HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: BIRC8 (Q96P09)
Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis)
Gene: BIRC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 236
+	Mm
		57638 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC7_MOUSE (1-236): 5.48e-55: 179: 30.25
+	Hs
		204017 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC7_HUMAN (1-236): 4.79e-61: 195: 33.47
+	Hs
		204062 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC6_HUMAN (1-185): 2.65e-36: 137: 20.31
+	Mm
		140034 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC3_MOUSE (4-95): 2.14e-17: 82.7: 32.98
+	Mm
		1143669 HTRA2_MOUSE (1-458): 0: 549: 84.93		BIRC2_MOUSE (4-102): 3.96e-16: 78.9: 29.70
+	Mm
		1141992 HTRA2_MOUSE (1-458): 0: 549: 84.93		XIAP_MOUSE (3-211): 9.45e-14: 71.9: 16.90
+	Hs
		204007 HTRA2_HUMAN (1-458): 0: 528: 100.00		MYLIP_HUMAN (166-235): 7.52e-21: 92.2: 35.71
+	Hs
		203927 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC3_HUMAN (4-158): 5.42e-18: 84.3: 24.20
+	Hs
		203928 HTRA2_HUMAN (1-458): 0: 528: 100.00		BIRC2_HUMAN (4-148): 2.85e-16: 79.3: 24.49
+	Hs
		203914 HTRA2_HUMAN (1-458): 0: 528: 100.00		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		949083 HTRA3_HUMAN (28-456): 3.06e-163: 469: 42.86		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		957747 HTRA1_HUMAN (26-455): 3.16e-146: 427: 41.05		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		949005 HTRA4_HUMAN (28-455): 1.19e-125: 375: 38.67		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Dm
		1097061 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP1_DROME (4-84): 6.4e-19: 86.6: 32.93
+	Dm
		1097138 HTRA2_DROME (141-455): 5.68e-118: 353: 50.15		DIAP2_DROME (1-107): 1.18e-10: 62.7: 20.18