Protein: APJ
Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)

Gene: APJ, APLNR
Organism: Homo sapiens
Interactions: 231
UniProt ID: P35414

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001568 - blood vessel development
GO:0001570 - vasculogenesis
GO:0001944 - vasculature development
GO:0001947 - heart looping

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720648

AGTR1
Type-1 angiotensin II receptor

2

18

Small-scale

0.789

High

771098

OPRK
Kappa-type opioid receptor

2

18

Small-scale

0.754

High

755525

TTK
Dual specificity protein kinase TTK

2

4

High-throughput

0.726

High

771095

BMR1A
Bone morphogenetic protein receptor type-1A

1

2

High-throughput

0.691

High

771102

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

2

High-throughput

0.691

High

771222

NDC1
Nucleoporin NDC1

3

2

High-throughput

0.662

High

133452

ACATN
Acetyl-coenzyme A transporter 1

2

2

High-throughput

0.628

High

178535

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

2

7

High-throughput

0.628

High

271676

HIP1R
Huntingtin-interacting protein 1-related protein

2

3

High-throughput

0.628

High

419965

B3A2
Anion exchange protein 2

2

2

High-throughput

0.628

High

630464

RAB3B
Ras-related protein Rab-3B

2

3

High-throughput

0.628

High

658642

JAK1
Tyrosine-protein kinase JAK1

2

19

High-throughput

0.628

High

661231

AT2B4
Plasma membrane calcium-transporting ATPase 4

2

20

High-throughput

0.628

High

771111

ARF5
ADP-ribosylation factor 5

2

2

High-throughput

0.628

High

771131

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

2

9

High-throughput

0.628

High

771144

AB17B
Alpha/beta hydrolase domain-containing protein 17B

2

9

High-throughput

0.628

High

771180

T161B
Transmembrane protein 161B

2

3

High-throughput

0.628

High

771185

EXOC6
Exocyst complex component 6

2

3

High-throughput

0.628

High

771193

EDA
Ectodysplasin-A

2

2

High-throughput

0.628

High

771196

EXOC4
Exocyst complex component 4

2

3

High-throughput

0.628

High

771201

COQ8B
Atypical kinase COQ8B, mitochondrial

2

7

High-throughput

0.628

High

771208

EXOC2
Exocyst complex component 2

2

6

High-throughput

0.628

High

771218

S29A1
Equilibrative nucleoside transporter 1

2

2

High-throughput

0.628

High

771247

EXOC1
Exocyst complex component 1

2

2

High-throughput

0.628

High

771259

S53A1
Solute carrier family 53 member 1

2

1

High-throughput

0.628

High

771215

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

3

High-throughput

0.618

High

221439

OX1R
Orexin/Hypocretin receptor type 1

1

18

Small-scale

0.618

High

706013

CXB2
Gap junction beta-2 protein

2

8

High-throughput

0.606

High

771151

TTI2
TELO2-interacting protein 2

3

3

High-throughput

0.604

High

771156

BRAT1
Integrator complex assembly factor BRAT1

3

2

High-throughput

0.604

High

771158

THADA
tRNA

3

3

High-throughput

0.604

High

771168

DAAF5
Dynein axonemal assembly factor 5

3

4

High-throughput

0.604

High

771231

INT2
Integrator complex subunit 2

3

3

High-throughput

0.604

High

771262

IPO11
Importin-11

3

10

High-throughput

0.604

High

771263

XPO7
Exportin-7

3

18

High-throughput

0.604

High

771179

DGLB
Diacylglycerol lipase-beta

2

0

High-throughput

0.602

High

771202

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

2

0

High-throughput

0.602

High

732448

ARRB2
Beta-arrestin-2

1

13

Small-scale

0.590

High

771209

MARK4
MAP/microtubule affinity-regulating kinase 4

1

0

High-throughput

0.584

High

771188

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.578

High

66144

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

2

High-throughput

0.574

High

172513

XPO1
Exportin-1

2

18

High-throughput

0.574

High

173670

BTAF1
TATA-binding protein-associated factor 172

2

6

High-throughput

0.574

High

187475

FANCA
Fanconi anemia group A protein

2

4

High-throughput

0.574

High

230880

ORC5
Origin recognition complex subunit 5

2

2

High-throughput

0.574

High

319457

UFL1
E3 UFM1-protein ligase 1

2

2

High-throughput

0.574

High

360258

COX1
Cytochrome c oxidase subunit 1

2

2

High-throughput

0.574

High

522770

NR2F6
Nuclear receptor subfamily 2 group F member 6

2

5

High-throughput

0.574

High

611012

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

13

High-throughput

0.574

High

665071

COT2
COUP transcription factor 2

2

5

High-throughput

0.574

High

755327

ABCD1
ATP-binding cassette sub-family D member 1

2

11

High-throughput

0.574

High

771104

AK1D1
Aldo-keto reductase family 1 member D1

2

3

High-throughput

0.574

High

771112

BDH
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

2

3

High-throughput

0.574

High

771118

MTX1
Metaxin-1

2

6

High-throughput

0.574

High

771121

COG2
Conserved oligomeric Golgi complex subunit 2

2

2

High-throughput

0.574

High

771132

D19L1
Protein C-mannosyl-transferase DPY19L1

2

3

High-throughput

0.574

High

771135

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

10

High-throughput

0.574

High

771138

MTX3
Metaxin-3

2

6

High-throughput

0.574

High

771142

TM164
Transmembrane protein 164

2

2

High-throughput

0.574

High

771145

ECM29
Proteasome adapter and scaffold protein ECM29

2

10

High-throughput

0.574

High

771146

ATLA3
Atlastin-3

2

7

High-throughput

0.574

High

771147

ACD10
Acyl-CoA dehydrogenase family member 10

2

4

High-throughput

0.574

High

771149

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

2

12

High-throughput

0.574

High

771150

RINT1
RAD50-interacting protein 1

2

4

High-throughput

0.574

High

771152

MZT2B
Mitotic-spindle organizing protein 2B

2

3

High-throughput

0.574

High

771154

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

2

4

High-throughput

0.574

High

771157

HACD2
Very-long-chain

2

2

High-throughput

0.574

High

771164

ADCK1
AarF domain-containing protein kinase 1

2

7

High-throughput

0.574

High

771169

T126B
Complex I assembly factor TMEM126B, mitochondrial

2

3

High-throughput

0.574

High

771172

INT1
Integrator complex subunit 1

2

5

High-throughput

0.574

High

771178

MFSD9
Major facilitator superfamily domain-containing protein 9

2

6

High-throughput

0.574

High

771181

MCU
Calcium uniporter protein, mitochondrial

2

2

High-throughput

0.574

High

771187

SFXN5
Sideroflexin-5

2

7

High-throughput

0.574

High

771197

S2546
Mitochondrial outer membrane protein SLC25A46

2

4

High-throughput

0.574

High

771198

INT12
Integrator complex subunit 12

2

3

High-throughput

0.574

High

771199

GCP3
Gamma-tubulin complex component 3

2

11

High-throughput

0.574

High

771223

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

12

High-throughput

0.574

High

771232

ARV1
Protein ARV1

2

1

High-throughput

0.574

High

771243

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

10

High-throughput

0.574

High

771246

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

2

9

High-throughput

0.574

High

771249

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

2

2

High-throughput

0.574

High

771251

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

2

2

High-throughput

0.574

High

771254

ELOV5
Very long chain fatty acid elongase 5

2

6

High-throughput

0.574

High

771260

CS025
UPF0449 protein C19orf25

2

1

High-throughput

0.574

High

771261

GCP4
Gamma-tubulin complex component 4

2

11

High-throughput

0.574

High

771268

DOLK
Dolichol kinase

2

3

High-throughput

0.574

High

771269

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

2

3

High-throughput

0.574

High

771271

ZDHC9
Palmitoyltransferase ZDHHC9

2

2

High-throughput

0.574

High

771274

PEX16
Peroxisomal membrane protein PEX16

2

2

High-throughput

0.574

High

771125

PDK1
[Pyruvate dehydrogenase

2

3

High-throughput

0.558

High

771105

SC5A3
Sodium/myo-inositol cotransporter

2

2

High-throughput

0.552

High

771096

FDFT
Squalene synthase

2

1

High-throughput

0.549

High

771108

PEX3
Peroxisomal biogenesis factor 3

2

1

High-throughput

0.549

High

771139

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

2

2

High-throughput

0.549

High

771167

CAND1
Cullin-associated NEDD8-dissociated protein 1

2

18

High-throughput

0.549

High

771224

PTSS2
Phosphatidylserine synthase 2

2

7

High-throughput

0.549

High

771236

COG4
Conserved oligomeric Golgi complex subunit 4

2

2

High-throughput

0.549

High

771237

XPO5
Exportin-5

2

17

High-throughput

0.549

High

561921

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.541

High

771266

NDRG4
Protein NDRG4

1

4

High-throughput

0.541

High

170487

RAB7L
Ras-related protein Rab-7L1

1

4

High-throughput

0.536

High

178615

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

3

High-throughput

0.536

High

337695

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.536

High

551961

ADT1
ADP/ATP translocase 1

1

9

High-throughput

0.536

High

609599

LEG3
Galectin-3

1

3

High-throughput

0.536

High

771099

MTOR
Serine/threonine-protein kinase mTOR

1

18

High-throughput

0.536

High

771103

RAB13
Ras-related protein Rab-13

1

2

High-throughput

0.536

High

771106

AT12A
Potassium-transporting ATPase alpha chain 2

1

16

High-throughput

0.536

High

771107

S12A2
Solute carrier family 12 member 2

1

6

High-throughput

0.536

High

771110

RAB38
Ras-related protein Rab-38

1

5

High-throughput

0.536

High

771113

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

4

High-throughput

0.536

High

771117

ATM
Serine-protein kinase ATM

1

15

High-throughput

0.536

High

771128

MSMO1
Methylsterol monooxygenase 1

1

3

High-throughput

0.536

High

771140

TM201
Transmembrane protein 201

1

1

High-throughput

0.536

High

771143

RIF1
Telomere-associated protein RIF1

1

4

High-throughput

0.536

High

771173

NIN
Ninein

1

4

High-throughput

0.536

High

771175

MIGA1
Mitoguardin 1

1

3

High-throughput

0.536

High

771177

TM87A
Transmembrane protein 87A

1

6

High-throughput

0.536

High

771194

GLMN
Glomulin

1

1

High-throughput

0.536

High

771205

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

8

High-throughput

0.536

High

771228

YIPF3
Protein YIPF3

1

5

High-throughput

0.536

High

771230

T126A
Transmembrane protein 126A

1

3

High-throughput

0.536

High

771239

RAB18
Ras-related protein Rab-18

1

5

High-throughput

0.536

High

771253

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

2

High-throughput

0.536

High

771255

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

4

High-throughput

0.536

High

771264

AMFR
E3 ubiquitin-protein ligase AMFR

1

2

High-throughput

0.536

High

771109

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

771116

FOXF1
Forkhead box protein F1

1

0

High-throughput

0.513

High

771203

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

580386

ALDR
Aldo-keto reductase family 1 member B1

1

3

High-throughput

0.494

High

771256

MTCH1
Mitochondrial carrier homolog 1

1

15

High-throughput

0.494

High

189118

IPO8
Importin-8

1

9

High-throughput

0.489

High

211740

ZW10
Centromere/kinetochore protein zw10 homolog

1

4

High-throughput

0.489

High

317442

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

High-throughput

0.489

High

335606

AGM1
Phosphoacetylglucosamine mutase

1

1

High-throughput

0.489

High

506568

GPHRB
Golgi pH regulator B

1

9

High-throughput

0.489

High

664948

ERD21
ER lumen protein-retaining receptor 1

1

3

High-throughput

0.489

High

749594

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

2

High-throughput

0.489

High

771097

VKGC
Vitamin K-dependent gamma-carboxylase

1

1

High-throughput

0.489

High

771114

TAP1
Antigen peptide transporter 1

1

6

High-throughput

0.489

High

771119

TBB3
Tubulin beta-3 chain

1

5

High-throughput

0.489

High

771120

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

2

High-throughput

0.489

High

771123

DPOD3
DNA polymerase delta subunit 3

1

1

High-throughput

0.489

High

771124

OXA1L
Mitochondrial inner membrane protein OXA1L

1

2

High-throughput

0.489

High

771126

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

1

High-throughput

0.489

High

771127

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.489

High

771133

TBB8
Tubulin beta-8 chain

1

5

High-throughput

0.489

High

771137

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

10

High-throughput

0.489

High

771148

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

13

High-throughput

0.489

High

771153

SFXN4
Sideroflexin-4

1

7

High-throughput

0.489

High

771155

INT5
Integrator complex subunit 5

1

2

High-throughput

0.489

High

771159

CERS6
Ceramide synthase 6

1

15

High-throughput

0.489

High

771161

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

10

High-throughput

0.489

High

771165

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

6

High-throughput

0.489

High

771170

MIRO2
Mitochondrial Rho GTPase 2

1

16

High-throughput

0.489

High

771176

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.489

High

771182

NAV1
Neuron navigator 1

1

4

High-throughput

0.489

High

771184

ATLA2
Atlastin-2

1

7

High-throughput

0.489

High

771186

S2540
Mitochondrial glutathione transporter SLC25A40

1

16

High-throughput

0.489

High

771189

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

10

High-throughput

0.489

High

771190

CHPT1
Cholinephosphotransferase 1

1

4

High-throughput

0.489

High

771192

TM9S4
Transmembrane 9 superfamily member 4

1

5

High-throughput

0.489

High

771200

F241B
Protein FAM241B

1

3

High-throughput

0.489

High

771204

RUSF1
RUS family member 1

1

2

High-throughput

0.489

High

771206

MYO19
Unconventional myosin-XIX

1

2

High-throughput

0.489

High

771207

VPS50
Syndetin

1

2

High-throughput

0.489

High

771210

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

8

High-throughput

0.489

High

771213

CP2S1
Cytochrome P450 2S1

1

1

High-throughput

0.489

High

771217

SGMR1
Sigma non-opioid intracellular receptor 1

1

5

High-throughput

0.489

High

771220

GCP2
Gamma-tubulin complex component 2

1

11

High-throughput

0.489

High

771221

S2533
Solute carrier family 25 member 33

1

13

High-throughput

0.489

High

771225

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

1

High-throughput

0.489

High

771226

SFXN3
Sideroflexin-3

1

7

High-throughput

0.489

High

771227

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.489

High

771229

DERL2
Derlin-2

1

1

High-throughput

0.489

High

771234

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

2

High-throughput

0.489

High

771235

SFXN1
Sideroflexin-1

1

7

High-throughput

0.489

High

771238

TPC
Mitochondrial thiamine pyrophosphate carrier

1

13

High-throughput

0.489

High

771244

ECHD1
Ethylmalonyl-CoA decarboxylase

1

4

High-throughput

0.489

High

771245

MDN1
Midasin

1

4

High-throughput

0.489

High

771248

DJC11
DnaJ homolog subfamily C member 11

1

3

High-throughput

0.489

High

771265

KDIS
Kinase D-interacting substrate of 220 kDa

1

2

High-throughput

0.489

High

771267

TMCO1
Calcium load-activated calcium channel

1

3

High-throughput

0.489

High

771270

CDYL
Chromodomain Y-like protein

1

3

High-throughput

0.489

High

771276

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

4

High-throughput

0.489

High

722406

CTR1
High affinity cationic amino acid transporter 1

1

7

High-throughput

0.445

High

771100

PI4KA
Phosphatidylinositol 4-kinase alpha

1

9

High-throughput

0.445

High

771166

GP180
Integral membrane protein GPR180

1

2

High-throughput

0.445

High

771211

XPO6
Exportin-6

1

2

High-throughput

0.445

High

771275

AGRG1
Adhesion G-protein coupled receptor G1

1

10

High-throughput

0.445

High

771134

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.437

High

85094

B7Z207
Protein-serine/threonine kinase

1

3

High-throughput

0.407

High

208027

TTI1
TELO2-interacting protein 1 homolog

1

1

High-throughput

0.407

High

771101

CNDD3
Condensin-2 complex subunit D3

1

4

High-throughput

0.407

High

771136

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.407

High

771141

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

1

High-throughput

0.407

High

771160

UN13D
Protein unc-13 homolog D

1

5

High-throughput

0.407

High

771162

DYM
Dymeclin

1

4

High-throughput

0.407

High

771171

F200C
Protein FAM200C

1

1

High-throughput

0.407

High

771257

STX18
Syntaxin-18

1

1

High-throughput

0.407

High

771258

COPG2
Coatomer subunit gamma-2

1

2

High-throughput

0.407

High

771273

TNPO3
Transportin-3

1

13

High-throughput

0.407

High

193364

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

2

0

High-throughput

0.328

High

397580

NU1M
NADH-ubiquinone oxidoreductase chain 1

2

0

High-throughput

0.328

High

732798

GLPK
Glycerol kinase

2

0

High-throughput

0.328

High

771115

ABD18
Protein ABHD18

2

0

High-throughput

0.328

High

771250

CUED1
CUE domain-containing protein 1

2

0

High-throughput

0.313

High

771163

SETD3
Actin-histidine N-methyltransferase

1

0

High-throughput

0.282

High

129854

GET1
Guided entry of tail-anchored proteins factor 1

1

0

High-throughput

0.279

Low

166876

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.279

Low

219927

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.279

Low

276950

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.279

Low

662774

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

771129

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

771130

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.279

Low

771174

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

0

High-throughput

0.279

Low

771191

THEM6
Protein THEM6

1

0

High-throughput

0.279

Low

771195

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

771212

TM209
Transmembrane protein 209

1

0

High-throughput

0.279

Low

771214

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.279

Low

771219

MIC25
MICOS complex subunit MIC25

1

0

High-throughput

0.279

Low

771240

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

771241

PYRG2
CTP synthase 2

1

0

High-throughput

0.279

Low

771242

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

771252

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.279

Low

771272

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.279

Low

771233

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

720558

TSPO
Translocator protein

1

0

High-throughput

0.232

Low

771122

NC2A
Dr1-associated corepressor

1

0

High-throughput

0.232

Low

771183

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low

771216

TI17A
Mitochondrial import inner membrane translocase subunit Tim17-A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025