HitPredict

Interactor 1: ASAP2 (O43150)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)
Gene: ASAP2

Interactor 2: Q5JPT6 (Q5JPT6)
GIG10 (Migration-inducing gene 18 protein) (cDNA, FLJ93821, Homo sapiens SH3-domain kinase binding protein 1 (SH3KBP1), mRNA)
Gene: Q5JPT6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_9, PH~SH3_9, SH3_9~SH3_9
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1006 Hs			1 665
+	Hs
		195804 ASAP2_HUMAN (1-1006): 0: 661: 100.00		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		195783 ASAP2_HUMAN (1-1006): 0: 661: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		195791 ASAP2_HUMAN (1-1006): 0: 661: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		195795 ASAP2_HUMAN (1-1006): 0: 661: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		195770 ASAP2_HUMAN (1-1006): 0: 661: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		557696 ACAP1_HUMAN (23-678): 3.93e-128: 407: 19.97		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924582 ACAP1_HUMAN (23-678): 3.93e-128: 407: 19.97		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		1136563 AGAP1_HUMAN (136-646): 6.55e-94: 319: 17.69		SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72
+	Hs
		1285175 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		1064304 ACAP1_HUMAN (23-678): 3.93e-128: 407: 19.97		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Dm
		1368053 RHGF_DROME (23-1004): 5.18e-83: 292: 12.03		Q9VIN1_DROME (2-656): 1.03e-49: 186: 16.50
+	Dm
		1279243 GIT_DROME (394-958): 1.49e-61: 225: 19.72		Q9VIN1_DROME (2-656): 1.03e-49: 186: 16.50
+	Mm
		1112583 AGAP2_MOUSE (136-646): 5.93e-79: 282: 18.39		SRBS1_MOUSE (3-155): 1.1e-13: 77: 34.15
+	Mm
		1112566 AGAP2_MOUSE (136-646): 5.93e-79: 282: 18.39		SRBS2_MOUSE (3-155): 3.32e-11: 68.9: 30.86
+	Hs
		557775 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924798 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		209145 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		235575 ARAP1_HUMAN (362-559): 1.21e-18: 94: 31.03		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		275240 ASAP1_HUMAN (749-1006): 4.17e-17: 88.8: 26.74		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		209187 ASAP1_HUMAN (749-1006): 4.17e-17: 88.8: 26.74		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77