HitPredict

Interactor 1: PSMD4 (O35226)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: UBC (P0CG50)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]
Gene: UBC

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	16810319, 28190767, 29676259, 10921894
Identification Methods	pull down, far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 376 Mm			1 734
+	Hs
		475528 PSMD4_HUMAN (1-363): 0: 522: 96.43		UBC_HUMAN (77-724): 0: 790: 97.22
+	At
		874015 PSMD4_ARATH (1-376): 4.71e-138: 400: 40.59		UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55
+	Sc
		477277 RPN10_YEAST (1-224): 1.61e-98: 295: 49.15		UBI4P_YEAST (381-724): 5.74e-136: 407: 90.99
+	Hs
		874068 PSMD4_HUMAN (1-363): 0: 522: 96.43		RS27A_HUMAN (609-684): 3.67e-42: 152: 100.00
+	Hs
		397868 PSMD4_HUMAN (1-363): 0: 522: 96.43		ISG15_HUMAN (228-380): 5.84e-29: 115: 32.69
+	Hs
		171487 PSMD4_HUMAN (1-363): 0: 522: 96.43		UBD_HUMAN (155-304): 2.52e-28: 113: 32.05
+	Hs
		474970 PSMD4_HUMAN (1-363): 0: 522: 96.43		UBB_HUMAN (1-77): 3.45e-27: 112: 98.70
+	At
		874026 PSMD4_ARATH (1-376): 4.71e-138: 400: 40.59		P4KG4_ARATH (235-423): 6.92e-19: 92.9: 33.16