HitPredict

Interactor 1: IRAK2 (O43187)
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
Gene: IRAK2

Interactor 2: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.904

The method score is based on:

Property Details
Experiments 21903422, 12138165, 10383454, 16024789
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, in-gel kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death, Pkinase~Pkinase
Common GO terms GO:0001959 - regulation of cytokine-mediated signaling pathway
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 16 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 625
Hs

1 712
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024