Protein: FOXO
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16)

Gene: FOXO, daf-16
Organism: Caenorhabditis elegans
Interactions: 67
UniProt ID: O16850

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002119 - nematode larval development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

195812

14332
14-3-3-like protein 2

4

20

Small-scale

0.677

High

195802

AKT1
Serine/threonine-protein kinase akt-1

2

11

Small-scale

0.657

High

195816

SGK1
Serine/threonine-protein kinase sgk-1

2

13

Small-scale

0.657

High

195832

AKT2
Serine/threonine-protein kinase akt-2

2

12

Small-scale

0.657

High

195801

PHA4
Defective pharyngeal development protein 4

1

20

High-throughput

0.656

High

195793

14331
14-3-3-like protein 1

3

20

Small-scale

0.640

High

195814

SIR2
NAD-dependent protein deacetylase sir-2.1

2

13

Small-scale

0.612

High

195792

CBP1
Protein cbp-1

2

20

Small-scale

0.594

High

195784

RLE1
Regulation of longevity by E3 ubiquitin-protein ligase

1

2

Small-scale

0.561

High

195818

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

Small-scale

0.561

High

195820

JNK1
Stress-activated protein kinase jnk-1

1

4

Small-scale

0.561

High

195826

Q9N5V3
Importin N-terminal domain-containing protein

1

2

High-throughput

0.560

High

195794

SMA3
Dwarfin sma-3

1

19

Small-scale

0.552

High

195798

SMA2
Dwarfin sma-2

1

19

Small-scale

0.552

High

195786

KCC2D
Calcium/calmodulin-dependent protein kinase type II

1

0

Small-scale

0.537

High

195799

EGL27
Egg-laying defective protein 27

1

12

Small-scale

0.536

High

195783

RN113
Probable E3 ubiquitin-protein ligase rnf113

1

0

High-throughput

0.518

High

63454

SIN3
Paired amphipathic helix protein sin-3

1

2

High-throughput

0.508

High

111451

PAX3H
Paired box protein 3 homolog

1

20

High-throughput

0.508

High

195785

KLF2
Kruppel-like factor 2

1

20

High-throughput

0.508

High

195805

NHR43
Nuclear hormone receptor family member nhr-43

1

20

High-throughput

0.508

High

195808

ZTF2
Zinc finger protein ztf-2

1

5

High-throughput

0.508

High

195817

NU301
Nucleosome-remodeling factor subunit NURF301-like

1

20

High-throughput

0.508

High

195827

TBX39
Putative T-box protein 39

1

10

High-throughput

0.508

High

195833

Q9XVN4
Homeobox domain-containing protein

1

20

High-throughput

0.508

High

195834

Q9XWK6
Regulator of microtubule dynamics protein 1

1

1

High-throughput

0.508

High

195823

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

Small-scale

0.501

High

195797

PFD6
Probable prefoldin subunit 6

1

0

Small-scale

0.493

High

195815

Q22826
Fork-head domain-containing protein

1

0

High-throughput

0.486

High

195828

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.486

High

115602

H2KZU3
NR LBD domain-containing protein

1

20

High-throughput

0.481

High

145675

O02174
C3H1-type domain-containing protein

1

1

High-throughput

0.481

High

195819

Q86PI8
Nuclear receptor NHR-114

1

20

High-throughput

0.481

High

110332

HCF1
Host cell factor homolog hcf-1

1

4

Small-scale

0.479

High

116565

H8ESF3
SWI/SNF complex subunit SMARCC2

1

4

Small-scale

0.479

High

116617

H9G2X3
Serine/threonine protein phosphatase 2A regulatory subunit

1

1

Small-scale

0.479

High

195787

O62332
Importin N-terminal domain-containing protein

1

4

Small-scale

0.479

High

195789

MLR2
Myosin regulatory light chain 2

1

2

Small-scale

0.479

High

195790

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.479

High

195803

RCC1
Regulator of chromosome condensation

1

8

Small-scale

0.479

High

195806

BAR1
Beta-catenin/armadillo-related protein 1

1

12

Small-scale

0.479

High

195807

Q19007
Nucleosome assembly protein 1-like 1

1

2

Small-scale

0.479

High

195809

RFA1
Probable replication factor A 73 kDa subunit

1

1

Small-scale

0.479

High

195810

VRK1
Serine/threonine-protein kinase VRK1

1

13

Small-scale

0.479

High

195811

KIN20
Casein kinase I isoform delta

1

4

Small-scale

0.479

High

195813

TDX1
Probable peroxiredoxin prdx-3

1

4

Small-scale

0.479

High

195821

Q95PZ7
Proteasome activator complex subunit 3

1

3

Small-scale

0.479

High

195822

SIR24
NAD-dependent protein deacetylase sir-2.4

1

13

Small-scale

0.479

High

195830

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.479

High

111862

HMG12
High mobility group protein hmg-12

1

0

Small-scale

0.458

High

195800

ADRM1
Proteasomal ubiquitin receptor ADRM1 homolog

1

0

Small-scale

0.458

High

112607

NH114
Nuclear hormone receptor 114

1

20

High-throughput

0.457

High

115506

H2KZI6
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

115625

H2KZU4
NR LBD domain-containing protein

1

20

High-throughput

0.457

High

195804

DX39B
Spliceosome RNA helicase DDX39B homolog

1

11

Small-scale

0.445

High

195829

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.438

High

195788

ACT4
Actin-4

1

1

Small-scale

0.437

High

195791

MTSS1
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.437

High

195795

TCPB
T-complex protein 1 subunit beta

1

1

Small-scale

0.437

High

195796

TCPD
T-complex protein 1 subunit delta

1

1

Small-scale

0.437

High

195824

Q9BL39
HMG box domain-containing protein

1

20

Small-scale

0.437

High

195825

TCPQ
T-complex protein 1 subunit theta

1

1

Small-scale

0.437

High

195831

Q9UAY9
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

Small-scale

0.437

High

195835

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

111829

CANB
Protein phosphatase 2B regulatory subunit cnb-1

1

0

Small-scale

0.249

Low

195641

O16689
OB domain-containing protein

1

0

Small-scale

0.249

Low

67322

A6ZJ46
SH3 domain-containing protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025