HitPredict

Interactor 1: ADA12 (O43184)
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha)
Gene: ADAM12

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25825872
Identification Methods	peptide array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 909 Hs			1 217
+	Mm
		1141131 ADA12_MOUSE (29-909): 0: 614: 80.82		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		197624 ADA12_HUMAN (1-909): 0: 665: 100.00		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		197579 ADA12_HUMAN (1-909): 0: 665: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		197581 ADA12_HUMAN (1-909): 0: 665: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		197601 ADA12_HUMAN (1-909): 0: 665: 100.00		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		197580 ADA12_HUMAN (1-909): 0: 665: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		197583 ADA12_HUMAN (1-909): 0: 665: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		557788 ADA19_HUMAN (5-907): 4.52e-167: 513: 41.68		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		433747 ADAM9_HUMAN (36-774): 2.04e-173: 525: 37.50		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		442882 ADA19_HUMAN (5-907): 4.52e-167: 513: 41.68		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433995 ADA19_HUMAN (5-907): 4.52e-167: 513: 41.68		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		523142 ADA19_HUMAN (5-907): 4.52e-167: 513: 41.68		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		411708 ADA15_HUMAN (35-874): 1.09e-131: 418: 34.52		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		442890 ADA22_HUMAN (3-863): 2.63e-147: 460: 26.40		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		434044 ADA22_HUMAN (3-863): 2.63e-147: 460: 26.40		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522899 ADAM8_HUMAN (29-855): 4.63e-145: 452: 33.88		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		337463 ADA15_HUMAN (35-874): 1.09e-131: 418: 34.52		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		412180 ADA15_HUMAN (35-874): 1.09e-131: 418: 34.52		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433344 ADA15_HUMAN (35-874): 1.09e-131: 418: 34.52		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		433748 ADA15_HUMAN (35-874): 1.09e-131: 418: 34.52		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47