 3.5e-76: 235: 97.31
+	Mm
		192281 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		PAX3_MOUSE (20-262): 3.82e-38: 142: 27.16
+	Mm
		192277 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		LMX1B_MOUSE (8-237): 6.51e-36: 134: 18.53
+	Mm
		192275 ALX4_MOUSE (1-399): 2.11e-84: 264: 100.00		ALX4_MOUSE (21-245): 2.44e-34: 130: 23.79
+	Hs
		1077278 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		ALX1_HUMAN (26-245): 5.94e-38: 138: 25.56
+	Hs
		1328470 ALX4_HUMAN (1-399): 2.17e-79: 252: 89.78		ALX4_HUMAN (21-245): 3.1e-34: 130: 23.79
+	Bt
		1187205 RAX2_BOVIN (199-328): 4.27e-42: 148: 41.22		CRX_BOVIN (1-297): 1.35e-42: 150: 45.08
+	Hs
		197795 RAX2_HUMAN (197-327): 3.97e-39: 140: 42.42		CRX_HUMAN (1-297): 1.62e-43: 152: 45.40
+	Hs
		656400 PIT1_HUMAN (2-267): 2.75e-39: 143: 13.03		PITX1_HUMAN (40-228): 2.22e-39: 141: 31.68
+	Hs
		678782 HXD3_HUMAN (8-376): 4.7e-39: 146: 17.82		ALX4_HUMAN (21-245): 3.1e-34: 130: 23.79
+	Mm
		936459 PITX1_MOUSE (138-393): 5.24e-33: 127: 27.57		PITX1_MOUSE (40-228): 3.98e-40: 143: 31.68
+	Hs
		941950 PITX2_HUMAN (175-393): 5.69e-32: 125: 28.39		PITX1_HUMAN (40-228): 2.22e-39: 141: 31.68
+	Hs
		641325 PAX6_HUMAN (123-379): 1.66e-32: 128: 24.81		PAX6_HUMAN (7-258): 2.43e-36: 136: 25.00
+	Hs
		174008 SHOX_HUMAN (191-397): 2.79e-37: 138: 28.50		SHOX_HUMAN (35-111): 2.22e-32: 123: 54.55
+	Mm
		192276 RX_MOUSE (122-395): 1.23e-33: 130: 29.08		ALX4_MOUSE (21-245): 2.44e-34: 130: 23.79
+	Mm
		192280 HXD12_MOUSE (22-265): 5.73e-33: 126: 21.72		ALX4_MOUSE (21-245): 2.44e-34: 130: 23.79
+	Hs
		1255791 LMX1A_HUMAN (166-379): 4.9e-31: 123: 17.76		LHX3_HUMAN (47-269): 1.08e-34: 131: 22.13
+	Hs
		1255789 LMX1A_HUMAN (166-379): 4.9e-31: 123: 17.76		LMX1A_HUMAN (10-237): 2.55e-34: 130: 20.78