HitPredict

Interactor 1: SPIT1 (O43278)
Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)
Gene: SPINT1

Interactor 2: HGFA (Q04756)
Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]
Gene: HGFAC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.73 1.00 0.857

The method score is based on:

Property Details
Experiments 33961781, 20004165, 15713485
Identification Methods affinity chromatography technology, enzyme linked immunosorbent assay, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Kunitz_BPTI~Trypsin, Ldl_recept_a~Trypsin
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 529
Hs

1 655
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Last updated: 15 Jul 2024