Protein: PAX6
Paired box protein Pax-6 (Protein eyeless)

Gene: PAX6, ey
Organism: Drosophila melanogaster
Interactions: 73
UniProt ID: O18381

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001745 - compound eye morphogenesis
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

197555

ANTP
Homeotic protein antennapedia

2

20

Small-scale

0.768

High

197614

Q9W4B3
Visual system homeobox 2

1

20

High-throughput

0.637

High

197564

ABDA
Homeobox protein abdominal-A

1

20

High-throughput

0.621

High

197571

UBX
Homeotic protein ultrabithorax

1

20

High-throughput

0.621

High

197616

X2JDS9
Visual system homeobox 2

1

20

High-throughput

0.621

High

197595

DAN
Protein distal antenna

2

1

Small-scale

0.620

High

197550

PAX6
Paired box protein Pax-6

1

14

Small-scale

0.618

High

197553

HTH
Homeobox protein homothorax

1

9

Small-scale

0.618

High

197566

EXD
Homeobox protein extradenticle

1

7

Small-scale

0.618

High

197577

SO
Protein sine oculis

1

12

Small-scale

0.618

High

197560

DSX
Protein doublesex

2

7

High-throughput

0.594

High

197561

POXM
Paired box pox-meso protein

2

15

High-throughput

0.594

High

197562

POXN
Paired box pox-neuro protein

2

15

High-throughput

0.594

High

197593

Q961D1
Cyclin-K

2

2

High-throughput

0.594

High

197558

DA
Protein daughterless

1

0

Small-scale

0.586

High

197579

Q59DY9
Dachshund, isoform F

2

2

Small-scale

0.584

High

197563

DISC
Protein disconnected

2

0

High-throughput

0.569

High

197575

BRO
Protein brother

2

0

High-throughput

0.569

High

197596

DANR
Protein distal antenna-related

1

1

Small-scale

0.552

High

98514

F0JAR8
MIP29201p

2

1

High-throughput

0.542

High

197588

Q8T3W6
AT27166p

2

2

High-throughput

0.542

High

197598

Q9VF53
Aldehyde oxidase 1

2

2

High-throughput

0.542

High

197608

Q9W0B3
Vacuolar protein sorting-associated protein VTA1 homolog

2

1

High-throughput

0.542

High

197611

Q9W1V2
Tektin

2

4

High-throughput

0.542

High

56181

A1ZA01
Hormone receptor 51

1

20

High-throughput

0.541

High

197570

DSH
Segment polarity protein dishevelled

1

2

High-throughput

0.541

High

197576

HR78
Nuclear hormone receptor HR78

1

20

High-throughput

0.541

High

197599

Q9VFB9
GH09339p

1

2

High-throughput

0.541

High

197556

HP1
Heterochromatin protein 1

1

1

High-throughput

0.508

High

197604

Q9VQY7
Uncharacterized protein, isoform A

1

4

High-throughput

0.508

High

197610

Q9W0Q1
non-specific serine/threonine protein kinase

1

5

Small-scale

0.501

High

197565

HMPB
Homeotic protein proboscipedia

1

20

High-throughput

0.492

High

197567

CADF
Cofilin/actin-depolymerizing factor homolog

1

0

High-throughput

0.486

High

197590

INT9
Integrator complex subunit 9

1

0

High-throughput

0.486

High

197601

Q9VKC5
RH17958p

1

0

High-throughput

0.486

High

197559

GROU
Protein groucho

1

20

Small-scale

0.479

High

197572

EYA
Protein phosphatase eya

1

18

Small-scale

0.479

High

197591

FOXO
Forkhead box protein O

1

17

Small-scale

0.479

High

197597

Q9VEC5
Importin-13

1

7

High-throughput

0.479

High

197587

Q8IRZ1
Uncharacterized protein, isoform B

1

4

High-throughput

0.464

High

197592

MILT
Trafficking kinesin-binding protein milt

1

3

High-throughput

0.464

High

197552

CTBP
C-terminal-binding protein

1

0

Small-scale

0.458

High

197584

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.457

High

54830

A1Z904
Dystrobrevin

1

1

High-throughput

0.451

High

197578

Q29QK1
IP05464p

1

1

High-throughput

0.451

High

197585

Q8INY5
RE08003p1

1

1

High-throughput

0.451

High

197589

Q95RW2
Crk oncogene, isoform B

1

6

High-throughput

0.451

High

197613

Q9W481
LD15807p

1

1

High-throughput

0.451

High

197600

Q9VH81
protein-serine/threonine phosphatase

1

3

High-throughput

0.445

High

64507

NKAIN
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein

1

1

High-throughput

0.439

High

197554

O96692
small monomeric GTPase

1

6

High-throughput

0.439

High

197568

RALA
Ras-related protein Ral-a

1

5

High-throughput

0.439

High

197574

Q0E9B2
Dystrobrevin

1

1

High-throughput

0.439

High

197583

Q8I0K9
LD08455p

1

4

High-throughput

0.439

High

197586

Q8IRR4
GM27849p

1

1

High-throughput

0.439

High

197605

Q9VUE1
Histidine-rich glycoprotein

1

1

High-throughput

0.439

High

197615

CRK
Adapter molecule Crk

1

4

High-throughput

0.439

High

197617

X2JEH3
Uncharacterized protein, isoform E

1

1

High-throughput

0.439

High

197582

Q86BN4
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein

1

1

High-throughput

0.417

High

197594

Q962I2
small monomeric GTPase

1

5

High-throughput

0.417

High

197557

MS87F
Male-specific sperm protein Mst87F

2

0

High-throughput

0.310

High

197573

Q058Z8
GEO11848p1

2

0

High-throughput

0.310

High

197603

Q9VPZ1
GEO12410p1

2

0

High-throughput

0.310

High

197606

Q9VWW3
LD38082p

2

0

High-throughput

0.310

High

197607

Q9VYB9
LP02557p

2

0

High-throughput

0.310

High

197551

SURF4
Surfeit locus protein 4 homolog

1

0

High-throughput

0.265

Low

197569

RL9
Large ribosomal subunit protein uL6

1

0

High-throughput

0.265

Low

197580

Q7JZN2
Multiple C2 domain and transmembrane region protein, isoform B

1

0

High-throughput

0.265

Low

197609

Q9W0N2
IP07664p

1

0

High-throughput

0.265

Low

197612

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.265

Low

197581

Q7YU90
SD09829p

1

0

High-throughput

0.251

Low

197602

Q9VPE1
Uncharacterized protein, isoform C

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025