HitPredict

Interactor 1: CASL (O35177)
Enhancer of filamentation 1 (mEF1) (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105)
Gene: Nedd9

Interactor 2: SH2D3 (Q9QZS8)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (SH2 domain-containing Eph receptor-binding protein 1)
Gene: Sh2d3c

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20956287
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CAS_C~RasGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 833 Mm			1 854
+	Hs
		1054782 CASL_HUMAN (1-833): 0: 625: 88.61		SH2D3_HUMAN (23-854): 0: 814: 86.40
+	Hs
		275570 CASL_HUMAN (1-833): 0: 625: 88.61		BCAR3_HUMAN (66-854): 0: 669: 39.81
+	Hs
		275559 BCAR1_HUMAN (1-831): 3.39e-103: 340: 34.22		BCAR3_HUMAN (66-854): 0: 669: 39.81
+	Dm
		1182672 Q7KVE5_DROME (6-829): 1.68e-123: 392: 22.62		Q9VMJ4_DROME (67-845): 0: 568: 26.73
+	Dm
		60037 A4IJ58_DROME (2-829): 3.1e-113: 366: 22.64		Q9VMJ4_DROME (67-845): 0: 568: 26.73
+	Dm
		60027 A4IJ58_DROME (2-829): 3.1e-113: 366: 22.64		Q8T9B3_DROME (67-845): 0: 567: 26.73
+	Hs
		433761 CASL_HUMAN (1-833): 0: 625: 88.61		LYN_HUMAN (95-405): 2.04e-61: 218: 10.03
+	Mm
		192348 CASL_MOUSE (1-833): 0: 643: 100.00		CRK_MOUSE (203-455): 8.8e-55: 193: 19.78
+	Hs
		412193 CASL_HUMAN (1-833): 0: 625: 88.61		FYN_HUMAN (148-392): 9.38e-59: 211: 11.94
+	Hs
		411721 CASL_HUMAN (1-833): 0: 625: 88.61		LCK_HUMAN (125-422): 9e-57: 205: 11.15
+	Hs
		802600 CASL_HUMAN (1-833): 0: 625: 88.61		CRK_HUMAN (203-455): 6.33e-55: 194: 19.78
+	Hs
		802843 CASL_HUMAN (1-833): 0: 625: 88.61		CRKL_HUMAN (214-455): 5.41e-39: 148: 18.96
+	Mm
		403441 BCAR1_MOUSE (1-831): 3.86e-104: 343: 33.52		SRC_MOUSE (77-392): 2.28e-65: 230: 12.79
+	Mm
		639448 BCAR1_MOUSE (1-831): 3.86e-104: 343: 33.52		LYN_MOUSE (98-405): 4.3e-62: 220: 9.82
+	Mm
		763397 BCAR1_MOUSE (1-831): 3.86e-104: 343: 33.52		FYN_MOUSE (148-405): 7.7e-59: 212: 11.74
+	Hs
		412110 BCAR1_HUMAN (1-831): 3.39e-103: 340: 34.22		FYN_HUMAN (148-392): 9.38e-59: 211: 11.94
+	Hs
		433301 BCAR1_HUMAN (1-831): 3.39e-103: 340: 34.22		YES_HUMAN (149-392): 1e-57: 209: 12.12
+	Hs
		411655 BCAR1_HUMAN (1-831): 3.39e-103: 340: 34.22		LCK_HUMAN (125-422): 9e-57: 205: 11.15
+	Mm
		1142189 BCAR1_MOUSE (1-831): 3.86e-104: 343: 33.52		CRK_MOUSE (203-455): 8.8e-55: 193: 19.78
+	Mm
		815091 BCAR1_MOUSE (1-831): 3.86e-104: 343: 33.52		CRKL_MOUSE (214-455): 1.42e-37: 144: 18.59