HitPredict

Interactor 1: DHX15 (O43143)
ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)
Gene: DHX15

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25192599, 29884807, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 795 Hs			1 526
+	Hs
		195503 DHX15_HUMAN (1-795): 0: 856: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		195574 DHX15_HUMAN (1-795): 0: 856: 100.00		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		1055514 DHX8_HUMAN (16-783): 0: 757: 45.46		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Sc
		376861 PRP43_YEAST (47-792): 0: 740: 59.89		PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49
+	Hs
		1332150 DHX35_HUMAN (90-782): 0: 668: 41.75		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		994270 DHX9_HUMAN (3-764): 0: 599: 23.31		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		726770 DHX9_HUMAN (3-764): 0: 599: 23.31		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		727033 DHX36_HUMAN (17-773): 0: 598: 25.32		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		967130 DHX9_HUMAN (3-764): 0: 599: 23.31		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		994398 DHX9_HUMAN (3-764): 0: 599: 23.31		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		994418 DHX9_HUMAN (3-764): 0: 599: 23.31		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35