Protein: INSI1
Insulin-induced gene 1 protein (INSIG-1)

Gene: INSI1, INSIG1
Organism: Homo sapiens
Interactions: 125
UniProt ID: O15503

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006641 - triglyceride metabolic process
GO:0006695 - cholesterol biosynthetic process
GO:0008142 - oxysterol binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

192487

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

11

3

Small-scale

0.972

High

192419

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

6

3

Small-scale

0.931

High

192517

AMFR
E3 ubiquitin-protein ligase AMFR

6

5

Small-scale

0.726

High

192412

ERLN2
Erlin-2

4

2

Small-scale

0.686

High

192469

TERA
Transitional endoplasmic reticulum ATPase

3

1

Small-scale

0.646

High

192508

FAF2
FAS-associated factor 2

3

1

Small-scale

0.646

High

192504

RN139
E3 ubiquitin-protein ligase RNF139

3

5

Small-scale

0.640

High

192488

SRBP2
Sterol regulatory element-binding protein 2

2

2

Small-scale

0.584

High

192457

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

High-throughput

0.578

High

129921

PGRC1
Membrane-associated progesterone receptor component 1

2

0

Small-scale

0.569

High

192491

AQP6
Aquaporin-6

2

2

High-throughput

0.553

High

192510

TM237
Transmembrane protein 237

2

1

High-throughput

0.553

High

192465

BKRB1
B1 bradykinin receptor

1

0

High-throughput

0.518

High

192414

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

Small-scale

0.515

High

192516

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

Small-scale

0.515

High

192405

INSI1
Insulin-induced gene 1 protein

1

2

Small-scale

0.479

High

192408

ERLN1
Erlin-1

1

1

Small-scale

0.479

High

192413

CSTN1
Calsyntenin-1

1

1

High-throughput

0.479

High

192418

VTNC
Vitronectin

1

1

High-throughput

0.479

High

192425

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.479

High

192430

TSP1
Thrombospondin-1

1

1

High-throughput

0.479

High

192432

INHBA
Inhibin beta A chain

1

1

High-throughput

0.479

High

192446

FLNA
Filamin-A

1

6

High-throughput

0.479

High

192449

CALX
Calnexin

1

1

High-throughput

0.479

High

192452

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

192459

SRBP1
Sterol regulatory element-binding protein 1

1

4

Small-scale

0.479

High

192463

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

High-throughput

0.479

High

192468

COPA
Coatomer subunit alpha

1

2

High-throughput

0.479

High

192478

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.479

High

192494

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.479

High

192507

PXDN
Peroxidasin homolog

1

1

High-throughput

0.479

High

192509

RN145
RING finger protein 145

1

5

Small-scale

0.479

High

192514

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

1

High-throughput

0.479

High

192521

INSI2
Insulin-induced gene 2 protein

1

2

Small-scale

0.479

High

137011

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

0

High-throughput

0.458

High

192410

SOAT2
Sterol O-acyltransferase 2

1

0

Small-scale

0.458

High

192421

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

192422

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.458

High

192441

NCPR
NADPH--cytochrome P450 reductase

1

0

Small-scale

0.458

High

192471

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

192474

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

192490

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

Small-scale

0.458

High

192522

COPG1
Coatomer subunit gamma-1

1

0

High-throughput

0.458

High

165206

PSA7
Proteasome subunit alpha type-7

1

2

Small-scale

0.457

High

192443

PRS6A
26S proteasome regulatory subunit 6A

1

5

Small-scale

0.457

High

142033

CCN1
CCN family member 1

1

2

High-throughput

0.437

High

162392

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.437

High

192406

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.437

High

192407

FLNB
Filamin-B

1

6

High-throughput

0.437

High

192409

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

3

High-throughput

0.437

High

192411

PHF14
PHD finger protein 14

1

1

High-throughput

0.437

High

192415

K1C14
Keratin, type I cytoskeletal 14

1

3

High-throughput

0.437

High

192417

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

192420

K2C1
Keratin, type II cytoskeletal 1

1

6

High-throughput

0.437

High

192423

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.437

High

192424

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.437

High

192426

ANXA2
Annexin A2

1

1

High-throughput

0.437

High

192427

APT
Adenine phosphoribosyltransferase

1

1

High-throughput

0.437

High

192428

LAMB1
Laminin subunit beta-1

1

2

High-throughput

0.437

High

192429

TPM2
Tropomyosin beta chain

1

5

High-throughput

0.437

High

192431

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.437

High

192433

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.437

High

192434

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.437

High

192435

LAMC1
Laminin subunit gamma-1

1

3

High-throughput

0.437

High

192436

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.437

High

192437

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.437

High

192439

K2C5
Keratin, type II cytoskeletal 5

1

6

High-throughput

0.437

High

192440

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

192444

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.437

High

192447

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.437

High

192448

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

192450

CCN2
CCN family member 2

1

2

High-throughput

0.437

High

192454

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

192455

HSP74
Heat shock 70 kDa protein 4

1

4

High-throughput

0.437

High

192460

HSPA9
Stress-70 protein, mitochondrial

1

5

High-throughput

0.437

High

192462

RANG
Ran-specific GTPase-activating protein

1

1

High-throughput

0.437

High

192464

NSF
Vesicle-fusing ATPase

1

2

High-throughput

0.437

High

192466

FAS
Fatty acid synthase

1

1

High-throughput

0.437

High

192467

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.437

High

192473

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

High-throughput

0.437

High

192476

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.437

High

192477

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.437

High

192479

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.437

High

192480

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.437

High

192484

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

1

High-throughput

0.437

High

192485

K22O
Keratin, type II cytoskeletal 2 oral

1

6

High-throughput

0.437

High

192486

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.437

High

192495

ARI4B
AT-rich interactive domain-containing protein 4B

1

1

High-throughput

0.437

High

192497

ZN772
Zinc finger protein 772

1

1

High-throughput

0.437

High

192498

H2AV
Histone H2A.V

1

1

High-throughput

0.437

High

192501

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.437

High

192502

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.437

High

192505

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.437

High

192506

ATX2L
Ataxin-2-like protein

1

1

High-throughput

0.437

High

192511

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

4

High-throughput

0.437

High

192519

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.437

High

192520

RUVB2
RuvB-like 2

1

1

High-throughput

0.437

High

192523

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.437

High

192470

CAD13
Cadherin-13

2

0

High-throughput

0.328

High

192461

5HT2B
5-hydroxytryptamine receptor 2B

1

0

High-throughput

0.282

High

192483

MAP1A
Microtubule-associated protein 1A

1

0

High-throughput

0.279

Low

192496

FOCAD
Focadhesin

1

0

High-throughput

0.279

Low

192513

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.279

Low

192518

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.279

Low

192416

FINC
Fibronectin

1

0

High-throughput

0.249

Low

192438

EF2
Elongation factor 2

1

0

High-throughput

0.249

Low

192442

KCRS
Creatine kinase S-type, mitochondrial

1

0

High-throughput

0.249

Low

192445

PRPS3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.249

Low

192451

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low

192453

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.249

Low

192456

CTNA1
Catenin alpha-1

1

0

High-throughput

0.249

Low

192458

MYH9
Myosin-9

1

0

High-throughput

0.249

Low

192472

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.249

Low

192475

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.249

Low

192481

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.249

Low

192482

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.249

Low

192489

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.249

Low

192492

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.249

Low

192493

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.249

Low

192499

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.249

Low

192500

CAPS2
Calcium-dependent secretion activator 2

1

0

High-throughput

0.249

Low

192512

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

Small-scale

0.249

Low

192515

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

Small-scale

0.249

Low

192503

ZNT7
Zinc transporter 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025