HitPredict

Interactor 1: ARHG9 (O43307)
Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9)
Gene: ARHGEF9

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 516 Hs			1 191
+	Hs
		925527 SPT13_HUMAN (1-516): 1.73e-138: 416: 60.27		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894323 SPT13_HUMAN (1-516): 1.73e-138: 416: 60.27		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		925649 ARHG4_HUMAN (1-516): 2.43e-134: 406: 58.14		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894480 ARHG4_HUMAN (1-516): 2.43e-134: 406: 58.14		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		900947 ARHG4_HUMAN (1-516): 2.43e-134: 406: 58.14		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		564524 ARHG7_HUMAN (5-513): 6.16e-96: 309: 20.20		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		1049733 ARHG7_HUMAN (5-513): 6.16e-96: 309: 20.20		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		925271 ARHG7_HUMAN (5-513): 6.16e-96: 309: 20.20		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		893997 ARHG7_HUMAN (5-513): 6.16e-96: 309: 20.20		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		545368 ARHG7_HUMAN (5-513): 6.16e-96: 309: 20.20		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		894047 ITSN1_HUMAN (10-476): 4.3e-90: 304: 18.50		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		892365 ARHG7_HUMAN (5-513): 6.16e-96: 309: 20.20		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Gg
		1141019 ARHG6_CHICK (6-516): 9.55e-89: 290: 18.36		Q6LC82_CHICK (1-191): 1.75e-84: 249: 70.31
+	Hs
		925455 PREX1_HUMAN (58-467): 2.64e-85: 290: 29.61		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		894238 PREX1_HUMAN (58-467): 2.64e-85: 290: 29.61		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		1049714 ARHG7_HUMAN (5-513): 6.16e-96: 309: 20.20		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Hs
		900718 PREX1_HUMAN (58-467): 2.64e-85: 290: 29.61		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		855778 VAV2_HUMAN (69-432): 1.83e-86: 286: 22.83		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		855779 VAV2_HUMAN (69-432): 1.83e-86: 286: 22.83		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		1078851 ITSN1_HUMAN (10-476): 4.3e-90: 304: 18.50		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82