HitPredict

Interactor 1: SMAD7 (O35253)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7)
Gene: SMAD7

Interactor 2: DVL1 (P51141)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008013 - beta-catenin binding GO:0035556 - intracellular signal transduction GO:0050821 - protein stabilization
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 426 Mm			1 695
+	Hs
		150650 SMAD7_HUMAN (1-426): 1.17e-170: 486: 98.12		DVL1_HUMAN (1-695): 0: 569: 94.83
+	Mm
		844410 SMAD1_MOUSE (79-424): 6.87e-141: 412: 23.80		DVL1_MOUSE (1-695): 0: 602: 100.00
+	Mm
		844423 SMAD2_MOUSE (82-424): 1.08e-136: 401: 24.29		DVL1_MOUSE (1-695): 0: 602: 100.00
+	Hs
		150693 SMAD3_HUMAN (81-424): 8.58e-142: 413: 25.95		DVL1_HUMAN (1-695): 0: 569: 94.83
+	Hs
		150710 SMAD1_HUMAN (79-424): 8.73e-141: 412: 23.80		DVL1_HUMAN (1-695): 0: 569: 94.83
+	Hs
		150709 SMAD2_HUMAN (82-424): 1.77e-136: 401: 24.46		DVL1_HUMAN (1-695): 0: 569: 94.83
+	Hs
		150947 SMAD3_HUMAN (81-424): 8.58e-142: 413: 25.95		DVL2_HUMAN (3-695): 2.79e-147: 448: 57.75
+	Mm
		844412 SMAD4_MOUSE (54-259): 4.76e-41: 154: 20.74		DVL1_MOUSE (1-695): 0: 602: 100.00
+	Hs
		150701 SMAD4_HUMAN (54-259): 1.52e-41: 156: 22.28		DVL1_HUMAN (1-695): 0: 569: 94.83
+	Hs
		167376 SMAD7_HUMAN (1-426): 1.17e-170: 486: 98.12		PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45
+	Hs
		1078635 SMAD2_HUMAN (82-424): 1.77e-136: 401: 24.46		NEB2_HUMAN (58-423): 2.41e-51: 193: 16.22
+	Hs
		950226 SMAD3_HUMAN (81-424): 8.58e-142: 413: 25.95		PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45
+	Hs
		1078732 SMAD1_HUMAN (79-424): 8.73e-141: 412: 23.80		PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45
+	Hs
		1078579 SMAD2_HUMAN (82-424): 1.77e-136: 401: 24.46		RIMS1_HUMAN (8-655): 1.32e-45: 178: 14.63
+	Hs
		1078596 SMAD2_HUMAN (82-424): 1.77e-136: 401: 24.46		PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45
+	Mm
		1207311 SMAD3_MOUSE (81-424): 8.58e-142: 413: 25.95		MAGI2_MOUSE (117-387): 7.01e-19: 93.7: 11.44
+	Hs
		1035517 SMAD4_HUMAN (54-259): 1.52e-41: 156: 22.28		PARD3_HUMAN (27-541): 1.26e-45: 177: 16.45