HitPredict

Interactor 1: EFS (O43281)
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
Gene: EFS

Interactor 2: OSTF1 (Q92882)
Osteoclast-stimulating factor 1
Gene: OSTF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_9
Common GO terms	GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 561 Hs			1 214
+	Hs
		199510 EFS_HUMAN (1-561): 3.37e-71: 239: 100.00		GRB2_HUMAN (11-66): 5.89e-12: 64.3: 48.21
+	Mm
		222869 ACK1_MOUSE (11-484): 7.98e-29: 124: 15.31		ANK2_MOUSE (7-213): 6.1e-37: 138: 11.84
+	Mm
		103609 MICA3_MOUSE (30-424): 1.1e-22: 105: 11.48		ANK3_MOUSE (34-213): 9.14e-34: 129: 17.62
+	Hs
		1021422 MICA3_HUMAN (61-424): 2.25e-21: 100: 16.45		ANK3_HUMAN (7-213): 1.88e-34: 131: 14.46
+	Hs
		978563 PRB3_HUMAN (193-431): 5.74e-14: 75.5: 14.82		ANKK1_HUMAN (4-192): 9.37e-35: 131: 20.00
+	Hs
		1054786 CASL_HUMAN (6-336): 2.64e-31: 131: 24.93		ANS1A_HUMAN (3-113): 1.78e-11: 64.6: 19.82
+	Hs
		1186086 MICA3_HUMAN (61-424): 2.25e-21: 100: 16.45		BARD1_HUMAN (136-213): 9.08e-17: 80: 20.51
+	Hs
		924703 MINK1_HUMAN (48-378): 5.94e-26: 115: 14.67		GRB2_HUMAN (11-66): 5.89e-12: 64.3: 48.21
+	Hs
		1256280 SH3R3_HUMAN (12-390): 3.66e-21: 99.8: 15.01		TANC2_HUMAN (122-213): 8.25e-16: 77.3: 17.90
+	Hs
		924513 ACK1_HUMAN (9-484): 1.17e-23: 107: 14.85		GRB2_HUMAN (11-66): 5.89e-12: 64.3: 48.21
+	Hs
		1268507 CASS4_HUMAN (379-557): 1.65e-20: 97.9: 19.89		ANS1A_HUMAN (3-113): 1.78e-11: 64.6: 19.82
+	Hs
		1191811 CASS4_HUMAN (379-557): 1.65e-20: 97.9: 19.89		ANS1B_HUMAN (1-129): 5.53e-11: 63.4: 15.27
+	Hs
		203218 SYNJ1_HUMAN (95-472): 7.88e-19: 92.8: 13.96		GRB2_HUMAN (11-66): 5.89e-12: 64.3: 48.21
+	Hs
		203249 SYNJ1_HUMAN (95-472): 7.88e-19: 92.8: 13.96		SH3G2_HUMAN (4-66): 6.52e-10: 59.7: 47.62
+	Rn
		192354 SYNJ1_RAT (95-481): 1.04e-18: 92.5: 11.30		SH3G2_RAT (4-66): 5.5e-10: 59.7: 47.62
+	Rn
		192356 SYNJ1_RAT (95-481): 1.04e-18: 92.5: 11.30		SH3G3_RAT (11-66): 1.45e-09: 58.5: 46.43
+	Mm
		88459 D3Z656_MOUSE (95-466): 1.51e-17: 89: 12.83		SH3G2_MOUSE (4-66): 6.16e-10: 59.7: 47.62
+	Mm
		88460 D3Z656_MOUSE (95-466): 1.51e-17: 89: 12.83		SH3G3_MOUSE (2-66): 5.97e-10: 59.7: 43.08
+	Hs
		554292 MUC1_HUMAN (63-481): 6.08e-16: 83.6: 11.37		GRB2_HUMAN (11-66): 5.89e-12: 64.3: 48.21
+	Hs
		882224 BCAR1_HUMAN (7-431): 2.78e-12: 71.7: 21.40		GRB2_HUMAN (11-66): 5.89e-12: 64.3: 48.21