Protein: AAKB1
5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)

Gene: AAKB1, PRKAB1
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q9Y478

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006633 - fatty acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1095489

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

17

20

Small-scale

0.988

High

930386

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

13

17

Small-scale

0.982

High

930824

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

8

20

High-throughput

0.971

High

1459552

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

7

17

Small-scale

0.966

High

225735

AAKB2
5'-AMP-activated protein kinase subunit beta-2

5

13

High-throughput

0.930

High

1459546

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

5

17

Small-scale

0.928

High

585834

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

3

12

High-throughput

0.855

High

909257

NEK4
Serine/threonine-protein kinase Nek4

2

14

High-throughput

0.811

High

279238

ULK1
Serine/threonine-protein kinase ULK1

2

18

Small-scale

0.802

High

1402693

DCR1C
Protein artemis

4

1

High-throughput

0.694

High

245299

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

2

High-throughput

0.691

High

1401837

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

11

High-throughput

0.691

High

1060314

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

4

1

High-throughput

0.691

High

1161277

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.656

High

1326470

MINK1
Misshapen-like kinase 1

1

0

High-throughput

0.656

High

1233602

LTOR1
Ragulator complex protein LAMTOR1

3

1

High-throughput

0.650

High

988061

GRB2
Growth factor receptor-bound protein 2

2

2

Small-scale

0.631

High

884731

SYHM
Histidine--tRNA ligase, mitochondrial

2

2

High-throughput

0.628

High

1390323

TRI11
E3 ubiquitin-protein ligase TRIM11

2

3

High-throughput

0.628

High

1433429

TBB1
Tubulin beta-1 chain

2

3

High-throughput

0.628

High

1315225

TRM44
Probable tRNA

2

0

High-throughput

0.602

High

592920

CBR1
Carbonyl reductase [NADPH] 1

2

0

High-throughput

0.585

High

1315559

ULK2
Serine/threonine-protein kinase ULK2

1

20

High-throughput

0.575

High

1491336

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

12

High-throughput

0.575

High

1454275

STIM2
Stromal interaction molecule 2

2

1

High-throughput

0.574

High

1462753

HDAC5
Histone deacetylase 5

1

1

Small-scale

0.561

High

1133824

SL9A5
Sodium/hydrogen exchanger 5

2

2

High-throughput

0.549

High

231785

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.536

High

729633

CASPE
Caspase-14

1

3

High-throughput

0.536

High

857209

NSF
Vesicle-fusing ATPase

1

2

High-throughput

0.536

High

1062322

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.536

High

1122381

SCRIB
Protein scribble homolog

1

3

High-throughput

0.536

High

1446145

M1IP1
Mid1-interacting protein 1

1

1

High-throughput

0.536

High

1491000

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.536

High

289737

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

1

High-throughput

0.515

High

568711

GYS1
Glycogen [starch] synthase, muscle

1

3

High-throughput

0.515

High

583036

EZRI
Ezrin

1

2

High-throughput

0.515

High

773311

MYH10
Myosin-10

1

4

High-throughput

0.515

High

212893

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.513

High

997204

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

1461391

PLAT4
Phospholipase A and acyltransferase 4

1

0

High-throughput

0.513

High

214081

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

Small-scale

0.501

High

1094286

ACACA
Acetyl-CoA carboxylase 1

1

1

Small-scale

0.501

High

920915

ACLY
ATP-citrate synthase

1

0

High-throughput

0.493

High

940338

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

1432183

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

0

High-throughput

0.493

High

423521

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

60533

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

3

High-throughput

0.479

High

138349

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

139427

VMA5A
von Willebrand factor A domain-containing protein 5A

1

6

High-throughput

0.479

High

165443

PSA7
Proteasome subunit alpha type-7

1

2

High-throughput

0.479

High

188069

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

1

High-throughput

0.479

High

243381

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

250908

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

251349

CIDEA
Lipid transferase CIDEA

1

1

Small-scale

0.479

High

344047

HS74L
Heat shock 70 kDa protein 4L

1

1

High-throughput

0.479

High

431285

LA
Lupus La protein

1

1

High-throughput

0.479

High

581606

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

3

High-throughput

0.479

High

610518

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

612024

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.479

High

618749

ML12A
Myosin regulatory light chain 12A

1

2

High-throughput

0.479

High

683913

MOES
Moesin

1

2

High-throughput

0.479

High

687744

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

3

High-throughput

0.479

High

724821

METK2
S-adenosylmethionine synthase isoform type-2

1

1

High-throughput

0.479

High

750026

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.479

High

756096

MCM5
DNA replication licensing factor MCM5

1

1

High-throughput

0.479

High

756425

MCM7
DNA replication licensing factor MCM7

1

1

High-throughput

0.479

High

832156

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

4

High-throughput

0.479

High

851450

PRS6B
26S proteasome regulatory subunit 6B

1

1

High-throughput

0.479

High

860428

RS9
Small ribosomal subunit protein uS4

1

2

High-throughput

0.479

High

870021

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

1

High-throughput

0.479

High

901703

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

910341

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.479

High

915227

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.479

High

954933

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.479

High

957251

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

1

High-throughput

0.479

High

957872

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

High-throughput

0.479

High

962665

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

985089

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

996046

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

High-throughput

0.479

High

1026295

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.479

High

1029414

SET
Protein SET

1

2

High-throughput

0.479

High

1100577

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

1109428

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.479

High

1120063

COTL1
Coactosin-like protein

1

1

High-throughput

0.479

High

1136626

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

2

High-throughput

0.479

High

1138807

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1158010

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.479

High

1191506

GRDN
Girdin

1

5

High-throughput

0.479

High

1211562

Q5T081
Regulator of chromosome condensation

1

1

High-throughput

0.479

High

1256233

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1260697

CEP68
Centrosomal protein of 68 kDa

1

1

High-throughput

0.479

High

1337184

ABCF1
ATP-binding cassette sub-family F member 1

1

1

High-throughput

0.479

High

1353512

FNIP1
Folliculin-interacting protein 1

1

1

Small-scale

0.479

High

1372488

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.479

High

1383198

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1399515

IPO9
Importin-9

1

1

High-throughput

0.479

High

1404318

PHX2B
Paired mesoderm homeobox protein 2B

1

2

High-throughput

0.479

High

1404618

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

1414368

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

2

High-throughput

0.479

High

1416071

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

1

High-throughput

0.479

High

1421038

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1430820

ALX4
Homeobox protein aristaless-like 4

1

1

High-throughput

0.479

High

1434315

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1439313

E41L5
Band 4.1-like protein 5

1

2

High-throughput

0.479

High

1447876

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.479

High

1454303

RCC2
Protein RCC2

1

1

High-throughput

0.479

High

1458865

DIC
Mitochondrial dicarboxylate carrier

1

3

High-throughput

0.479

High

1459963

DDX20
Probable ATP-dependent RNA helicase DDX20

1

1

High-throughput

0.479

High

1490458

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

1491137

SF3B6
Splicing factor 3B subunit 6

1

1

High-throughput

0.479

High

322885

MTCL2
Microtubule cross-linking factor 2

1

6

Small-scale

0.470

High

144376

PDXK
Pyridoxal kinase

1

0

High-throughput

0.458

High

224913

BUD23
18S rRNA

1

0

High-throughput

0.458

High

273319

SOCS5
Suppressor of cytokine signaling 5

1

0

High-throughput

0.458

High

286314

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.458

High

360152

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.458

High

361937

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

405364

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

464301

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.458

High

471345

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

487916

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

521066

ACRO
Acrosin

1

0

High-throughput

0.458

High

550539

PABP1
Polyadenylate-binding protein 1

1

0

High-throughput

0.458

High

571014

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

608208

PYRG1
CTP synthase 1

1

0

High-throughput

0.458

High

663464

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

High-throughput

0.458

High

715001

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.458

High

717241

KCY
UMP-CMP kinase

1

0

High-throughput

0.458

High

761066

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

762512

PROF2
Profilin-2

1

0

High-throughput

0.458

High

773699

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.458

High

788828

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.458

High

810480

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

818844

TYRP2
L-dopachrome tautomerase

1

0

High-throughput

0.458

High

853546

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

0

High-throughput

0.458

High

854767

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.458

High

870500

PPCE
Prolyl endopeptidase

1

0

High-throughput

0.458

High

887615

PSB3
Proteasome subunit beta type-3

1

0

High-throughput

0.458

High

892526

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.458

High

894611

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.458

High

895982

F10A1
Hsc70-interacting protein

1

0

High-throughput

0.458

High

896943

DYN2
Dynamin-2

1

0

High-throughput

0.458

High

938637

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.458

High

941311

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

946478

MTPN
Myotrophin

1

0

High-throughput

0.458

High

949470

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

964559

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.458

High

998167

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

0

High-throughput

0.458

High

1015342

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.458

High

1023652

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1030510

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

1032569

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

1033327

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1047153

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

High-throughput

0.458

High

1116467

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.458

High

1149237

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

1150644

TSN
Translin

1

0

High-throughput

0.458

High

1158618

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

1161094

FSCN1
Fascin

1

0

High-throughput

0.458

High

1179402

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.458

High

1198096

FA98B
Protein FAM98B

1

0

High-throughput

0.458

High

1232341

Q6FGG2
VAMP3 protein

1

0

High-throughput

0.458

High

1271697

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.458

High

1323487

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.458

High

1335627

Q8NCK5
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.458

High

1391090

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.458

High

1394822

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.458

High

1400952

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.458

High

1418416

PCGF6
Polycomb group RING finger protein 6

1

0

High-throughput

0.458

High

1420413

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

1437814

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.458

High

1437989

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1454411

BCCIP
BRCA2 and CDKN1A-interacting protein

1

0

High-throughput

0.458

High

1458493

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.458

High

1458626

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.458

High

1460102

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.458

High

1460216

TR112
Multifunctional methyltransferase subunit TRM112-like protein

1

0

High-throughput

0.458

High

1461120

NXT1
NTF2-related export protein 1

1

0

High-throughput

0.458

High

1461123

NUDT5
ADP-sugar pyrophosphatase

1

0

High-throughput

0.458

High

1462685

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

1490536

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.458

High

1491193

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.458

High

1491237

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.458

High

1491292

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

1454392

FNIP2
Folliculin-interacting protein 2

1

1

Small-scale

0.445

High

1491338

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

3

High-throughput

0.445

High

566885

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.437

High

568529

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

717185

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.437

High

829605

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

903836

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.437

High

963151

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.437

High

1142438

PDIA6
Protein disulfide-isomerase A6

1

1

High-throughput

0.437

High

1272082

SYPM
Probable proline--tRNA ligase, mitochondrial

1

3

High-throughput

0.437

High

1385727

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

1446952

RTN4
Reticulon-4

1

4

High-throughput

0.437

High

877730

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.407

High

1063091

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.407

High

1491337

S4A7
Sodium bicarbonate cotransporter 3

1

3

High-throughput

0.407

High

260703

CUTA
Protein CutA

3

0

High-throughput

0.345

High

732953

GASR
Gastrin/cholecystokinin type B receptor

3

0

High-throughput

0.345

High

1230770

HEAT6
HEAT repeat-containing protein 6

2

0

High-throughput

0.328

High

328611

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.282

High

366297

FA10
Coagulation factor X

1

0

High-throughput

0.282

High

1346712

RFESD
Rieske domain-containing protein

1

0

High-throughput

0.279

Low

1461607

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

1462332

PA2GD
Group IID secretory phospholipase A2

1

0

High-throughput

0.279

Low

190524

COPT1
High affinity copper uptake protein 1

1

0

Small-scale

0.261

Low

362080

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.249

Low

935707

MFAP3
Microfibril-associated glycoprotein 3

1

0

High-throughput

0.249

Low

939840

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.249

Low

1050075

PLP2
Proteolipid protein 2

1

0

High-throughput

0.249

Low

1064491

DSC1
Desmocollin-1

1

0

High-throughput

0.249

Low

1191816

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.249

Low

1241631

EBLN2
Endogenous Bornavirus-like nucleoprotein 2

1

0

High-throughput

0.249

Low

1278713

CFA91
Cilia- and flagella-associated protein 91

1

0

High-throughput

0.249

Low

1290258

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

1432848

G3ST2
Galactose-3-O-sulfotransferase 2

1

0

High-throughput

0.249

Low

1438610

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.249

Low

1452110

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low

1452982

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.249

Low

1453661

CNIH4
Protein cornichon homolog 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025