HitPredict

Interactor 1: PRP22 (O42643)
Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 (EC 3.6.4.13)
Gene: PRP22

Interactor 2: CEF1 (P39964)
Pre-mRNA-splicing factor cdc5 (Cell division control protein 5)
Gene: cdc5

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15755920, 24014766, 11884590
Identification Methods	affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0071014 - post-mRNA release spliceosomal complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1168 Sp			1 757
+	Hs
		1055461 DHX8_HUMAN (2-1162): 0: 981: 51.07		CDC5L_HUMAN (2-753): 3.79e-179: 534: 37.01
+	Sp
		765721 PRP16_SCHPO (12-1132): 0: 785: 35.89		CEF1_SCHPO (1-757): 0: 574: 100.00
+	Sp
		765714 CDC28_SCHPO (100-1145): 0: 753: 35.82		CEF1_SCHPO (1-757): 0: 574: 100.00
+	Hs
		1268330 PRP16_HUMAN (157-1143): 0: 786: 38.08		CDC5L_HUMAN (2-753): 3.79e-179: 534: 37.01
+	Hs
		224835 DHX16_HUMAN (285-1145): 0: 744: 42.20		CDC5L_HUMAN (2-753): 3.79e-179: 534: 37.01
+	Sp
		194925 DHX15_SCHPO (433-1154): 0: 694: 47.08		CEF1_SCHPO (1-757): 0: 574: 100.00
+	Hs
		1220267 DHX40_HUMAN (463-1166): 0: 603: 39.30		CDC5L_HUMAN (2-753): 3.79e-179: 534: 37.01
+	Sc
		622337 PRP22_YEAST (10-1165): 0: 833: 44.90		CEF1_YEAST (2-581): 4.25e-88: 290: 29.10
+	Sc
		859420 PRP43_YEAST (420-1150): 0: 687: 46.08		CEF1_YEAST (2-581): 4.25e-88: 290: 29.10
+	Sc
		554244 PRP16_YEAST (281-1138): 0: 636: 37.60		CEF1_YEAST (2-581): 4.25e-88: 290: 29.10
+	Sc
		589450 PRP2_YEAST (293-1129): 0: 599: 36.37		CEF1_YEAST (2-581): 4.25e-88: 290: 29.10