Protein: DNM3L
DNA (cytosine-5)-methyltransferase 3-like

Gene: DNM3L, DNMT3L
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9UJW3

Gene Ontology (top 5):
GO:0000792 - heterochromatin
GO:0000794 - condensed nuclear chromosome
GO:0001890 - placenta development
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460711

DNM3A
DNA

7

8

Small-scale

0.970

High

1458297

DNM3B
DNA

5

8

Small-scale

0.924

High

1110165

HDAC1
Histone deacetylase 1

2

4

Small-scale

0.639

High

1017284

H33
Histone H3.3

2

6

Small-scale

0.585

High

959678

MAX
Protein max

1

3

Small-scale

0.561

High

976931

ERR3
Estrogen-related receptor gamma

1

6

Small-scale

0.561

High

1045888

TF65
Transcription factor p65

1

1

Small-scale

0.561

High

1156893

E2F4
Transcription factor E2F4

1

4

Small-scale

0.561

High

685382

PAX6
Paired box protein Pax-6

1

0

Small-scale

0.537

High

1448985

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.518

High

143487

E2F3
Transcription factor E2F3

1

4

Small-scale

0.501

High

211230

HXC11
Homeobox protein Hox-C11

1

3

Small-scale

0.501

High

253419

MAFK
Transcription factor MafK

1

1

Small-scale

0.501

High

282798

E2F6
Transcription factor E2F6

1

4

Small-scale

0.501

High

282955

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

7

Small-scale

0.501

High

354065

HAND1
Heart- and neural crest derivatives-expressed protein 1

1

4

Small-scale

0.501

High

370808

FOS
Protein c-Fos

1

10

Small-scale

0.501

High

397175

ESR1
Estrogen receptor

1

7

Small-scale

0.501

High

404528

GCR
Glucocorticoid receptor

1

7

Small-scale

0.501

High

414801

P53
Cellular tumor antigen p53

1

1

Small-scale

0.501

High

430485

JUN
Transcription factor Jun

1

7

Small-scale

0.501

High

538487

EGR2
E3 SUMO-protein ligase EGR2

1

3

Small-scale

0.501

High

583614

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

7

Small-scale

0.501

High

584051

FOSL1
Fos-related antigen 1

1

10

Small-scale

0.501

High

584162

FOSL2
Fos-related antigen 2

1

7

Small-scale

0.501

High

590507

GATA1
Erythroid transcription factor

1

2

Small-scale

0.501

High

593240

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

Small-scale

0.501

High

603694

JUNB
Transcription factor JunB

1

7

Small-scale

0.501

High

613221

EGR1
Early growth response protein 1

1

3

Small-scale

0.501

High

617119

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

5

Small-scale

0.501

High

617191

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

7

Small-scale

0.501

High

625850

RXRA
Retinoic acid receptor RXR-alpha

1

6

Small-scale

0.501

High

626397

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.501

High

634893

HXA5
Homeobox protein Hox-A5

1

2

Small-scale

0.501

High

905266

MECP2
Methyl-CpG-binding protein 2

1

5

Small-scale

0.501

High

921064

FOSB
Protein FosB

1

9

Small-scale

0.501

High

933962

NR1H2
Oxysterols receptor LXR-beta

1

6

Small-scale

0.501

High

960662

HAND2
Heart- and neural crest derivatives-expressed protein 2

1

2

Small-scale

0.501

High

980508

H4
Histone H4

1

1

Small-scale

0.501

High

1014651

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.501

High

1034704

MEF2A
Myocyte-specific enhancer factor 2A

1

1

Small-scale

0.501

High

1040651

CREM
cAMP-responsive element modulator

1

4

Small-scale

0.501

High

1050841

EGR4
Early growth response protein 4

1

3

Small-scale

0.501

High

1106742

SMAD4
Mothers against decapentaplegic homolog 4

1

2

Small-scale

0.501

High

1127882

HNF4G
Hepatocyte nuclear factor 4-gamma

1

5

Small-scale

0.501

High

1132676

MEF2D
Myocyte-specific enhancer factor 2D

1

1

Small-scale

0.501

High

1134816

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

7

Small-scale

0.501

High

1146298

E2F5
Transcription factor E2F5

1

4

Small-scale

0.501

High

1148268

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

7

Small-scale

0.501

High

1154023

SMAD1
Mothers against decapentaplegic homolog 1

1

2

Small-scale

0.501

High

1160846

NFIL3
Nuclear factor interleukin-3-regulated protein

1

3

Small-scale

0.501

High

1162921

H2A2C
Histone H2A type 2-C

1

2

Small-scale

0.501

High

1163271

H2B2E
Histone H2B type 2-E

1

1

Small-scale

0.501

High

1258970

H32
Histone H3.2

1

6

Small-scale

0.501

High

1367539

ESR2
Estrogen receptor beta

1

7

Small-scale

0.501

High

1371153

DLX4
Homeobox protein DLX-4

1

4

Small-scale

0.501

High

1406115

CDX2
Homeobox protein CDX-2

1

4

Small-scale

0.501

High

1460707

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

9

Small-scale

0.501

High

228390

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

891870

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

219526

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

Small-scale

0.480

High

251284

CRBL2
cAMP-responsive element-binding protein-like 2

1

0

Small-scale

0.480

High

577510

ETS1
Protein C-ets-1

1

0

Small-scale

0.480

High

617261

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.480

High

675717

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.480

High

775479

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.480

High

832337

ID1
DNA-binding protein inhibitor ID-1

1

0

Small-scale

0.480

High

895814

LHX2
LIM/homeobox protein Lhx2

1

0

Small-scale

0.480

High

1005990

GTF2I
General transcription factor II-I

1

0

Small-scale

0.480

High

1061915

TLE5
TLE family member 5

1

0

Small-scale

0.480

High

1118832

TF2H2
General transcription factor IIH subunit 2

1

0

Small-scale

0.480

High

1287936

LDB1
LIM domain-binding protein 1

1

0

Small-scale

0.480

High

1431877

GO45
Golgin-45

1

0

Small-scale

0.480

High

1458468

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.480

High

1460706

DMTF1
Cyclin-D-binding Myb-like transcription factor 1

1

0

Small-scale

0.480

High

1460708

KLF12
Krueppel-like factor 12

1

0

Small-scale

0.480

High

1460710

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

Small-scale

0.480

High

1165405

Q17RL8
HCG2004980, isoform CRA_e

1

1

High-throughput

0.470

High

1260565

PDZD4
PDZ domain-containing protein 4

1

1

High-throughput

0.439

High

1459726

RLP24
Probable ribosome biogenesis protein RLP24

4

0

High-throughput

0.368

High

936138

PAR2
Proteinase-activated receptor 2

1

0

Small-scale

0.261

Low

1031967

NC2B
Protein Dr1

1

0

Small-scale

0.261

Low

1460709

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025