Protein: INSI2
Insulin-induced gene 2 protein (INSIG-2)

Gene: INSI2, INSIG2
Organism: Homo sapiens
Interactions: 175
UniProt ID: Q9Y5U4

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006641 - triglyceride metabolic process
GO:0006695 - cholesterol biosynthetic process
GO:0008142 - oxysterol binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085410

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

4

3

Small-scale

0.867

High

1408218

RNF5
E3 ubiquitin-protein ligase RNF5

3

4

High-throughput

0.675

High

399753

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

3

Small-scale

0.618

High

800324

INGR2
Interferon gamma receptor 2

2

1

High-throughput

0.606

High

535725

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.584

High

1461270

AMFR
E3 ubiquitin-protein ligase AMFR

2

5

Small-scale

0.584

High

1110944

LAPM5
Lysosomal-associated transmembrane protein 5

2

0

High-throughput

0.580

High

1111762

STIM1
Stromal interaction molecule 1

2

0

High-throughput

0.580

High

1142980

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1191820

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

2

0

High-throughput

0.580

High

1279397

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

1326960

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1347985

ABHD4
(Lyso)-N-acylphosphatidylethanolamine lipase

2

0

High-throughput

0.580

High

1384386

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.580

High

1410445

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.580

High

1491041

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

772426

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

High-throughput

0.578

High

935358

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.561

High

580855

PVR
Poliovirus receptor

2

2

High-throughput

0.553

High

590362

MUC1
Mucin-1

2

1

High-throughput

0.553

High

832664

AQP2
Aquaporin-2

2

2

High-throughput

0.553

High

1109103

AQP6
Aquaporin-6

2

2

High-throughput

0.553

High

1400574

TM237
Transmembrane protein 237

2

1

High-throughput

0.553

High

538181

HSP7C
Heat shock cognate 71 kDa protein

2

2

Small-scale

0.533

High

969104

PRS8
26S proteasome regulatory subunit 8

1

2

Small-scale

0.512

High

1491742

INSI2
Insulin-induced gene 2 protein

1

2

Small-scale

0.501

High

192521

INSI1
Insulin-induced gene 1 protein

1

2

Small-scale

0.479

High

324065

CSTN1
Calsyntenin-1

1

1

High-throughput

0.479

High

338568

SC24B
Protein transport protein Sec24B

1

1

High-throughput

0.479

High

399651

VTNC
Vitronectin

1

1

High-throughput

0.479

High

464482

TSP1
Thrombospondin-1

1

1

High-throughput

0.479

High

470378

INHBA
Inhibin beta A chain

1

1

High-throughput

0.479

High

637812

FLNA
Filamin-A

1

6

High-throughput

0.479

High

699295

CALX
Calnexin

1

1

High-throughput

0.479

High

773703

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.479

High

787907

SRBP1
Sterol regulatory element-binding protein 1

1

4

Small-scale

0.479

High

852897

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

High-throughput

0.479

High

922094

COPA
Coatomer subunit alpha

1

2

High-throughput

0.479

High

994896

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.479

High

1148971

SC23A
Protein transport protein Sec23A

1

1

High-throughput

0.479

High

1155291

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.479

High

1356236

RN139
E3 ubiquitin-protein ligase RNF139

1

5

Small-scale

0.479

High

1366084

PXDN
Peroxidasin homolog

1

1

High-throughput

0.479

High

1386428

FAF2
FAS-associated factor 2

1

1

Small-scale

0.479

High

1398316

RN145
RING finger protein 145

1

5

Small-scale

0.479

High

1462108

UBQL1
Ubiquilin-1

1

2

Small-scale

0.479

High

926873

VMAT1
Chromaffin granule amine transporter

1

0

High-throughput

0.460

High

1428526

ELOV4
Very long chain fatty acid elongase 4

1

0

High-throughput

0.460

High

1490576

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.460

High

158368

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

417875

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

658497

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

873355

COPD
Coatomer subunit delta

1

0

High-throughput

0.458

High

165446

PSA7
Proteasome subunit alpha type-7

1

2

Small-scale

0.457

High

610523

PRS6A
26S proteasome regulatory subunit 6A

1

5

Small-scale

0.457

High

633834

PSB1
Proteasome subunit beta type-1

1

4

Small-scale

0.457

High

386408

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

128094

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

Small-scale

0.437

High

128349

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

Small-scale

0.437

High

162748

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.437

High

224839

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.437

High

320370

PHF14
PHD finger protein 14

1

1

High-throughput

0.437

High

390830

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

437404

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.437

High

447905

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.437

High

456899

ANXA2
Annexin A2

1

1

High-throughput

0.437

High

459929

APT
Adenine phosphoribosyltransferase

1

1

High-throughput

0.437

High

462940

LAMB1
Laminin subunit beta-1

1

2

High-throughput

0.437

High

468960

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.437

High

485545

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.437

High

533110

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.437

High

566234

K1C10
Keratin, type I cytoskeletal 10

1

3

High-throughput

0.437

High

566474

K2C5
Keratin, type II cytoskeletal 5

1

6

High-throughput

0.437

High

568314

PLST
Plastin-3

1

3

High-throughput

0.437

High

590964

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

600970

HSP76
Heat shock 70 kDa protein 6

1

2

Small-scale

0.437

High

623609

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.437

High

651045

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.437

High

673991

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

681249

PSA2
Proteasome subunit alpha type-2

1

3

Small-scale

0.437

High

681751

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.437

High

709317

CCN2
CCN family member 2

1

2

High-throughput

0.437

High

731745

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

761944

HSP74
Heat shock 70 kDa protein 4

1

4

High-throughput

0.437

High

777590

K22E
Keratin, type II cytoskeletal 2 epidermal

1

7

High-throughput

0.437

High

778821

PRS7
26S proteasome regulatory subunit 7

1

2

Small-scale

0.437

High

801600

HSPA9
Stress-70 protein, mitochondrial

1

5

High-throughput

0.437

High

849428

RANG
Ran-specific GTPase-activating protein

1

1

High-throughput

0.437

High

857008

BAG6
Large proline-rich protein BAG6

1

3

Small-scale

0.437

High

881348

FAS
Fatty acid synthase

1

1

High-throughput

0.437

High

885932

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.437

High

887619

PSB3
Proteasome subunit beta type-3

1

2

Small-scale

0.437

High

965957

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

High-throughput

0.437

High

975534

PRS10
26S proteasome regulatory subunit 10B

1

2

Small-scale

0.437

High

993055

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.437

High

993402

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.437

High

996407

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.437

High

997211

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.437

High

1031026

K22O
Keratin, type II cytoskeletal 2 oral

1

6

High-throughput

0.437

High

1057297

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.437

High

1195621

ARI4B
AT-rich interactive domain-containing protein 4B

1

1

High-throughput

0.437

High

1209013

PPR29
Protein phosphatase 1 regulatory subunit 29

1

1

High-throughput

0.437

High

1218580

CCD30
Coiled-coil domain-containing protein 30

1

1

High-throughput

0.437

High

1229160

ZN772
Zinc finger protein 772

1

1

High-throughput

0.437

High

1259651

H2AV
Histone H2A.V

1

1

High-throughput

0.437

High

1288618

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.437

High

1291317

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.437

High

1336343

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.437

High

1359560

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.437

High

1410649

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.437

High

1459904

UBQL2
Ubiquilin-2

1

2

Small-scale

0.437

High

1462393

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.437

High

1490530

RUVB1
RuvB-like 1

1

1

High-throughput

0.437

High

1491743

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.437

High

155627

NEMP1
Nuclear envelope integral membrane protein 1

2

0

High-throughput

0.316

High

258675

G37L1
G-protein coupled receptor 37-like 1

2

0

High-throughput

0.316

High

549924

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

596956

PRLR
Prolactin receptor

2

0

High-throughput

0.316

High

683380

TNR5
Tumor necrosis factor receptor superfamily member 5

2

0

High-throughput

0.316

High

850861

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

0

High-throughput

0.316

High

870813

CXA8
Gap junction alpha-8 protein

2

0

High-throughput

0.316

High

1102472

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

1195282

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.316

High

1207658

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1281211

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

1333525

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.316

High

1347225

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.316

High

1351731

GP152
Probable G-protein coupled receptor 152

2

0

High-throughput

0.316

High

1352561

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.316

High

1353743

MOT10
Monocarboxylate transporter 10

2

0

High-throughput

0.316

High

1383968

TM45B
Transmembrane protein 45B

2

0

High-throughput

0.316

High

1404144

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

2

0

High-throughput

0.316

High

1449830

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

1452341

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.316

High

1403838

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.269

Low

1134188

NTCP
Hepatic sodium/bile acid cotransporter

1

0

High-throughput

0.251

Low

1187609

AR13B
ADP-ribosylation factor-like protein 13B

1

0

High-throughput

0.251

Low

1396418

F210B
Protein FAM210B, mitochondrial

1

0

High-throughput

0.251

Low

1432011

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.251

Low

1447182

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.251

Low

62784

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.249

Low

138354

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

Small-scale

0.249

Low

271201

ASTN2
Astrotactin-2

1

0

High-throughput

0.249

Low

291006

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.249

Low

409147

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.249

Low

446099

ENOA
Alpha-enolase

1

0

Small-scale

0.249

Low

552737

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.249

Low

577935

PLAK
Junction plakoglobin

1

0

Small-scale

0.249

Low

587850

DESP
Desmoplakin

1

0

Small-scale

0.249

Low

608211

PYRG1
CTP synthase 1

1

0

High-throughput

0.249

Low

651898

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.249

Low

680553

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

846551

MATR3
Matrin-3

1

0

High-throughput

0.249

Low

868804

LEG7
Galectin-7

1

0

Small-scale

0.249

Low

933764

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.249

Low

973011

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.249

Low

1040249

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.249

Low

1130686

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

1156498

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.249

Low

1244188

TM10B
tRNA methyltransferase 10 homolog B

1

0

High-throughput

0.249

Low

1248022

AFTIN
Aftiphilin

1

0

High-throughput

0.249

Low

1272228

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.249

Low

1290207

THOC4
THO complex subunit 4

1

0

High-throughput

0.249

Low

1322525

TAGAP
T-cell activation Rho GTPase-activating protein

1

0

High-throughput

0.249

Low

1339574

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.249

Low

1403236

MA7D2
MAP7 domain-containing protein 2

1

0

High-throughput

0.249

Low

1404138

PSB7
Proteasome subunit beta type-7

1

0

High-throughput

0.249

Low

1406106

PHB2
Prohibitin-2

1

0

High-throughput

0.249

Low

1431393

EPN3
Epsin-3

1

0

High-throughput

0.249

Low

1431456

S1PR5
Sphingosine 1-phosphate receptor 5

1

0

High-throughput

0.249

Low

1454190

BTBD7
BTB/POZ domain-containing protein 7

1

0

High-throughput

0.249

Low

1462353

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

Small-scale

0.249

Low

1490483

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.249

Low

1491068

CAB39
Calcium-binding protein 39

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025