HitPredict - High confidence protein-protein interactions

Interactor 1: RIPK2 (O43353)
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
Gene: RIPK2

Interactor 2: NOD2 (Q9HC29)
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
Gene: NOD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.986

Property	Details
Experiments	27812135, 15620648, 21123652, 26670046, 27545878, 11087742, 19592251, 22607974, 21097508, 16714539, 16552041, 16492792, 17054981, 19266573, 19464198, 19337385, 19667203, 24790089, 21931826, 22829933
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, two hybrid, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CARD~CARD
Common GO terms	GO:0002250 - adaptive immune response GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton and 29 others more... GO:0005886 - plasma membrane GO:0007254 - JNK cascade GO:0031982 - vesicle GO:0032731 - positive regulation of interleukin-1 beta production GO:0032735 - positive regulation of interleukin-12 production GO:0032755 - positive regulation of interleukin-6 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0032874 - positive regulation of stress-activated MAPK cascade GO:0032991 - protein-containing complex GO:0034134 - toll-like receptor 2 signaling pathway GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043330 - response to exogenous dsRNA GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046330 - positive regulation of JNK cascade GO:0050700 - CARD domain binding GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0051403 - stress-activated MAPK cascade GO:0060907 - positive regulation of macrophage cytokine production GO:0070371 - ERK1 and ERK2 cascade GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0070431 - nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0071224 - cellular response to peptidoglycan GO:0071225 - cellular response to muramyl dipeptide GO:0098792 - xenophagy GO:1902523 - positive regulation of protein K63-linked ubiquitination GO:1904417 - positive regulation of xenophagy
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	540
Hs

1	1040

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Last updated: 15 Jul 2024