HitPredict

Interactor 1: SIAH2 (O43255)
E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)
Gene: SIAH2

Interactor 2: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	23695783
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 324 Hs			1 145
+	Dm
		598891 SINA_DROME (64-321): 2.01e-107: 317: 79.46		Q9VRL1_DROME (3-143): 4.05e-72: 214: 66.67
+	Hs
		199099 SIAH2_HUMAN (1-324): 8.84e-116: 339: 100.00		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		199105 SIAH2_HUMAN (1-324): 8.84e-116: 339: 100.00		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		199103 SIAH2_HUMAN (1-324): 8.84e-116: 339: 100.00		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		199106 SIAH2_HUMAN (1-324): 8.84e-116: 339: 100.00		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01
+	Hs
		1216737 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UB2D4_HUMAN (10-144): 9.98e-60: 183: 24.27
+	Hs
		849364 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		919778 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UB2D2_HUMAN (10-144): 3.07e-58: 179: 22.06
+	Hs
		1079002 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UB2V2_HUMAN (1-145): 4.36e-58: 178: 100.00
+	Hs
		1216680 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UB2E3_HUMAN (2-143): 6.26e-57: 178: 23.08
+	Hs
		895842 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UB2D3_HUMAN (10-144): 9.91e-58: 178: 22.06
+	Hs
		1216686 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UB2E2_HUMAN (2-143): 7.87e-57: 177: 23.08
+	Dm
		598811 SINA_DROME (64-321): 2.01e-107: 317: 79.46		UBCD1_DROME (10-144): 5.08e-58: 178: 23.53
+	Dm
		598846 SINA_DROME (64-321): 2.01e-107: 317: 79.46		Q8IQ53_DROME (41-143): 1.58e-57: 175: 61.17
+	Hs
		930288 SIAH1_HUMAN (28-322): 6.56e-109: 320: 75.25		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01
+	Dm
		639400 SINAL_DROME (4-319): 3.54e-99: 297: 42.46		UBCD1_DROME (10-144): 5.08e-58: 178: 23.53
+	At
		1323941 SINL7_ARATH (38-278): 4.47e-52: 175: 21.22		UEV1D_ARATH (2-143): 1.32e-74: 220: 49.30
+	Dm
		854568 SINAL_DROME (4-319): 3.54e-99: 297: 42.46		UBCD2_DROME (30-122): 4.73e-12: 63: 30.85
+	Hs
		849360 TRI50_HUMAN (72-275): 1.69e-43: 157: 20.08		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		851837 TRI50_HUMAN (72-275): 1.69e-43: 157: 20.08		UB2E1_HUMAN (1-143): 2.16e-56: 176: 22.92