Protein: GDIR1
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)

Gene: GDIR1, ARHGDIA
Organism: Homo sapiens
Interactions: 165
UniProt ID: P52565

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0005094 - Rho GDP-dissociation inhibitor activity
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

912546

RAC1
Ras-related C3 botulinum toxin substrate 1

16

20

Small-scale

0.985

High

912539

RHOA
Transforming protein RhoA

14

20

Small-scale

0.983

High

912536

CDC42
Cell division control protein 42 homolog

8

20

Small-scale

0.966

High

466166

RHOC
Rho-related GTP-binding protein RhoC

3

20

Small-scale

0.855

High

912548

RHOG
Rho-related GTP-binding protein RhoG

3

20

Small-scale

0.854

High

912535

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.806

High

912526

GDIR1
Rho GDP-dissociation inhibitor 1

3

0

Small-scale

0.791

High

912569

RHOH
Rho-related GTP-binding protein RhoH

2

20

Small-scale

0.775

High

580945

RAC2
Ras-related C3 botulinum toxin substrate 2

2

20

Small-scale

0.767

High

912543

RHOB
Rho-related GTP-binding protein RhoB

2

20

Small-scale

0.743

High

767404

RADI
Radixin

2

3

Small-scale

0.629

High

318676

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.618

High

375314

RASK
GTPase KRas

1

2

High-throughput

0.618

High

630734

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.618

High

912533

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.618

High

912542

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.618

High

912553

EWS
RNA-binding protein EWS

2

1

High-throughput

0.601

High

912561

CUL3
Cullin-3

2

0

Small-scale

0.585

High

840022

CASP3
Caspase-3

2

8

Small-scale

0.585

High

912530

CASP7
Caspase-7

2

8

Small-scale

0.585

High

241159

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

912549

XIAP
E3 ubiquitin-protein ligase XIAP

2

1

Small-scale

0.584

High

622555

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

3

Small-scale

0.575

High

674973

TNR6
Tumor necrosis factor receptor superfamily member 6

1

3

Small-scale

0.575

High

912559

FADD
FAS-associated death domain protein

1

2

Small-scale

0.575

High

582722

EZRI
Ezrin

2

3

Small-scale

0.571

High

912529

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.571

High

912585

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.571

High

912538

RL26
Large ribosomal subunit protein uL24

2

0

High-throughput

0.559

High

180756

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.536

High

213870

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

783540

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

912570

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

912604

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.536

High

458341

ADRB2
Beta-2 adrenergic receptor

1

0

Small-scale

0.529

High

912528

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.529

High

577673

PLAK
Junction plakoglobin

1

0

High-throughput

0.518

High

814492

FEN1
Flap endonuclease 1

1

0

High-throughput

0.518

High

857292

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.518

High

912595

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

High-throughput

0.518

High

909511

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

1

High-throughput

0.515

High

912562

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.515

High

912599

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

High-throughput

0.515

High

163263

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

3

Small-scale

0.514

High

385583

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

912554

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

853202

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.508

High

912540

UFM1
Ubiquitin-fold modifier 1

1

1

High-throughput

0.508

High

912573

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

912578

TWF2
Twinfilin-2

1

1

High-throughput

0.508

High

912580

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

1

High-throughput

0.508

High

912583

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

1

Small-scale

0.501

High

912590

KAT2B
Histone acetyltransferase KAT2B

1

2

Small-scale

0.501

High

912621

NEMO
NF-kappa-B essential modulator

1

1

Small-scale

0.501

High

912601

SH3G3
Endophilin-A3

1

2

High-throughput

0.494

High

912555

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.493

High

912614

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

High-throughput

0.493

High

912582

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.489

High

912598

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.489

High

168514

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

0

High-throughput

0.486

High

863195

3HAO
3-hydroxyanthranilate 3,4-dioxygenase

1

0

High-throughput

0.486

High

912567

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.486

High

912572

BAK
Bcl-2 homologous antagonist/killer

1

0

High-throughput

0.486

High

912597

C560
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

1

0

High-throughput

0.486

High

355176

ACL6A
Actin-like protein 6A

1

1

High-throughput

0.481

High

912547

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

912556

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.480

High

912616

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.480

High

259663

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

295475

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

Small-scale

0.479

High

395734

ESR1
Estrogen receptor

1

1

Small-scale

0.479

High

400519

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

479124

ENOG
Gamma-enolase

1

1

High-throughput

0.479

High

606473

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

685464

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

774941

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

828631

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.479

High

912534

MTPN
Myotrophin

1

2

High-throughput

0.479

High

912550

CYC
Cytochrome c

1

1

High-throughput

0.479

High

912551

VIGLN
Vigilin

1

1

High-throughput

0.479

High

912560

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

912575

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.479

High

912587

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

912588

HS105
Heat shock protein 105 kDa

1

3

High-throughput

0.479

High

912589

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

912603

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

912608

WDR26
WD repeat-containing protein 26

1

1

Small-scale

0.479

High

912610

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

912613

KCTD5
BTB/POZ domain-containing protein KCTD5

1

1

Small-scale

0.479

High

912619

EI2BD
Translation initiation factor eIF2B subunit delta

1

1

High-throughput

0.479

High

912620

SGT1
Protein SGT1 homolog

1

3

High-throughput

0.479

High

912527

ATX3
Ataxin-3

1

0

Small-scale

0.460

High

65524

DDTL
D-dopachrome decarboxylase-like protein

1

0

High-throughput

0.458

High

127305

LEG8
Galectin-8

1

0

Small-scale

0.458

High

136854

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

315314

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

371529

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

402757

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

411623

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

473869

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

588262

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

599179

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

642739

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

667672

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

690205

STOM
Stomatin

1

0

High-throughput

0.458

High

694988

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

715497

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

Small-scale

0.458

High

772114

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

830390

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

849308

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

872100

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

912537

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

912541

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

912544

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

912545

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

912552

SET
Protein SET

1

0

Small-scale

0.458

High

912558

PAK1
Serine/threonine-protein kinase PAK 1

1

0

Small-scale

0.458

High

912564

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

912566

CUL7
Cullin-7

1

0

High-throughput

0.458

High

912568

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

912571

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

912579

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

912581

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

912592

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

912600

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

912605

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

912609

MYO10
Unconventional myosin-X

1

0

Small-scale

0.458

High

912611

TNR19
Tumor necrosis factor receptor superfamily member 19

1

0

Small-scale

0.458

High

912615

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

912617

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

912596

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.457

High

429563

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

683807

MOES
Moesin

1

3

Small-scale

0.445

High

712841

CASP1
Caspase-1

1

8

Small-scale

0.445

High

853632

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.445

High

912532

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

912565

CASP8
Caspase-8

1

8

Small-scale

0.445

High

912591

CASPA
Caspase-10

1

8

Small-scale

0.445

High

444937

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

912584

AN13A
Ankyrin repeat domain-containing protein 13A

1

3

High-throughput

0.437

High

912593

RN125
E3 ubiquitin-protein ligase RNF125

1

2

Small-scale

0.437

High

912606

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

912618

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.437

High

518737

GRAB
Granzyme B

1

0

Small-scale

0.426

High

529391

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

869468

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

Small-scale

0.426

High

912531

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.426

High

912557

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.426

High

912594

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

912576

Q6FI97
Actin-like protein 6A

1

1

High-throughput

0.417

High

912586

KCNRG
Potassium channel regulatory protein

1

3

High-throughput

0.417

High

886658

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

912602

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.299

High

912612

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

258257

TRI13
E3 ubiquitin-protein ligase TRIM13

1

0

High-throughput

0.251

Low

105617

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

276087

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

276763

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.249

Low

353128

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

767755

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

912563

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

912574

PRC2B
Protein PRRC2B

1

0

High-throughput

0.249

Low

912607

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

912577

Q6IBE6
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025