Protein: SETX
Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin)

Gene: SETX
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q7Z333

Gene Ontology (top 5):
GO:0000228 - nuclear chromosome
GO:0000781 - chromosome, telomeric region
GO:0001147 - transcription termination site sequence-specific DNA binding
GO:0003677 - DNA binding
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1275926

SETX
Probable helicase senataxin

1

6

Small-scale

0.740

High

799239

BRCA1
Breast cancer type 1 susceptibility protein

4

6

Small-scale

0.701

High

1061249

RHG01
Rho GTPase-activating protein 1

2

1

High-throughput

0.628

High

1096455

PAK1
Serine/threonine-protein kinase PAK 1

2

2

High-throughput

0.628

High

1275984

FZD10
Frizzled-10

2

1

High-throughput

0.628

High

993632

UBC9
SUMO-conjugating enzyme UBC9

2

1

Small-scale

0.620

High

154843

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

1

High-throughput

0.609

High

127122

APBB1
Amyloid beta precursor protein binding family B member 1

2

0

High-throughput

0.602

High

139401

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.602

High

1199860

SETMR
Histone-lysine N-methyltransferase SETMAR

2

0

High-throughput

0.602

High

1275982

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.602

High

1275986

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

0

High-throughput

0.602

High

1275989

NGN3
Neurogenin-3

2

0

High-throughput

0.602

High

1275990

CD2AP
CD2-associated protein

2

0

High-throughput

0.602

High

991355

SUMO1
Small ubiquitin-related modifier 1

2

2

Small-scale

0.595

High

1275938

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

714223

PML
Protein PML

2

10

High-throughput

0.584

High

388232

GLPA
Glycophorin-A

2

0

High-throughput

0.576

High

835309

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

1

High-throughput

0.574

High

372411

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.571

High

396408

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

1275968

CAD19
Cadherin-19

2

1

High-throughput

0.558

High

667355

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.554

High

1101554

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

1

High-throughput

0.549

High

74526

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

16

High-throughput

0.536

High

130525

SPT5H
Transcription elongation factor SPT5

1

3

High-throughput

0.536

High

239106

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.536

High

295597

CIB2
Calcium and integrin-binding family member 2

1

2

High-throughput

0.536

High

317342

ACL6B
Actin-like protein 6B

1

2

High-throughput

0.536

High

332161

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.536

High

457521

TBB5
Tubulin beta chain

1

2

High-throughput

0.536

High

665267

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.536

High

945938

LOXL3
Lysyl oxidase homolog 3

1

1

High-throughput

0.536

High

958980

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.536

High

976109

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

3

High-throughput

0.536

High

997399

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.536

High

1065262

SSRP1
FACT complex subunit SSRP1

1

7

High-throughput

0.536

High

1097212

PAK2
Serine/threonine-protein kinase PAK 2

1

2

High-throughput

0.536

High

1144043

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1216373

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

1275937

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.536

High

1275947

TRI52
E3 ubiquitin-protein ligase TRIM52

1

4

High-throughput

0.536

High

1275948

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1275957

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1275960

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.536

High

1275962

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

1

6

High-throughput

0.536

High

1275971

SENP3
Sentrin-specific protease 3

1

3

High-throughput

0.536

High

1275983

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.536

High

1275992

NPTN
Neuroplastin

1

1

High-throughput

0.536

High

248220

NDK8
Putative nucleoside diphosphate kinase

2

0

High-throughput

0.528

High

656169

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.515

High

288445

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

High-throughput

0.515

High

1275967

SKI8
Superkiller complex protein 8

1

5

High-throughput

0.515

High

158459

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

317729

NOL4
Nucleolar protein 4

1

0

High-throughput

0.513

High

390083

ALBU
Albumin

1

0

High-throughput

0.513

High

486581

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

503616

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

533704

CLUS
Clusterin

1

0

High-throughput

0.513

High

593416

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

1022893

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

1034688

MEF2A
Myocyte-specific enhancer factor 2A

1

0

High-throughput

0.513

High

1099715

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1160500

SMN
Survival motor neuron protein

1

0

Small-scale

0.513

High

1163927

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

1238945

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.513

High

1275954

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1275955

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.513

High

1275961

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.513

High

1275963

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

1275965

IFT27
Intraflagellar transport protein 27 homolog

1

0

High-throughput

0.513

High

1275966

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1275973

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

High-throughput

0.513

High

1275976

ANR10
Ankyrin repeat domain-containing protein 10

1

0

High-throughput

0.513

High

1275991

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

297642

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.508

High

508198

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

Small-scale

0.508

High

1054476

EXOS9
Exosome complex component RRP45

1

1

Small-scale

0.508

High

1088417

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

3

Small-scale

0.508

High

1275970

HIPK2
Homeodomain-interacting protein kinase 2

1

6

Small-scale

0.508

High

1275975

TOPRS
E3 ubiquitin-protein ligase Topors

1

2

Small-scale

0.508

High

951728

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.501

High

162613

ANM5
Protein arginine N-methyltransferase 5

1

3

Small-scale

0.500

High

210402

MTLR
Motilin receptor

1

1

High-throughput

0.489

High

867980

GLR
Glucagon receptor

1

2

High-throughput

0.489

High

1177011

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

1275932

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

1

High-throughput

0.489

High

1275936

CNTRB
Centrobin

1

1

High-throughput

0.489

High

1275956

CIB3
Calcium and integrin-binding family member 3

1

2

High-throughput

0.489

High

1110901

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.486

High

1275979

SAE2
SUMO-activating enzyme subunit 2

1

0

Small-scale

0.486

High

964347

SUMO2
Small ubiquitin-related modifier 2

1

2

Small-scale

0.481

High

132130

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

138193

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.479

High

157548

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

242118

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

331088

KI20A
Kinesin-like protein KIF20A

1

13

High-throughput

0.479

High

363492

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

401048

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

414099

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

821133

TXLNA
Alpha-taxilin

1

4

High-throughput

0.479

High

886989

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.479

High

897882

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

904877

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

907483

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

Small-scale

0.479

High

979893

H4
Histone H4

1

4

High-throughput

0.479

High

998480

H31
Histone H3.1

1

2

High-throughput

0.479

High

1026444

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1049486

1433F
14-3-3 protein eta

1

4

High-throughput

0.479

High

1107863

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1137367

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1140479

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1155498

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

High-throughput

0.479

High

1220597

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1235641

NIPBL
Nipped-B-like protein

1

2

High-throughput

0.479

High

1250006

WDR82
WD repeat-containing protein 82

1

10

High-throughput

0.479

High

1275927

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1275929

SLN11
Schlafen family member 11

1

3

High-throughput

0.479

High

1275933

SKAP1
Src kinase-associated phosphoprotein 1

1

8

High-throughput

0.479

High

1275935

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1275942

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1275944

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.479

High

1275946

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1275949

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

9

High-throughput

0.479

High

1275950

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.479

High

1275951

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1275964

LST8
Target of rapamycin complex subunit LST8

1

4

High-throughput

0.479

High

1275974

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1275981

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

958787

ARF3
ADP-ribosylation factor 3

1

0

High-throughput

0.458

High

1088890

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1275972

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1275977

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1275980

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

1275987

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.458

High

1275993

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

171494

S27A2
Long-chain fatty acid transport protein 2

1

4

High-throughput

0.445

High

290613

SURF6
Surfeit locus protein 6

1

3

High-throughput

0.445

High

344231

PTBP3
Polypyrimidine tract-binding protein 3

1

9

High-throughput

0.445

High

686234

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.445

High

729328

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

12

Small-scale

0.445

High

886086

CXCR3
C-X-C chemokine receptor type 3

1

1

High-throughput

0.445

High

1034589

AK17A
A-kinase anchor protein 17A

1

3

High-throughput

0.445

High

1111064

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.445

High

1185855

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

1

High-throughput

0.445

High

1275985

ABT1
Activator of basal transcription 1

1

3

High-throughput

0.445

High

1141727

EEA1
Early endosome antigen 1

1

3

High-throughput

0.437

High

166333

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

208296

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

640203

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.426

High

1275958

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.426

High

50603

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.407

High

390908

TRFE
Serotransferrin

1

1

High-throughput

0.407

High

704032

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

732931

GASR
Gastrin/cholecystokinin type B receptor

1

1

High-throughput

0.407

High

1240882

S27A4
Long-chain fatty acid transport protein 4

1

4

High-throughput

0.407

High

1243617

S27A1
Long-chain fatty acid transport protein 1

1

4

High-throughput

0.407

High

1275930

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

1

High-throughput

0.407

High

1275953

Q96KY9
CDH19 protein

1

1

High-throughput

0.407

High

1275978

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

7

High-throughput

0.407

High

1275988

S27A6
Long-chain fatty acid transport protein 6

1

4

High-throughput

0.407

High

1275931

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

1275941

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

71221

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

253859

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

316519

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.279

Low

387284

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.279

Low

640409

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

0

High-throughput

0.279

Low

656008

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

1219977

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1249797

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1275943

CC4L
C-C motif chemokine 4-like

1

0

High-throughput

0.279

Low

1275945

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low

1275952

FAH2A
Oxaloacetate tautomerase FAHD2A, mitochondrial

1

0

High-throughput

0.279

Low

1275959

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.279

Low

1275969

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

0

High-throughput

0.279

Low

1275939

SAMD3
Sterile alpha motif domain-containing protein 3

1

0

High-throughput

0.268

Low

1248890

LCN15
Lipocalin-15

1

0

High-throughput

0.249

Low

1275940

CN178
Putative uncharacterized protein SLIRP-OT1

1

0

Small-scale

0.249

Low

652649

GNLY
Granulysin

1

0

High-throughput

0.232

Low

1275928

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

1275934

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025