HitPredict

Interactor 1: RING1 (O35730)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)
Gene: RING1

Interactor 2: CBX8 (Q9QXV1)
Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (mPc3)
Gene: CBX8

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16359901
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0003682 - chromatin binding GO:0035102 - PRC1 complex GO:0097027 - ubiquitin-protein transferase activator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 362
+	Hs
		988024 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX8_HUMAN (1-362): 1.14e-93: 286: 87.15
+	Mm
		1321744 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX8_MOUSE (1-362): 7.74e-103: 309: 100.00
+	Mm
		1164651 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		Q6TKP2_MOUSE (1-360): 2.41e-95: 299: 33.91
+	Mm
		1321737 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX6_MOUSE (1-359): 4.06e-86: 268: 34.48
+	Hs
		316019 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX6_HUMAN (1-359): 5.08e-70: 226: 33.42
+	Mm
		193405 RING1_MOUSE (1-406): 8.02e-116: 345: 100.00		CBX2_MOUSE (2-330): 3.34e-58: 198: 22.34
+	Hs
		987972 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX2_HUMAN (2-330): 3.12e-55: 191: 22.62
+	Hs
		316133 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX6_HUMAN (1-359): 5.08e-70: 226: 33.42
+	Mm
		675501 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX2_MOUSE (2-330): 3.34e-58: 198: 22.34
+	Hs
		327842 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX7_HUMAN (1-224): 1.89e-43: 152: 30.83
+	Hs
		123243 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX4_HUMAN (1-322): 8.78e-39: 147: 22.50
+	Mm
		193412 RING1_MOUSE (1-406): 8.02e-116: 345: 100.00		CBX7_MOUSE (1-86): 2.14e-30: 115: 61.63
+	Hs
		327858 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX7_HUMAN (1-224): 1.89e-43: 152: 30.83
+	Mm
		223231 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX4_MOUSE (1-318): 2.91e-39: 148: 24.28
+	Hs
		123308 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX4_HUMAN (1-322): 8.78e-39: 147: 22.50
+	Hs
		987963 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX3_HUMAN (9-104): 3.84e-24: 99.4: 33.33
+	Hs
		949760 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX1_HUMAN (17-76): 8.73e-21: 90.5: 40.00
+	Mm
		1257537 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX7_MOUSE (1-86): 2.14e-30: 115: 61.63
+	Mm
		1321739 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		Q9DCC5_MOUSE (9-104): 3.84e-24: 99.4: 33.33
+	Mm
		613033 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX3_MOUSE (9-104): 4.76e-24: 99.4: 32.29