HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: CSF1R (P09581)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10679268
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005654 - nucleoplasm GO:0071345 - cellular response to cytokine stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Mm			1 977
+	Hs
		181766 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		CSF1R_HUMAN (1-977): 0: 698: 74.16
+	Hs
		147375 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		CSF1R_HUMAN (1-977): 0: 698: 74.16
+	Mm
		193336 SOCS1_MOUSE (1-212): 3.72e-50: 163: 100.00		KIT_MOUSE (4-960): 0: 599: 36.11
+	Mm
		403545 SOCS6_MOUSE (67-210): 8.8e-40: 144: 26.06		KIT_MOUSE (4-960): 0: 599: 36.11
+	Hs
		208979 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		PGFRB_HUMAN (22-971): 1.69e-168: 523: 31.96
+	Hs
		181810 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		FLT3_HUMAN (10-952): 2.13e-164: 509: 30.92
+	Mm
		959810 SOCS6_MOUSE (67-210): 8.8e-40: 144: 26.06		FLT3_MOUSE (16-953): 3.14e-161: 501: 30.58
+	Hs
		208976 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		RET_HUMAN (562-930): 9.51e-72: 260: 40.38
+	Hs
		181796 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		FGFR3_HUMAN (84-399): 4.74e-35: 146: 14.09
+	Hs
		208993 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		FGFR4_HUMAN (93-414): 1.23e-34: 144: 16.29
+	Hs
		147391 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		FGFR3_HUMAN (84-399): 4.74e-35: 146: 14.09
+	Hs
		208983 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		FGFR1_HUMAN (32-209): 3.67e-23: 107: 14.22
+	Hs
		181803 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		UFO_HUMAN (14-214): 5.85e-16: 84.8: 13.96
+	Hs
		208998 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		UFO_HUMAN (14-214): 5.85e-16: 84.8: 13.96
+	Hs
		147395 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		UFO_HUMAN (14-214): 5.85e-16: 84.8: 13.96
+	Hs
		499278 SOCS4_HUMAN (13-211): 6.4e-45: 156: 19.81		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		181778 SOCS1_HUMAN (1-212): 2.59e-45: 151: 94.81		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		208982 NCK2_HUMAN (2-176): 2.33e-43: 151: 18.64		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		256847 SOCS5_HUMAN (8-211): 1.48e-41: 149: 19.81		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		147381 SOCS3_HUMAN (40-208): 2.32e-42: 144: 27.27		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73