HitPredict

Interactor 1: HIF1A (O35800)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha)
Gene: HIF1A

Interactor 2: VHL (Q64259)
von Hippel-Lindau disease tumor suppressor (pVHL)
Gene: VHL

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 15010533, 19950214
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HIF-1~VHL
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001525 - angiogenesis
GO:0001666 - response to hypoxia
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 12 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 825
Rn

1 185
+ Mm
+ Hs
+ Hs
+ Rn
+ Mm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024