Protein: APBB2
Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1)

Gene: APBB2
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q92870

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001540 - amyloid-beta binding
GO:0001764 - neuron migration
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

422770

A4
Amyloid-beta precursor protein

10

16

Small-scale

0.974

High

1055338

APLP2
Amyloid beta precursor like protein 2

5

15

Small-scale

0.919

High

907324

APLP1
Amyloid beta precursor like protein 1

4

13

High-throughput

0.892

High

127154

APBB1
Amyloid beta precursor protein binding family B member 1

3

3

High-throughput

0.861

High

247147

TBCD4
TBC1 domain family member 4

3

1

High-throughput

0.861

High

1369637

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

0

High-throughput

0.816

High

363669

EGFR
Epidermal growth factor receptor

4

6

High-throughput

0.699

High

1047237

ATP7A
Copper-transporting ATPase 1

4

3

High-throughput

0.691

High

1369646

TBD2B
TBC1 domain family member 2B

4

2

High-throughput

0.691

High

1369627

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

3

1

High-throughput

0.667

High

1369642

FMN2
Formin-2

3

2

High-throughput

0.667

High

911855

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

4

0

High-throughput

0.661

High

1366490

AKAP1
A-kinase anchor protein 1, mitochondrial

4

0

High-throughput

0.661

High

1369603

APBB2
Amyloid beta precursor protein binding family B member 2

1

3

Small-scale

0.647

High

1369643

WWOX
WW domain-containing oxidoreductase

1

0

Small-scale

0.645

High

537638

HSP7C
Heat shock cognate 71 kDa protein

3

0

High-throughput

0.638

High

1369621

APOL2
Apolipoprotein L2

3

0

High-throughput

0.638

High

1369629

LDH6B
L-lactate dehydrogenase A-like 6B

3

0

High-throughput

0.638

High

1369636

WDR41
WD repeat-containing protein 41

3

0

High-throughput

0.638

High

1004153

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.618

High

1217691

SYDE2
Rho GTPase-activating protein SYDE2

3

3

High-throughput

0.609

High

1187210

CC50B
Cell cycle control protein 50B

2

0

High-throughput

0.602

High

976467

RB11A
Ras-related protein Rab-11A

2

2

High-throughput

0.584

High

853721

MK08
Mitogen-activated protein kinase 8

1

2

Small-scale

0.561

High

1048272

HGFA
Hepatocyte growth factor activator serine protease

2

2

High-throughput

0.549

High

584572

VAV
Proto-oncogene vav

1

1

High-throughput

0.536

High

249326

DLX3
Homeobox protein DLX-3

1

1

High-throughput

0.515

High

440660

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.515

High

605768

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.515

High

893723

MEOX1
Homeobox protein MOX-1

1

1

High-throughput

0.515

High

946025

VSX2
Visual system homeobox 2

1

1

High-throughput

0.515

High

1071179

ARL16
ADP-ribosylation factor-like protein 16

1

6

High-throughput

0.515

High

1206996

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

2

High-throughput

0.515

High

1239367

ESRP1
Epithelial splicing regulatory protein 1

1

2

High-throughput

0.515

High

1248167

SAS6
Spindle assembly abnormal protein 6 homolog

1

2

High-throughput

0.515

High

1279522

Q7Z637
protein-tyrosine-phosphatase

1

1

High-throughput

0.515

High

1328648

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.515

High

1369604

HDA10
Polyamine deacetylase HDAC10

1

1

High-throughput

0.515

High

1369605

OPTN
Optineurin

1

3

High-throughput

0.515

High

1369617

KCD15
BTB/POZ domain-containing protein KCTD15

1

1

High-throughput

0.515

High

1369624

SOX7
Transcription factor SOX-7

1

1

High-throughput

0.515

High

1369630

RAB6C
Ras-related protein Rab-6C

1

5

High-throughput

0.515

High

66938

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.513

High

615192

PACA
Pituitary adenylate cyclase-activating polypeptide

1

0

High-throughput

0.513

High

1009158

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

0

High-throughput

0.513

High

414338

P53
Cellular tumor antigen p53

1

1

Small-scale

0.501

High

48300

E2F8
Transcription factor E2F8

1

0

High-throughput

0.493

High

62335

A4FUJ8
MKL1 protein

1

0

High-throughput

0.493

High

85131

B7Z3E8
cDNA FLJ51208

1

0

High-throughput

0.493

High

188698

BIRC5
Baculoviral IAP repeat-containing protein 5

1

0

High-throughput

0.493

High

193804

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.493

High

211657

ZNHI1
Zinc finger HIT domain-containing protein 1

1

0

High-throughput

0.493

High

217169

MS18B
Protein Mis18-beta

1

0

High-throughput

0.493

High

217281

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.493

High

282286

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

296541

STAM2
Signal transducing adapter molecule 2

1

0

High-throughput

0.493

High

297665

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.493

High

341460

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.493

High

617178

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

0

High-throughput

0.493

High

634862

HXA5
Homeobox protein Hox-A5

1

0

High-throughput

0.493

High

643535

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.493

High

666879

CCNC
Cyclin-C

1

0

High-throughput

0.493

High

852818

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.493

High

989071

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.493

High

1005624

PITX1
Pituitary homeobox 1

1

0

High-throughput

0.493

High

1040877

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.493

High

1093675

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.493

High

1094505

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

High-throughput

0.493

High

1103923

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

0

High-throughput

0.493

High

1110907

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

High-throughput

0.493

High

1160980

NRF1
Nuclear respiratory factor 1

1

0

High-throughput

0.493

High

1229482

NAIF1
Nuclear apoptosis-inducing factor 1

1

0

High-throughput

0.493

High

1231856

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.493

High

1242686

KLC3
Kinesin light chain 3

1

0

High-throughput

0.493

High

1244927

FOXR1
Forkhead box protein R1

1

0

High-throughput

0.493

High

1250566

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

High-throughput

0.493

High

1259219

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

1

0

High-throughput

0.493

High

1307988

SPA2L
Spermatogenesis-associated protein 2-like protein

1

0

High-throughput

0.493

High

1329720

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.493

High

1330850

SMIP4
Sperm-associated microtubule inner protein 4

1

0

High-throughput

0.493

High

1330997

ZN366
Zinc finger protein 366

1

0

High-throughput

0.493

High

1333560

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

0

High-throughput

0.493

High

1357353

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.493

High

1368261

DPF1
Zinc finger protein neuro-d4

1

0

High-throughput

0.493

High

1369606

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.493

High

1369609

PP16A
Protein phosphatase 1 regulatory subunit 16A

1

0

High-throughput

0.493

High

1369610

ANCHR
Abscission/NoCut checkpoint regulator

1

0

High-throughput

0.493

High

1369611

BMF
Bcl-2-modifying factor

1

0

High-throughput

0.493

High

1369613

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

1369614

TIGD1
Tigger transposable element-derived protein 1

1

0

High-throughput

0.493

High

1369615

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.493

High

1369618

EYA3
Protein phosphatase EYA3

1

0

High-throughput

0.493

High

1369622

ST4A1
Sulfotransferase 4A1

1

0

High-throughput

0.493

High

1369625

BBLN
Bublin coiled-coil protein

1

0

High-throughput

0.493

High

1369638

NXT2
NTF2-related export protein 2

1

0

High-throughput

0.493

High

1369645

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.493

High

1369647

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.493

High

1369648

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.493

High

1369649

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.493

High

1257028

SYDE1
Rho GTPase-activating protein SYDE1

1

3

High-throughput

0.489

High

1306997

WFDC8
WAP four-disulfide core domain protein 8

1

12

High-throughput

0.489

High

626310

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

Small-scale

0.480

High

164408

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

189757

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

226160

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

250740

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.479

High

540605

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

541622

FGFR1
Fibroblast growth factor receptor 1

1

6

High-throughput

0.479

High

560471

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

594068

NCK1
SH2/SH3 adapter protein NCK1

1

3

High-throughput

0.479

High

604140

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

630601

RAB3B
Ras-related protein Rab-3B

1

4

High-throughput

0.479

High

631390

RAB5A
Ras-related protein Rab-5A

1

4

High-throughput

0.479

High

641228

FGFR2
Fibroblast growth factor receptor 2

1

5

High-throughput

0.479

High

648618

FGFR4
Fibroblast growth factor receptor 4

1

6

High-throughput

0.479

High

710409

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.479

High

901452

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.479

High

945063

RAB25
Ras-related protein Rab-25

1

2

High-throughput

0.479

High

951318

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

1041213

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1058568

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

1087229

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

1369619

SORT
Sortilin

1

1

High-throughput

0.479

High

1369623

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

2

High-throughput

0.479

High

1369635

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1369644

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

137340

ELL2
RNA polymerase II elongation factor ELL2

1

1

High-throughput

0.470

High

1253642

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.470

High

1279573

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

4

High-throughput

0.470

High

1361424

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

1

High-throughput

0.470

High

1150556

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.460

High

1259396

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

1276264

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1330891

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

1369633

GAN
Gigaxonin

1

0

High-throughput

0.458

High

1369641

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

898127

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

1

High-throughput

0.445

High

1307347

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

2

High-throughput

0.445

High

1369612

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.445

High

1369616

FRMD6
FERM domain-containing protein 6

1

1

High-throughput

0.445

High

843830

HD
Huntingtin

1

0

High-throughput

0.438

High

139952

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

901985

RAB9A
Ras-related protein Rab-9A

1

7

High-throughput

0.437

High

1031481

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

1145049

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.437

High

1233398

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1322929

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.437

High

1369628

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.437

High

1369639

SAR1A
Small COPII coat GTPase SAR1A

1

4

High-throughput

0.437

High

160739

TOR1A
Torsin-1A

1

0

High-throughput

0.426

High

219206

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.426

High

831168

CCNF
Cyclin-F

1

0

High-throughput

0.426

High

1093561

TRDN
Triadin

1

0

High-throughput

0.426

High

335365

CCN6
Cellular communication network factor 6

3

0

High-throughput

0.347

High

1369632

OSBL2
Oxysterol-binding protein-related protein 2

3

0

High-throughput

0.347

High

548083

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

837376

ASIP
Agouti-signaling protein

1

0

High-throughput

0.279

Low

69711

A8K878
cDNA FLJ77177, highly similar to Homo sapiens arginine-rich, mutated in early stage tumors

1

0

High-throughput

0.268

Low

185224

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.268

Low

914158

HXK3
Hexokinase-3

1

0

High-throughput

0.268

Low

1200211

Q53NU3
cDNA, FLJ92284

1

0

High-throughput

0.268

Low

1220550

VCF2
Protein VCF2

1

0

High-throughput

0.268

Low

1243607

AB17C
Alpha/beta hydrolase domain-containing protein 17C

1

0

High-throughput

0.268

Low

1244514

Q6PHZ7
NR2C2 protein

1

0

High-throughput

0.268

Low

1251017

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.268

Low

1253293

Q6ZP95
cDNA FLJ26194 fis, clone ADG06758

1

0

High-throughput

0.268

Low

1273069

Q7L8T7
cDNA FLJ40572 fis, clone THYMU2006170

1

0

High-throughput

0.268

Low

1280004

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

1307006

KR191
Keratin-associated protein 19-1

1

0

High-throughput

0.268

Low

1307082

KRA81
Keratin-associated protein 8-1

1

0

High-throughput

0.268

Low

1315087

SHLD1
Shieldin complex subunit 1

1

0

High-throughput

0.268

Low

1322183

CF218
Putative uncharacterized protein encoded by LINC00518

1

0

High-throughput

0.268

Low

1349416

ENKUR
Enkurin

1

0

High-throughput

0.268

Low

1350849

HUMMR
Protein MGARP

1

0

High-throughput

0.268

Low

1369607

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.268

Low

1369608

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.268

Low

1369631

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.268

Low

1369634

Q9H669
cDNA: FLJ22558 fis, clone HSI01557

1

0

High-throughput

0.268

Low

1369640

S6A13
Sodium- and chloride-dependent GABA transporter 2

1

0

High-throughput

0.268

Low

1369650

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.268

Low

1227191

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1369620

METH
Methionine synthase

1

0

High-throughput

0.232

Low

1369626

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025