HitPredict

Interactor 1: SOCS1 (O35716)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1)
Gene: SOCS1

Interactor 2: JAK2 (Q62120)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.61 1.00 0.786

The method score is based on:

Property Details
Experiments 10679268, 10064597
Identification Methods two hybrid, coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SOCS_box
Common GO terms GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
GO:0019221 - cytokine-mediated signaling pathway
GO:0019901 - protein kinase binding
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 212
Mm

1 1132
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024