HitPredict

Interactor 1: SERA (O43175)
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)
Gene: PHGDH

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	32478681, 32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 533 Hs			1 465
+	Hs
		197433 SERA_HUMAN (1-533): 0: 667: 100.00		ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67
+	Hs
		197197 SERA_HUMAN (1-533): 0: 667: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		226998 CTBP2_HUMAN (21-383): 8.27e-123: 369: 29.10		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227360 CTBP1_HUMAN (21-384): 5.06e-120: 362: 29.89		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228959 GRHPR_HUMAN (6-316): 6.21e-117: 350: 28.66		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	At
		221722 SERA1_ARATH (6-523): 0: 545: 36.45		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Zm
		5037 A0A1D6DW07_MAIZE (2-513): 0: 532: 37.24		Q41754_MAIZE (1-76): 8.11e-30: 121: 31.58
+	Hs
		475539 CTBP2_HUMAN (21-383): 8.27e-123: 369: 29.10		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1092267 FDH_ARATH (7-315): 1.88e-103: 317: 29.25		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091986 HPR1_ARATH (6-340): 3.12e-93: 291: 28.69		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17