HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: TRAF4 (Q9BUZ4)
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
Gene: TRAF4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23973329
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 606 Hs			1 470
+	Hs
		201318 M3K7_HUMAN (1-606): 0: 574: 100.00		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Mm
		761816 M3K7_MOUSE (1-606): 0: 545: 94.88		TRAF2_MOUSE (2-465): 1.21e-117: 355: 30.06
+	Hs
		129515 M3K7_HUMAN (1-606): 0: 574: 100.00		TRAF5_HUMAN (2-465): 7.74e-104: 322: 24.95
+	Hs
		201322 M3K7_HUMAN (1-606): 0: 574: 100.00		TRAF3_HUMAN (3-465): 2.47e-92: 292: 22.99
+	Rn
		78178 M3K7_RAT (1-606): 0: 573: 99.01		TRAF6_RAT (3-464): 3.89e-86: 275: 25.43
+	Hs
		201483 M3K7_HUMAN (1-606): 0: 574: 100.00		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Mm
		936234 M3K7_MOUSE (1-606): 0: 545: 94.88		TRAF6_MOUSE (3-464): 9.4e-87: 277: 25.00
+	Hs
		983596 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		1052836 FAK2_HUMAN (31-603): 1.5e-116: 372: 18.58		TRAF4_HUMAN (1-470): 5.03e-120: 361: 100.00
+	Dm
		1359091 M3K7_DROME (31-593): 6.48e-121: 374: 33.06		Q9XYR0_DROME (66-470): 1.14e-116: 353: 44.44
+	Hs
		872432 EPHA5_HUMAN (16-325): 4.76e-100: 328: 28.27		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		1021002 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Dm
		1359089 M3K7_DROME (31-593): 6.48e-121: 374: 33.06		Q9W3I9_DROME (2-464): 1.97e-72: 238: 19.49
+	Hs
		1377873 RIPK3_HUMAN (31-498): 1.9e-103: 324: 25.29		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Mm
		761825 M3K11_MOUSE (29-287): 6.85e-37: 149: 35.27		TRAF2_MOUSE (2-465): 1.21e-117: 355: 30.06
+	Zm
		74360 B4FVR0_MAIZE (22-302): 8.99e-102: 316: 33.45		B4FCG7_MAIZE (9-170): 1.88e-40: 150: 22.29
+	Hs
		1157054 M3K20_HUMAN (27-287): 2.26e-39: 156: 36.16		ZN544_HUMAN (32-352): 7.56e-53: 191: 9.55
+	Hs
		1343994 M3K20_HUMAN (27-287): 2.26e-39: 156: 36.16		ZNF71_HUMAN (4-216): 4.29e-41: 154: 13.95
+	Hs
		1169144 M3K20_HUMAN (27-287): 2.26e-39: 156: 36.16		ZFP2_HUMAN (4-161): 4.06e-21: 97.6: 12.03
+	Hs
		1230633 M3K20_HUMAN (27-287): 2.26e-39: 156: 36.16		ZN567_HUMAN (205-361): 1.14e-13: 75.2: 10.47