Protein: HIC2
Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30)

Gene: HIC2
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q96JB3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001817 - regulation of cytokine production
GO:0002682 - regulation of immune system process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060257

ZN169
Zinc finger protein 169

2

20

High-throughput

0.811

High

1146296

E4F1
Transcription factor E4F1

2

20

High-throughput

0.811

High

1285900

ZBT8A
Zinc finger and BTB domain-containing protein 8A

2

18

High-throughput

0.794

High

1032555

CTBP1
C-terminal-binding protein 1

4

6

High-throughput

0.699

High

1055973

ZN460
Zinc finger protein 460

1

18

High-throughput

0.691

High

1055105

HIC1
Hypermethylated in cancer 1 protein

1

20

Small-scale

0.656

High

1294992

HIC2
Hypermethylated in cancer 2 protein

1

18

Small-scale

0.656

High

1294996

CRBN
Protein cereblon

1

4

Small-scale

0.647

High

316962

KLF8
Krueppel-like factor 8

1

19

High-throughput

0.646

High

217045

PRIC3
Prickle planar cell polarity protein 3

2

8

High-throughput

0.628

High

1295001

LZTS2
Leucine zipper putative tumor suppressor 2

2

9

High-throughput

0.628

High

1042288

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1043160

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

1295010

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.618

High

881255

CTBP2
C-terminal-binding protein 2

2

6

High-throughput

0.611

High

1294993

EHMT2
Histone-lysine N-methyltransferase EHMT2

2

5

High-throughput

0.606

High

132024

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.602

High

1295006

YYAP1
YY1-associated protein 1

2

0

High-throughput

0.602

High

1205890

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

2

High-throughput

0.574

High

216307

CALU
Calumenin

2

3

High-throughput

0.558

High

1245738

CEP70
Centrosomal protein of 70 kDa

2

6

High-throughput

0.553

High

380842

S100B
Protein S100-B

1

4

High-throughput

0.536

High

878002

FOXA3
Hepatocyte nuclear factor 3-gamma

1

3

High-throughput

0.536

High

1239017

TEX19
Testis-expressed protein 19

1

2

High-throughput

0.536

High

1295000

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

1295003

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.536

High

1295008

FOXJ2
Forkhead box protein J2

1

2

High-throughput

0.536

High

535912

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

1237064

HORM2
HORMA domain-containing protein 2

1

0

High-throughput

0.513

High

395489

A4
Amyloid-beta precursor protein

1

14

High-throughput

0.501

High

1295013

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

3

High-throughput

0.489

High

1295009

FBLN5
Fibulin-5

1

20

High-throughput

0.489

High

1295011

PNMA2
Paraneoplastic antigen Ma2

1

4

High-throughput

0.489

High

178988

FOXP2
Forkhead box protein P2

1

5

Small-scale

0.479

High

244790

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

319302

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.479

High

998980

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

1140701

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

1183640

RNF44
RING finger protein 44

1

1

Small-scale

0.479

High

1217554

FOXP4
Forkhead box protein P4

1

7

Small-scale

0.479

High

1294994

CIC
Protein capicua homolog

1

12

High-throughput

0.479

High

1294998

FEV
Protein FEV

1

1

High-throughput

0.479

High

1294999

BARD1
BRCA1-associated RING domain protein 1

1

7

High-throughput

0.479

High

1295004

FOXP1
Forkhead box protein P1

1

4

Small-scale

0.479

High

1295012

BRPF3
Bromodomain and PHD finger-containing protein 3

1

5

High-throughput

0.479

High

298723

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

836865

DNLI4
DNA ligase 4

1

0

High-throughput

0.458

High

964399

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1295005

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

402357

JUN
Transcription factor Jun

1

12

High-throughput

0.445

High

1068146

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.438

High

1293909

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1294995

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1294997

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1295007

TBCC1
TBCC domain-containing protein 1

2

0

High-throughput

0.328

High

1295002

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024