HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: BIRC7 (Q96CA5)
Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]
Gene: BIRC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	26186194, 28514442, 33961781, 11801603
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 298
+	Mm
		57638 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC7_MOUSE (1-298): 4.51e-81: 248: 63.42
+	Hs
		204062 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC6_HUMAN (54-252): 6.52e-36: 138: 21.10
+	Mm
		140034 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC3_MOUSE (84-161): 1.59e-20: 93.5: 38.46
+	Mm
		1143669 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC2_MOUSE (238-298): 8.36e-20: 91.2: 72.58
+	Hs
		204007 HTRA2_HUMAN (1-458): 0: 528: 100.00		MYLIP_HUMAN (152-297): 3.79e-26: 108: 22.45
+	Hs
		203927 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC3_HUMAN (240-298): 5.43e-20: 92: 71.67
+	Mm
		1141992 HTRA2_MOUSE (1-458): 0: 549: 84.93		XIAP_MOUSE (1-96): 2.2e-12: 68.9: 18.18
+	Hs
		203928 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Hs
		204028 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC8_HUMAN (1-96): 5.33e-17: 80.4: 18.18
+	Hs
		203914 HTRA2_HUMAN (1-458): 0: 528: 100.00		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Hs
		949083 HTRA3_HUMAN (28-456): 3.06e-163: 469: 42.86		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Hs
		957747 HTRA1_HUMAN (26-455): 3.16e-146: 427: 41.05		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Dm
		1097061 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP1_DROME (77-253): 8.76e-22: 96.6: 20.23
+	Hs
		949005 HTRA4_HUMAN (28-455): 1.19e-125: 375: 38.67		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Dm
		1097138 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP2_DROME (84-207): 3.25e-11: 65.4: 24.43