Interactor 1: IF4G3 (O43432)
Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)
Gene: EIF4G3

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 9418880, 37071682, 28514442, 17353931, 29395067, 33961781, 35271311
Identification Methods affinity chromatography technology, cross-linking study, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~MA3, Helicase_C~MA3, DEAD~MIF4G, Helicase_C~MIF4G
Common GO terms GO:0000339 - RNA cap binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
and 3 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1585
Hs

1 406
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Dm
+ Dm
+ At
+ Sc
+ Hs
+ Sc
+ Hs
+ Mm
+ Hs
+ Sc
+ Sc
+ Hs
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024