HitPredict

Interactor 1: SRGP3 (O43295)
SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)
Gene: SRGAP3

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1099 Hs			1 1128
+	Hs
		200226 SRGP3_HUMAN (1-1099): 0: 799: 100.00		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Hs
		985567 HMHA1_HUMAN (30-834): 1.36e-89: 314: 13.33		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		1268317 HMHA1_HUMAN (30-834): 1.36e-89: 314: 13.33		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Hs
		551050 CHIN_HUMAN (240-694): 2.07e-91: 302: 18.59		ANKK1_HUMAN (994-1128): 1.12e-27: 122: 15.22
+	Hs
		856146 CHIO_HUMAN (241-694): 6.07e-81: 274: 17.06		ANKK1_HUMAN (994-1128): 1.12e-27: 122: 15.22
+	Hs
		506657 BCR_HUMAN (503-664): 2.94e-17: 89.7: 29.63		TNKS2_HUMAN (893-1127): 6.78e-43: 172: 14.54
+	Hs
		161400 RHG24_HUMAN (520-701): 3.97e-23: 108: 32.09		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89