Protein: SEC22
Protein transport protein SEC22 (Suppressor of loss of YPT1 protein 2)

Gene: SEC22
Organism: Saccharomyces cerevisiae S288C
Interactions: 90
UniProt ID: P22214

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005484 - SNAP receptor activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

646262

SED5
Integral membrane protein SED5

14

20

Small-scale

0.985

High

646214

BOS1
Protein transport protein BOS1

7

1

Small-scale

0.968

High

646224

SSO1
Protein SSO1

6

20

Small-scale

0.937

High

646219

SEC17
Alpha-soluble NSF attachment protein

4

20

Small-scale

0.893

High

646172

SLY1
Protein SLY1

3

12

Small-scale

0.857

High

646239

SSO2
Protein SSO2

3

20

Small-scale

0.850

High

646230

YKT6
Synaptobrevin homolog YKT6

3

8

Small-scale

0.840

High

646235

GOSR1
Golgi SNAP receptor complex member 1

3

20

Small-scale

0.840

High

582413

SEC23
Protein transport protein SEC23

3

1

Small-scale

0.834

High

646245

SEC24
Protein transport protein SEC24

3

1

Small-scale

0.834

High

646276

VAM3
Syntaxin VAM3

3

20

Small-scale

0.833

High

646213

BET1
Protein transport protein BET1

8

17

Small-scale

0.748

High

646251

UFE1
Syntaxin UFE1

5

1

Small-scale

0.714

High

646209

SEC22
Protein transport protein SEC22

1

8

Small-scale

0.710

High

646275

GET3
ATPase GET3

5

0

Small-scale

0.693

High

646281

OSH2
Oxysterol-binding protein homolog 2

1

1

Small-scale

0.691

High

646244

SEC9
Protein transport protein SEC9

3

1

Small-scale

0.665

High

646254

SFT1
Protein transport protein SFT1

3

1

Small-scale

0.655

High

646216

SEC20
Protein transport protein SEC20

3

1

Small-scale

0.650

High

646222

PEP12
Syntaxin PEP12

1

20

Small-scale

0.647

High

646227

SNC2
Synaptobrevin homolog 2

1

12

Small-scale

0.647

High

646266

VTI1
t-SNARE VTI1

1

18

Small-scale

0.647

High

646277

NYV1
Vacuolar v-SNARE NYV1

1

15

Small-scale

0.647

High

633528

SAR1
Small COPII coat GTPase SAR1

2

11

Small-scale

0.621

High

646272

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

2

2

Small-scale

0.619

High

646229

TIP20
Protein transport protein TIP20

2

1

High-throughput

0.611

High

646257

USE1
Protein transport protein USE1

2

1

Small-scale

0.601

High

646242

COG3
Conserved oligomeric Golgi complex subunit 3

2

1

Small-scale

0.586

High

536076

ARF1
ADP-ribosylation factor 1

2

4

Small-scale

0.584

High

616383

SEC18
Vesicular-fusion protein SEC18

2

7

Small-scale

0.584

High

646250

COPB2
Coatomer subunit beta'

2

2

Small-scale

0.584

High

376268

YPT1
GTP-binding protein YPT1

1

4

Small-scale

0.550

High

646234

OSH3
Oxysterol-binding protein homolog 3

1

1

Small-scale

0.536

High

613521

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.518

High

646215

PBN1
Protein PBN1

1

0

High-throughput

0.518

High

646258

YTP1
Protein YTP1

1

0

High-throughput

0.518

High

646279

DGK1
CTP-dependent diacylglycerol kinase 1

1

0

High-throughput

0.518

High

641352

SEC62
Translocation protein SEC62

1

2

High-throughput

0.508

High

631854

SRP54
Signal recognition particle subunit SRP54

1

1

Small-scale

0.501

High

646225

VAM7
Vacuolar morphogenesis protein 7

1

9

Small-scale

0.501

High

646264

TLG1
t-SNARE affecting a late Golgi compartment protein 1

1

20

Small-scale

0.501

High

543839

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.489

High

646278

MDY2
Ubiquitin-like protein MDY2

1

1

Small-scale

0.489

High

646247

MGA2
Protein MGA2

1

0

High-throughput

0.486

High

646248

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.486

High

646265

PEX29
Peroxisomal membrane protein PEX29

1

0

High-throughput

0.486

High

646241

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

5

Small-scale

0.481

High

646211

SEC15
Exocyst complex component SEC15

1

0

Small-scale

0.480

High

564702

ATC1
Calcium-transporting ATPase 1

1

3

High-throughput

0.479

High

646217

COPG
Coatomer subunit gamma

1

1

Small-scale

0.479

High

646220

EMP24
Endosomal protein P24B

1

4

High-throughput

0.479

High

646232

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

646237

ERP2
Protein ERP2

1

5

High-throughput

0.479

High

646238

ERV46
ER-derived vesicles protein ERV46

1

7

High-throughput

0.479

High

646249

COPB
Coatomer subunit beta

1

2

Small-scale

0.479

High

646259

COPA
Coatomer subunit alpha

1

2

Small-scale

0.479

High

646260

TMEDA
Endoplasmic reticulum vesicle protein 25

1

5

High-throughput

0.479

High

646267

SEC13
Protein transport protein SEC13

1

1

High-throughput

0.479

High

646268

ERV41
ER-derived vesicles protein ERV41

1

7

High-throughput

0.479

High

646269

ERP1
Protein ERP1

1

5

High-throughput

0.479

High

646274

ATG9
Autophagy-related protein 9

1

2

High-throughput

0.479

High

646280

ERP4
Protein ERP4

1

6

High-throughput

0.479

High

646283

SEC39
Protein transport protein SEC39

1

1

Small-scale

0.479

High

613836

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.458

High

646210

VPS15
Serine/threonine-protein kinase VPS15

1

0

High-throughput

0.458

High

646212

VPS34
Phosphatidylinositol 3-kinase VPS34

1

0

High-throughput

0.458

High

646226

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.458

High

646231

MNN2
Alpha-1,2-mannosyltransferase MNN2

1

0

Small-scale

0.458

High

646233

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

0

Small-scale

0.458

High

646246

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.458

High

646253

COPD
Coatomer subunit delta

1

0

Small-scale

0.458

High

646256

ATG27
Autophagy-related protein 27

1

0

High-throughput

0.458

High

646263

BECN1
Vacuolar protein sorting-associated protein 30

1

0

High-throughput

0.458

High

646284

SEY1
Protein SEY1

1

0

Small-scale

0.458

High

624836

EXO70
Exocyst complex component EXO70

1

1

Small-scale

0.457

High

646228

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

646240

IMB4
Importin subunit beta-4

1

3

High-throughput

0.437

High

646270

IMB1
Importin subunit beta-1

1

3

High-throughput

0.437

High

646243

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.407

High

646236

CYC2
Cytochrome c mitochondrial import factor CYC2

1

0

High-throughput

0.282

High

646273

GET4
Golgi to ER traffic protein 4

1

0

Small-scale

0.279

Low

646221

SEC6
Exocyst complex component SEC6

1

0

Small-scale

0.261

Low

646223

SEC8
Exocyst complex component SEC8

1

0

Small-scale

0.261

Low

646261

SEC5
Exocyst complex component SEC5

1

0

Small-scale

0.261

Low

646218

CDC3
Cell division control protein 3

1

0

High-throughput

0.251

Low

646252

GZF3
Protein GZF3

1

0

High-throughput

0.251

Low

646255

STB2
Protein STB2

1

0

High-throughput

0.251

Low

646271

ATG23
Autophagy-related protein 23

1

0

High-throughput

0.249

Low

646282

PSF1
DNA replication complex GINS protein PSF1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025